Gravallese, E. M. & Firestein, G. S. Rheumatoid arthritis - common origins, divergent mechanisms. N. Engl. J. Med. 388, 529–542 (2023).
Article CAS PubMed Google Scholar
Larid, G., Vix, J., Garlantezec, R., Loppin, E. & Gervais, E. Increased remission with fewer corticosteroids and more biologics in rheumatoid arthritis at 7-year follow-up in real-life conditions. Sci. Rep. 12, 2563 (2022).
Article CAS PubMed PubMed Central Google Scholar
Lillegraven, S. et al. Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial. Ann. Rheum. Dis. 82, 1394–1403 (2023).
Article CAS PubMed PubMed Central Google Scholar
Jarvinen, P. & Aho, K. Twin studies in rheumatic diseases. Semin. Arthritis Rheum. 24, 19–28 (1994).
Article CAS PubMed Google Scholar
Bach, J. F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347, 911–920 (2002).
Gianfrancesco, M. A. et al. Smoking is associated with higher disease activity in rheumatoid arthritis: a longitudinal study controlling for time-varying covariates. J. Rheumatol. 46, 370–375 (2019).
Article CAS PubMed Google Scholar
Konig, M. F. et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci. Transl. Med. 8, 369ra176 (2016).
Article PubMed PubMed Central Google Scholar
Schmajuk, G., Trupin, L., Yelin, E. & Blanc, P. D. Prevalence of arthritis and rheumatoid arthritis in coal mining counties of the United States. Arthritis Care Res. 71, 1209–1215 (2019).
Brusca, S. B., Abramson, S. B. & Scher, J. U. Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity. Curr. Opin. Rheumatol. 26, 101–107 (2014).
Article CAS PubMed PubMed Central Google Scholar
Arrieta, M. C. et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 7, 307ra152 (2015).
Ivanov, I. I. et al. Induction of Intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485–498 (2009).
Article CAS PubMed PubMed Central Google Scholar
Wu, H. J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815–827 (2010).
Article CAS PubMed PubMed Central Google Scholar
Vivier, E. et al. Innate lymphoid cells: 10 years on. Cell 174, 1054–1066 (2018).
Article CAS PubMed Google Scholar
Clottu, A. S., Humbel, M., Fluder, N., Karampetsou, M. P. & Comte, D. Innate lymphoid cells in autoimmune diseases. Front. Immunol. 12, 789788 (2021).
Article CAS PubMed Google Scholar
Kabil, A. et al. Microbial intestinal dysbiosis drives long-term allergic susceptibility by sculpting an ILC2-B1 cell-innate IgE axis. J. Allergy Clin. Immunol. 154, 1260–1276.e9 (2024).
Article CAS PubMed Google Scholar
Kabil, A. K. et al. Early-life microbiota skews long-term gene expression and chromatin states of bone marrow hematopoietic precursors. Cell Rep. 45, 116871 (2026).
Article CAS PubMed Google Scholar
Kabil, A. K. et al. Microbial dysbiosis sculpts a systemic ILC3/IL-17 axis governing lung inflammatory responses and central hematopoiesis. Mucosal Immunol. 1139–1158, https://doi.org/10.1016/j.mucimm.2025.07.002 (2025).
Eberl, G., Colonna, M., Di Santo, J. P. & McKenzie, A. N. Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology. Science 348, aaa6566 (2015).
Article PubMed PubMed Central Google Scholar
Cherrier, M. & Eberl, G. The development of LTi cells. Curr. Opin. Immunol. 24, 178–183 (2012).
Article CAS PubMed Google Scholar
Shin, S. B. & McNagny, K. M. ILC-You in the thymus: a fresh look at innate lymphoid cell development. Front. Immunol. 12, 681110 (2021).
Article CAS PubMed PubMed Central Google Scholar
Jan-Abu, S. C., Kabil, A. & McNagny, K. M. Parallel origins and functions of T cells and ILCs. Clin. Exp. Immunol. 213, 76–86 (2023).
Article PubMed PubMed Central Google Scholar
von Moltke, J., Ji, M., Liang, H. E. & Locksley, R. M. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529, 221–225 (2016).
Gold, M. J. et al. Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures. J. Allergy Clin. Immunol. 133, 1142–1148 (2014).
Article CAS PubMed Google Scholar
Halim, T. Y., Krauss, R. H., Sun, A. C. & Takei, F. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36, 451–463 (2012).
Article CAS PubMed Google Scholar
Halim, T. Y. et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40, 425–435 (2014).
Article CAS PubMed PubMed Central Google Scholar
Schneider, C. et al. Tissue-Resident Group 2 innate lymphoid cells differentiate by layered ontogeny and in situ perinatal priming. Immunity 50, 1425–1438.e5 (2019).
Article CAS PubMed PubMed Central Google Scholar
Panda, S. K. & Colonna, M. Innate lymphoid cells in mucosal immunity. Front. Immunol. 10, 861 (2019).
Article CAS PubMed PubMed Central Google Scholar
Wang, X. et al. Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors. Sci. Immunol. 10, eadu7962 (2025).
Article CAS PubMed Google Scholar
Ghaedi, M. & Takei, F. Innate lymphoid cell development. J. Allergy Clin. Immunol. 147, 1549–1560 (2021).
Article CAS PubMed Google Scholar
Simic, M. et al. Distinct waves from the hemogenic endothelium give rise to layered lymphoid tissue inducer cell ontogeny. Cell Rep. 32, 108004 (2020).
Article CAS PubMed Google Scholar
Ding, Y. et al. Distinct developmental pathways generate functionally distinct populations of natural killer cells. Nat. Immunol. 25, 1183–1192 (2024).
Article CAS PubMed PubMed Central Google Scholar
Harly, C. et al. The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat. Immunol. 20, 1150–1160 (2019).
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