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Human-relevant urothelial model provides insight into infection strategies and host response
Use of a 3D urine-tolerant human urothelial model (3D-UHU), which recapitulates the crucial features of human urothelium, ...
Management and cost of stent encrustation in pregnancy
Ureteral stents are useful devices for urological management in pregnancy. However, stent encrustation occurs in up to 13%...
Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System
Diagnostic work-up and risk stratification in patients with bladder cancer before and after treatment must be refined to o...
Genetic and biological drivers of prostate cancer disparities in Black men
Genetic and biological drivers of prostate cancer disparities in Black men
Black men with prostate cancer have historically had worse outcomes than white men with prostate cancer. The causes of thi...
Generative AI in scientific publishing: disruptive or destructive?
Artificial intelligence (AI) has the potential to revolutionize scientific publishing. The influence of AI could be disrup...
Idea sprint: generating research priorities for urinary stone disease
The escalating global prevalence of urinary stone disease and its impact on public health reflects the need to synthesize ...
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
The stromal component of the tumour microenvironment in primary and metastatic prostate cancer can influence and promote d...
Bladder-sparing neoadjuvant therapy for MIBC
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Resolving the puzzle of same-sex sexual interactions
Sexual interactions between members of the same sex are common but the reasons for these behaviours are not always clear. ...
Hallmark discoveries in the biology of Wilms tumour
Hallmark discoveries in the biology of Wilms tumour
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ ...
Frequency, morbidity and equity — the case for increased research on male fertility
Frequency, morbidity and equity — the case for increased research on male fertility
Currently, most men with infertility cannot be given an aetiology, which reflects a lack of knowledge around gamete produc...
Family dynamics: fathers’ smoking affects children’s epigenetics
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Kidney xenotransplantation
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Unlocking the mystery of the human Y chromosome
Much of the Y chromosome has remained obscure owing to the challenge of sequencing repetitive genomic regions. Recently, t...
Diagnostic liquid biopsy biomarkers in renal cell cancer
Diagnostic liquid biopsy biomarkers in renal cell cancer
The clinical presentation of renal cell cancer (RCC) is shifting towards incidental and early detection, creating new chal...
Improved phenotypic classification of male infertility to promote discovery of genetic causes
Improved phenotypic classification of male infertility to promote discovery of genetic causes
An increasing number of genes are being described in the context of non-syndromic male infertility. Linking the underlying...
Feasibility and potential of an MRI-based prostate cancer screening
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Accessing information in the AI age
Online sources are increasingly being used by patients to obtain medical information. The newest of these resources, artif...
Proteomic-based analysis of testicular interstitial fluid
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A fully transperineal approach for prostate biospy
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A clinical guide to rare male sexual disorders
A clinical guide to rare male sexual disorders
Conditions referred to as ‘male sexual dysfunctions’ usually include erectile dysfunction, ejaculatory disorde...
PSMA-targeted fluorescence guidance for robotic-assisted prostatectomy
PSMA-targeted fluorescence guidance for robotic-assisted prostatectomy
Positive surgical margins are an independent risk factor for biochemical recurrence after radical prostatectomy. However, ...
Turning up the heat: CTLA4 blockade in urothelial cancer
Turning up the heat: CTLA4 blockade in urothelial cancer
Anti-PD1 and anti-PDL1 monotherapies have shown clinical efficacy in stage IV urothelial cancer and are integrated into cu...
Bioinformatics in urology — molecular characterization of pathophysiology and response to treatment
Bioinformatics in urology — molecular characterization of pathophysiology and response to treatment
The application of bioinformatics has revolutionized the practice of medicine in the past 20 years. From early studies tha...
The sex gap in bladder cancer survival — a missing link in bladder cancer care?
The sex gap in bladder cancer survival — a missing link in bladder cancer care?
The differences in bladder cancer outcomes between the sexes has again been highlighted. Uncommon among cancers, bladder c...
Bladder cancer oligometastases — definition and treatment
Oligometastatic bladder cancer, defined as a cancer with limited metastases, is a potential target for curative metastasis...
New insights into APOBEC-mediated mutagenesis in prostate cancer
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Nicardipine inhibits chemoresistance in prostate cancer
In a new study published in the British Journal of Cancer, a phenotypic screening was carried out in two prostate cancer c...
Tuft cells in prostate cancer
Tuft cells are chemosensory cells that increase in number following an injury or disease — including tumours — and activat...
Platin-L improves cisplatin resistance
Resistance to cisplatin, one of the most widely used chemotherapeutics, is often reported in prostate cancer. In a study p...
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