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Small but relevant effects of exercise therapy in osteoarthritis
Evidence for the effectiveness of exercise in osteoarthritis, particularly the long-term benefit, remains unclear. Now, a ...
Sex and gender differences in rheumatology: clinical impact and future directions
Sex and gender shape disease presentation, diagnostic accuracy, treatment response and clinical outcomes in rheumatology, ...
The gut–joint axis in osteoarthritis
The gut–joint axis in osteoarthritis
Osteoarthritis (OA) is a complex condition driven by biomechanical, metabolic and inflammatory factors; however, effective...
Adjunctive glucocorticoids in Kawasaki disease
In a phase III trial, the addition of glucocorticoids to standard therapy did not prevent the development of coronary arte...
Brepocitinib shows promise for dermatomyositis
Positive results of the phase III VALOR trial suggest that the TYK2–JAK1 inhibitor brepocitinib is safe and effectiv...
Senotherapeutics suppress disc degeneration
In mice with early-onset disc degeneration, treatment with dasatinib and quercetin suppressed senescence-associated signal...
T cells mediate tissue damage in lupus nephritis
Findings reveal that stem-like CD8+ T cells migrate from renal lymph nodes and cause tissue damage in lupus nephritis.
Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution
Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution
Innate lymphoid cells (ILCs) are emerging as critical modulators of inflammation in rheumatoid arthritis, contributing to ...
The epidemiology of RA
Analysis of regional variations in the epidemiology of rheumatoid arthritis (RA) over the past 40 years indicates that the...
Reply to ‘Inborn errors of immunity and AAV: a complex picture’
Gül, A. et al. The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis. Nat. Rev. Rheumato...
Inborn errors of immunity and AAV: a complex picture
Gül, A. et al. The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis. Nat. Rev. Rheumato...
Global epidemiology of spondyloarthritis
Global epidemiology of spondyloarthritis
The worldwide epidemiology of axial spondyloarthritis (axSpA), psoriatic arthritis (PsA) and peripheral spondyloarthritis,...
A 20-year reflection on women in rheumatology
The collective priorities of the rheumatology field represent the lived experience, and therefore diversity of its members...
A firm grip on hand OA: 20 years of progress and prospects
In the past two decades the field of hand osteoarthritis (OA) has moved from resignation to action. Despite progress, such...
20 years of Nature Reviews Rheumatology
Both rheumatology and the publishing environment have seen tremendous changes over the past two decades. Here, the first E...
Author Correction: Parathyroid hormone receptor agonists in the management of osteoporosis
MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UKNicholas Fuggle, Elizabeth M. Curtis, Cyrus ...
Piezo1 as a therapeutic target for glucocorticoid-induced osteoporosis
A study implicates the Hes1–Piezo1 signalling pathway in osteocytes in the pathogenesis of glucocorticoid-induced os...
Opportunities and limitations of B cell depletion approaches in SLE
Opportunities and limitations of B cell depletion approaches in SLE
B cell depletion with rituximab, a chimeric monoclonal antibody that selectively targets B cells by binding CD20, has been...
Virome associations in autoimmunity and COVID-19
Virome associations in autoimmunity and COVID-19
The detection of anellovirus or eHHV-6B genomes in the blood virome seems to correlate with the risk or severity of rheuma...
T cells in Sjögren disease
T cells in Sjögren disease
A mouse model that reflects Sjögren disease in humans provides insights into the role of regulatory T cells and type ...
Occupational dust and chemical exposures and the development of autoimmune rheumatic diseases
Occupational dust and chemical exposures and the development of autoimmune rheumatic diseases
Although the association between certain occupational exposures and the development of autoimmune rheumatic disease was fi...
Genome-wide mutagenesis reported in systemic sclerosis
Genome-wide mutagenesis reported in systemic sclerosis
The mechanisms that drive the diverse disease manifestations and increased cancer risk associated with systemic sclerosis ...
Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies
Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies
Advances in T cell receptor (TCR) profiling techniques have substantially improved our ability to investigate T cell respo...
A direct link between SARS-CoV-2 and bone loss
Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral...
Biological and clinical roles of IL-18 in inflammatory diseases
Biological and clinical roles of IL-18 in inflammatory diseases
Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is a...
Nanohybrid therapy hits multiple arthritis targets
A novel combination of ceria nanoparticles and mesenchymal stem cell nanovesicles modified both inflammation and autoimmun...
Shifting the SLE management paradigm: challenges and implications
Shifting the SLE management paradigm: challenges and implications
Newly published European guidelines for the management of systemic lupus erythematosus (SLE) and lupus nephritis, specific...
Primary care rheumatology: towards sustainable development in health
Globally, rheumatic musculoskeletal diseases constitute the most common causes of disability, related morbidity and econom...
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of derm...
Profiling joint tissues at single-cell resolution: advances and insights
Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organiza...
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