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The Geoepidemiology of Autoimmune Hepatitis
The Geoepidemiology of Autoimmune Hepatitis
Autoimmune hepatitis (AIH) is typically a chronic, inflammatory, and progressive liver disease of autoimmune origin. Curre...
Heterogeneity in Atopic Dermatitis: Ethnic, Anatomical Site, and Age-related Variations
Heterogeneity in Atopic Dermatitis: Ethnic, Anatomical Site, and Age-related Variations
Atopic dermatitis (AD) is a chronic, systematic inflammatory dermatosis with a high prevalence worldwide, characterized by...
Cytoreduction is a Valid Option for Treatment and Prevention of Anaphylaxis in Systemic Mastocytosis: Case Report and Literature Review
Cytoreduction is a Valid Option for Treatment and Prevention of Anaphylaxis in Systemic Mastocytosis: Case Report and Literature Review
Systemic mastocytosis (SM) is a myeloproliferative disorder marked by accumulation of clonal mast cells (MC) and a 100-fol...
Precision Medicine in Plant Food Allergy: a Systematic Review of Biomarkers Under a Clinical Approach
Precision Medicine in Plant Food Allergy: a Systematic Review of Biomarkers Under a Clinical Approach
Plant food allergy (FA) is a major global health problem, being peanut one of the most studied allergenic foods worldwide....
Proposition for a New Classification of Hypersensitivity Reactions – an Expanded Nomenclature
Proposition for a New Classification of Hypersensitivity Reactions – an Expanded Nomenclature
Diseases associated with hypersensitivity reactions (HRs) are extremely common and can affect the quality of life of milli...
Correction to: Atopic Comorbidities and Topical Steroids in Early Childhood Atopic Dermatitis: Are We Missing a Piece of the Puzzle?
Correction to: Atopic Comorbidities and Topical Steroids in Early Childhood Atopic Dermatitis: Are We Missing a Piece of the Puzzle?
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Environmental Pollutants and Food Allergy: From Traditional Triggers to Emerging Hazards
Environmental Pollutants and Food Allergy: From Traditional Triggers to Emerging Hazards
Food allergy (FA) is a serious public health concern characterized by a rising global prevalence. This rapid increase, obs...
Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes
Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes
Atopic dermatitis (AD) is a highly prevalent, chronic inflammatory skin disease that predominantly begins in early childho...
Assessing Patient-Reported Outcomes in Acute Attacks of Hereditary Angioedema: Insights from a Mixed Methods Study of Participants Receiving Standard-of-Care Treatments in a Real-World Setting
Assessing Patient-Reported Outcomes in Acute Attacks of Hereditary Angioedema: Insights from a Mixed Methods Study of Participants Receiving Standard-of-Care Treatments in a Real-World Setting
Hereditary angioedema (HAE) is a rare, genetic condition characterized by recurrent, unpredictable tissue swelling attacks...
Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks
Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks
Amidst the exponential rise in crustacean production and consumption across East Asia, the population burden of crustacean...
The Roles of Interleukin-18 in Inflammation and Autoimmune Disease
The Roles of Interleukin-18 in Inflammation and Autoimmune Disease
Interleukin-18 (IL-18) is a member of the IL-1 cytokine family with significant homology to IL-1β. New emerging evide...
The Application of Single-cell RNA Sequencing Technology in the Research of Sino-Nasal Diseases
The Application of Single-cell RNA Sequencing Technology in the Research of Sino-Nasal Diseases
Single-cell RNA sequencing (scRNA-seq) has revolutionized rhinology by enabling the high-resolution dissection of nasal pa...
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes
The expression of the ionotropic glutamate receptors AMPAR and NMDAR has been measured on circulating leucocytes, particul...
Clinical Factors Associated with Genetically Confirmed Inborn Errors of Immunity in Children Presenting with Immune Dysregulation
Clinical Factors Associated with Genetically Confirmed Inborn Errors of Immunity in Children Presenting with Immune Dysregulation
Inborn errors of immunity (IEI) are increasingly recognized as important underlying causes of immune dysregulation in chil...
Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus
Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus
Olfactory dysfunction (OD) secondary to chronic rhinosinusitis (CRS) significantly impairs quality of life by hindering th...
Evolving Therapeutic Strategies in ANCA-Associated Vasculitis: Current Standards and Emerging Targets for GPA and MPA
Evolving Therapeutic Strategies in ANCA-Associated Vasculitis: Current Standards and Emerging Targets for GPA and MPA
Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are severe autoimmune disorders characterized by...
Unmasking the Impact of Air Pollution on Allergic Rhinitis
Unmasking the Impact of Air Pollution on Allergic Rhinitis
Allergic rhinitis (AR) is a chronic, non-infectious inflammatory condition of the nasal mucosa, primarily mediated by immu...
Mouse Models of Food Allergies: Where Do They Take Us?
Mouse Models of Food Allergies: Where Do They Take Us?
The rising prevalence of food allergies has coincided with the increasing use of animal models to study disease mechanisms...
A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside
A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. IL-10 receptor (IL-10R) consists of two chains of ligand-bi...
Therapeutic Potential of Tulisokibart and Anti-TL1A Therapy in Inflammatory Disorders: Current Insights and Future Directions
Therapeutic Potential of Tulisokibart and Anti-TL1A Therapy in Inflammatory Disorders: Current Insights and Future Directions
Tumor necrosis factor-like cytokine 1 A (TL1A), encoded by the TNFSF15 gene, is expressed on multiple cells, incl...
Down Syndrome and Autoimmune Disease
Down Syndrome and Autoimmune Disease
Down syndrome is the most common genetic cause of intellectual disability and has previously been associated with a variet...
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Autoimmune diseases (AIDs) are complex in etiology and diverse in classification but clinically show similar symptoms such...
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate immune cell functions, particularly m...
Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics
Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics
Fibroblasts are crucial components of the skin structure. They were traditionally believed to maintain the skin’s st...
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic dermatitis and psoriasis are common chronic inflammatory diseases of high incidence that share some clinical featur...
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory...
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen-based diagnostics are essential in the management algorithm of allergic diseases. Unlike systemic allergy, where ...
Advancements in the Study of the Immune Molecule NKp46 in Immune System-related Diseases
Advancements in the Study of the Immune Molecule NKp46 in Immune System-related Diseases
NKp46 is a natural killer cell activating receptor primarily expressed on NK cells and non-NK innate lymphoid cells. In th...
Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
Long-term prophylaxis (LTP) has been shown to reduce the frequency of hereditary angioedema (HAE) attacks; however, attack...
Neutrophils in Atopic Dermatitis
Neutrophils in Atopic Dermatitis
Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain typ...
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