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Piezo1 as a therapeutic target for glucocorticoid-induced osteoporosis
A study implicates the Hes1–Piezo1 signalling pathway in osteocytes in the pathogenesis of glucocorticoid-induced os...
Opportunities and limitations of B cell depletion approaches in SLE
Opportunities and limitations of B cell depletion approaches in SLE
B cell depletion with rituximab, a chimeric monoclonal antibody that selectively targets B cells by binding CD20, has been...
Virome associations in autoimmunity and COVID-19
Virome associations in autoimmunity and COVID-19
The detection of anellovirus or eHHV-6B genomes in the blood virome seems to correlate with the risk or severity of rheuma...
T cells in Sjögren disease
T cells in Sjögren disease
A mouse model that reflects Sjögren disease in humans provides insights into the role of regulatory T cells and type ...
Occupational dust and chemical exposures and the development of autoimmune rheumatic diseases
Occupational dust and chemical exposures and the development of autoimmune rheumatic diseases
Although the association between certain occupational exposures and the development of autoimmune rheumatic disease was fi...
Genome-wide mutagenesis reported in systemic sclerosis
Genome-wide mutagenesis reported in systemic sclerosis
The mechanisms that drive the diverse disease manifestations and increased cancer risk associated with systemic sclerosis ...
Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies
Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies
Advances in T cell receptor (TCR) profiling techniques have substantially improved our ability to investigate T cell respo...
A direct link between SARS-CoV-2 and bone loss
Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral...
Biological and clinical roles of IL-18 in inflammatory diseases
Biological and clinical roles of IL-18 in inflammatory diseases
Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is a...
Nanohybrid therapy hits multiple arthritis targets
A novel combination of ceria nanoparticles and mesenchymal stem cell nanovesicles modified both inflammation and autoimmun...
Shifting the SLE management paradigm: challenges and implications
Shifting the SLE management paradigm: challenges and implications
Newly published European guidelines for the management of systemic lupus erythematosus (SLE) and lupus nephritis, specific...
Primary care rheumatology: towards sustainable development in health
Globally, rheumatic musculoskeletal diseases constitute the most common causes of disability, related morbidity and econom...
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of derm...
Profiling joint tissues at single-cell resolution: advances and insights
Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organiza...
Targeted NOD2 sequencing uncovers JIA misdiagnosis
New findings support the use of targeted next-generation sequencing of NOD2 to reassess the diagnosis of juvenile idiopath...
Single-cell atlas unveils the diversity of RA synovial tissue
Researchers have conducted a comprehensive single-cell analysis of synovial tissue in rheumatoid arthritis, providing insi...
Multi-omics reveals distinct MPA subtypes
Using multi-omics analyses, researchers have identified two distinct immunological phenotypes of microscopic polyangiitis,...
l-arginine inhibits arthritis and bone loss by reprogramming osteoclast metabolism
New research shows that the amino acid l-arginine ameliorates arthritis and inhibits inflammatory bone loss by altering en...
Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis
Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis
Since the original description of spondyloarthritis 50 years ago, results have demonstrated similarities and differences b...
25 years of biologic DMARDs in rheumatology
25 years of biologic DMARDs in rheumatology
2023 marks 25 years since the approval of the first biologic drug in rheumatology. In this Viewpoint, five rheumatology re...
Immune mechanisms of depression in rheumatoid arthritis
Immune mechanisms of depression in rheumatoid arthritis
Depression is a common and disabling comorbidity in rheumatoid arthritis that not only decreases the likelihood of remissi...
Systemic sclerosis interstitial lung disease: unmet needs and potential solutions
Systemic sclerosis interstitial lung disease: unmet needs and potential solutions
Systemic sclerosis (SSc), or scleroderma, is a rare, complex, systemic autoimmune disease of unknown aetiology, characteri...
Treatment of systemic juvenile idiopathic arthritis
Treatment of systemic juvenile idiopathic arthritis
Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory disease with hallmarks of severe systemic inflammation, w...
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years precedin...
Methotrexate improves pain in hand OA
Methotrexate reduces pain and stiffness in hand osteoarthritis with synovitis, according to the results of a new randomize...
Are TNF inhibitors still the agent of choice for RA?
Since entering the clinic 25 years ago, biologic TNF inhibitors have transformed the outlook for people with rheumatoid ar...
Epidemiology of the idiopathic inflammatory myopathies
Epidemiology of the idiopathic inflammatory myopathies
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic autoimmune diseases that affect the sk...
Rheumatoid arthritis prevention in arthralgia: fantasy or reality?
Rheumatoid arthritis prevention in arthralgia: fantasy or reality?
The concept of a ‘window of opportunity’ in treating a disease assumes the existence of a time frame during wh...
Pre-exposure prophylaxis reduces risk of COVID-19
In an observational study, SARS-CoV-2 antibody therapy used as pre-exposure prophylaxis reduced the incidence of COVID-19 ...
FGF signalling implicated in relapsing RA
New research shows that the FGF10–FGFR1 axis is highly activated in lining fibroblast-like synoviocytes during relap...
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