Autoreactive T cells are associated with Sjögren disease (SjD, also known as Sjögren syndrome), but their role in disease pathogenesis is unclear. The store-operated calcium entry pathway is important for the function of T cells, and the calcium sensors STIM1 and STIM2 are involved in mediating this pathway.

As the SjD-like phenotype of Stim1/2Foxp3 mice reflects human SjD, this model could be used to test new treatments.