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Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced AKI
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced AKI
Background Cisplatin is an effective chemotherapy agent for a wide variety of solid tumors, but i
Oral Sodium Bicarbonate and Bone Turnover in CKD: A Secondary Analysis of the BASE Pilot Trial
Oral Sodium Bicarbonate and Bone Turnover in CKD: A Secondary Analysis of the BASE Pilot Trial
Background Treatment with alkali has been hypothesized to improve bone health in CKD by mitigatin
Dicarboxylic Acid Dietary Supplementation Protects Against Acute Kidney Injury
Dicarboxylic Acid Dietary Supplementation Protects Against Acute Kidney Injury
Introduction: Proximal tubules are rich in peroxisomes, which are damaged during AKI. Previous st
Prognostic Biomarkers in Kidney Transplantation: a Systematic Review and Critical Appraisal
Prognostic Biomarkers in Kidney Transplantation: a Systematic Review and Critical Appraisal
Background Despite the increasing number of biomarker studies published in the transplant literat
Racial and Ethnic Diversity is a Tool for Eliminating Unequal Racial and Ethnic Kidney Health
Racial and Ethnic Diversity is a Tool for Eliminating Unequal Racial and Ethnic Kidney Health
Dell Medical School, The University of Texas at Austin, Austin, TX Correspondence: Dr. Donald E. Wesson, Dell...
The B1 H+-ATPase (Atp6v1b1) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis
The B1 H+-ATPase (Atp6v1b1) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis
Background: Non-type-A intercalated cells (IC) in the collecting duct system express the luminal
Does Serum Creatinine Reflect Muscle Mass in Patients with Kidney Failure?
Does Serum Creatinine Reflect Muscle Mass in Patients with Kidney Failure?
1Section of Nephrology, Selzman Institute for Kidney Health, Baylor College of Medicine, Houston, Texas 2Sect...
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury
Background: Cisplatin is an effective chemotherapy agent for a wide variety of solid tumors, but
Impact of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort
Impact of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort
Background: Excess mortality in hemodialysis patients is largely due to cardiovascular disease an
Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease
Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder characte
State of the Science and Ethical Considerations for Preimplantation Genetic Testing for Monogenic Cystic Kidney Diseases and Ciliopathies
State of the Science and Ethical Considerations for Preimplantation Genetic Testing for Monogenic Cystic Kidney Diseases and Ciliopathies
There is a broad phenotypic spectrum of monogenic polycystic kidney diseases (PKD). These disorders
Navigating the Omics Frontier: Challenges, Opportunities, and the Future of Precision Nephrology
Navigating the Omics Frontier: Challenges, Opportunities, and the Future of Precision Nephrology
1Department of Biomedicine, Aarhus University, Aarhus, Denmark 2III Department of Medicine, University Medica...
Our Editorial Fellowship Program: Building Synergism
Our Editorial Fellowship Program: Building Synergism
Department of Physiology, Keck School of Medicine, University of Southern California, Los Angeles, California ...
The COVID-19 Pandemic: A Special Challenge for the Journal's Editors
The COVID-19 Pandemic: A Special Challenge for the Journal's Editors
The coronavirus disease 2019 (COVID-19) not only had a major impact on patient care and on the mental health of patients a...
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS—Like Zebrafish Model
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS—Like Zebrafish Model
Background FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss
Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations
Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations
Significance Statement Kidney stone disease is a common disorder with poorly understood pathophys
Development and Validation of a New Hierarchical Composite End Point for Clinical Trials of Kidney Disease Progression
Development and Validation of a New Hierarchical Composite End Point for Clinical Trials of Kidney Disease Progression
Background The established composite kidney end point in clinical trials combines clinical events
Effect of SGLT2 Inhibitors on Discontinuation of Renin–angiotensin System Blockade: A Joint Analysis of the CREDENCE and DAPA-CKD Trials
Effect of SGLT2 Inhibitors on Discontinuation of Renin–angiotensin System Blockade: A Joint Analysis of the CREDENCE and DAPA-CKD Trials
Background Strategies to enable persistent use of renin–angiotensin system (RAS) blockade to impr
Validity and Utility of a Hierarchical Composite End Point for Clinical Trials of Kidney Disease Progression: A Review
Validity and Utility of a Hierarchical Composite End Point for Clinical Trials of Kidney Disease Progression: A Review
Clinical trials in nephrology often use composite end points comprising clinical events, such as ons
Peritoneal dialysis catheter complications after insertion by surgeons, radiologists, or nephrologists
Peritoneal dialysis catheter complications after insertion by surgeons, radiologists, or nephrologists
Background: The US government has implemented incentives to increase the use of peritoneal dialys
Erratum: Tubular and Glomerular Size by Cortex Depth as Predictors for Progressive Chronic Kidney Disease after Radical Nephrectomy for Tumor
Erratum: Tubular and Glomerular Size by Cortex Depth as Predictors for Progressive Chronic Kidney Disease after Radical Nephrectomy for Tumor
ErratumJournal of the American Society of Nephrology | DOI: 10.1681/ASN.0000000000000228 Metrics ...
Initial Management and Potential Opportunities to Deprescribe Dialysis among Patients with AKI-D Patients after Hospital Discharge
Initial Management and Potential Opportunities to Deprescribe Dialysis among Patients with AKI-D Patients after Hospital Discharge
1Division of Nephrology, University of California San Francisco, San Francisco, California 2Satellite Healthc...
Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease
Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease
Significance Statement African Americans are at increased risk of CKD in part due to high-risk (H
Validity and Utility of a Hierarchical Composite Endpoint for Clinical Trials of Kidney Disease Progression: A Review
Validity and Utility of a Hierarchical Composite Endpoint for Clinical Trials of Kidney Disease Progression: A Review
Clinical trials in nephrology often use composite end points comprising clinical events, such as ons
WIN is Turning 40
WIN is Turning 40
Women in Nephrology (WIN) was founded in 1983, 40 years ago. This anniversary deserves celebration, an occasion to acknowl...
Muscle Mass and Serum Creatinine Concentration by Race and Ethnicity Among Hemodialysis Patients
Muscle Mass and Serum Creatinine Concentration by Race and Ethnicity Among Hemodialysis Patients
Background: Differences in serum creatinine concentration among groups defined by race and ethnic
Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations
Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations
Background: Kidney stone disease affects approximately 10% of individuals in their lifetime and i
Treatment of IgA nephropathy: a rapidly evolving field
Treatment of IgA nephropathy: a rapidly evolving field
The pivotal event in the pathophysiology of IgA nephropathy is the binding of circulating IgA-contai
Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy
Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy
Significance Statement Genome-wide association studies have identified nearly 20 IgA nephropathy
CKD-EPI and EKFC GFR Estimating Equations: Performance and Other Considerations for Selecting Equations for Implementation in Adults
CKD-EPI and EKFC GFR Estimating Equations: Performance and Other Considerations for Selecting Equations for Implementation in Adults
Background: New CKD-EPI and EKFC estimated GFR (eGFR) equations using creatinine (eGFRcr), cystat
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