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Efficacy and safety of SGLT2 inhibitors in nondiabetic patients with CKD: a review of recent evidence
Efficacy and safety of SGLT2 inhibitors in nondiabetic patients with CKD: a review of recent evidence
Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) were initially developed as glucose-lowering agents in pati...
Strategies to improve long-term outcomes for patients with chronic kidney disease in China
Strategies to improve long-term outcomes for patients with chronic kidney disease in China
Background: Chronic kidney disease (CKD) is an incurable disease requiring lifelong management. China has a high prevalenc...
Kidney Involvement in Autoinflammatory Diseases
Kidney Involvement in Autoinflammatory Diseases
<b><i>Background:</i></b> Autoinflammatory diseases (AIDs) were first proposed 20 years ago and ca...
From physiology to pathology: the role of mitochondria in acute kidney injuries and chronic kidney diseases
From physiology to pathology: the role of mitochondria in acute kidney injuries and chronic kidney diseases
Background: Renal diseases remain an increasing public health issue affecting millions of people. The kidney is a highly e...
Therapeutic potential targeting podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis
Therapeutic potential targeting podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis
Background：Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration...
Develop and Validate a Risk Score in Predicting Renal Failure in Focal Segmental Glomerulosclerosis
Develop and Validate a Risk Score in Predicting Renal Failure in Focal Segmental Glomerulosclerosis
Introduction The aim of this study is to develop and validate a risk score for end stage kidney disease (ESKD) in patients...
Role of IL-6 family cytokines in organ fibrosis
Role of IL-6 family cytokines in organ fibrosis
Background: Organ fibrosis remains an important cause of high incidence rate and mortality worldwide. The prominent role o...
Hospitalizations of chronic dialysis patients: a national study in China
Hospitalizations of chronic dialysis patients: a national study in China
Background Patients receiving chronic dialysis are usually with multiple comorbidities and at high-risk for hospitalizatio...
Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor
Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor
Introduction: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal disease, has complex pathogenic ...
A panoramic view of ferroptosis in cardiovascular disease
A panoramic view of ferroptosis in cardiovascular disease
Background: Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-depen...
Impact of Angiopoietin-2 on Kidney Diseases
Impact of Angiopoietin-2 on Kidney Diseases
<b><i>Background:</i></b> Angiopoietins (Ang) are essential angiogenic factors involved in angioge...
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