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Mast Cell Mediators and Their Diagnostic Utility in Clonal and Nonclonal Mast Cell Activation Disorders
Mast Cell Mediators and Their Diagnostic Utility in Clonal and Nonclonal Mast Cell Activation Disorders
Systemic mastocytosis and mast cell activation syndromes rely on serum and urine mediators and mediator metabolites for di...
When Hormones Attack: A Literature Review of Progesterone-Induced Anaphylaxis
When Hormones Attack: A Literature Review of Progesterone-Induced Anaphylaxis
Progesterone hypersensitivity is a rare and underdiagnosed condition whose incidence is expected to rise due to the increa...
Severe Asthma Patients’ Characteristics in Mexico Versus International Severe Asthma Registry (ISAR) Global
Severe Asthma Patients’ Characteristics in Mexico Versus International Severe Asthma Registry (ISAR) Global
The International Severe Asthma (SA) Registry (ISAR) started in 2017. Mexico joint in 2019. ISAR global patients have been...
Psychophysical Olfactory Outcomes After Biologic Therapy for Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Meta-Analysis
Psychophysical Olfactory Outcomes After Biologic Therapy for Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Meta-Analysis
Smell loss is among the most debilitating symptoms of chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to synth...
Understanding Biologics in CRSwNP: Related Events and Insights
Understanding Biologics in CRSwNP: Related Events and Insights
This review examines the immunologic and clinical considerations surrounding biologic therapy for chronic rhinosinusitis w...
A Parade of Persistent and Emerging Contact Allergens – A Clinical Update
A Parade of Persistent and Emerging Contact Allergens – A Clinical Update
Clinical management of allergic contact dermatitis (ACD) is increasingly challenging due to the growing number of allergen...
Beyond Triple Therapy: Anti-Type 2 Biologic Therapies for Eosinophilic COPD and Respiratory Comorbidities - a Review of Clinical Evidence
Beyond Triple Therapy: Anti-Type 2 Biologic Therapies for Eosinophilic COPD and Respiratory Comorbidities - a Review of Clinical Evidence
To review current evidence on biologic therapies targeting type 2 inflammation in patients with eosinophilic COPD and resp...
Current Status of Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes along Human Health Risk Assessment Steps
Current Status of Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes along Human Health Risk Assessment Steps
This review aims to summarize the effects of per- and poly-fluoroalkyl substances (PFAS) exposures on the lung, emphasizin...
Epithelial Barrier Dysfunction in Atopic Dermatitis, Allergic Contact Dermatitis, and Chronic Spontaneous Urticaria and its Therapeutic Implications
Epithelial Barrier Dysfunction in Atopic Dermatitis, Allergic Contact Dermatitis, and Chronic Spontaneous Urticaria and its Therapeutic Implications
Allergic skin diseases arise from complex interactions between epithelial barrier dysfunction and immune dysregulation. Th...
Interception of Regulatory RNAs on TGF-β Signaling in the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Systematic Review
Interception of Regulatory RNAs on TGF-β Signaling in the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Systematic Review
Idiopathic Pulmonary Fibrosis is a type of interstitial lung disease characterized by lung scarring due to excessive extra...
The Emerging Role of Ly6G⁺Nur77⁺ Lung Macrophages in Type-2 Allergic Inflammation: A Comprehensive Review on Asthma Pathogenesis
The Emerging Role of Ly6G⁺Nur77⁺ Lung Macrophages in Type-2 Allergic Inflammation: A Comprehensive Review on Asthma Pathogenesis
Asthma remains a major health challenge affecting over 300 million people worldwide, with severe, steroid-resista...
MicroRNAs as current diagnostic biomarkers and potential therapeutic targets in allergic and non-allergic rhinitis – A functional characterization
MicroRNAs as current diagnostic biomarkers and potential therapeutic targets in allergic and non-allergic rhinitis – A functional characterization
Allergic rhinitis affects up to one-quarter of the population in industrialized countries. This chronic inflammatory disea...
Pharmacotherapeutic Medication Adherence in Patients With Allergic Rhinitis: A Systematic Review and Meta-Analysis
Pharmacotherapeutic Medication Adherence in Patients With Allergic Rhinitis: A Systematic Review and Meta-Analysis
Medication adherence is essential for effective management of allergic rhinitis (AR), yet real-world adherence to guidelin...
Aeroallergens in Atopic Dermatitis and Chronic Urticaria
Aeroallergens in Atopic Dermatitis and Chronic Urticaria
Aeroallergens are well established triggers of allergic rhinitis and asthma, yet their contribution to allergic skin disea...
Correction: Understanding Biologics in CRSwNP: Related Events and Insights
Correction: Understanding Biologics in CRSwNP: Related Events and Insights
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Impact of IL-4/IL-13 Blockade with Dupilumab on the Microbiome in Type 2 Inflammatory Diseases: A Systematic Review
Impact of IL-4/IL-13 Blockade with Dupilumab on the Microbiome in Type 2 Inflammatory Diseases: A Systematic Review
To systematically review current evidence on microbiota changes associated with dupilumab treatment across different anato...
Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences
Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences
This review aims to clarify the early-life risk and protective factors associated with Infantile Atopic Dermatitis (IAD)&#...
The Role of the Indoor Exposome in Food Allergy Development
The Role of the Indoor Exposome in Food Allergy Development
Due to the rapid rise in the prevalence of food allergy, environmental exposures, in addition to genetic susceptibility, a...
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
There is an incomplete understanding regarding the extent of endoscopic sinus surgery (ESS) in managing chronic rhinosinus...
Getting in Shape: Updates in Exercise Anaphylaxis
Getting in Shape: Updates in Exercise Anaphylaxis
Exercise induced anaphylaxis (EIA) can be difficult to diagnose due to the interplay of co-factors on clinical presentatio...
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Clinical interest in non-IgE activation of mast cells has been growing since the description of the human MRGPRX2 receptor...
Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Effect of Treatment with Emphasis on Biological Therapy
Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Effect of Treatment with Emphasis on Biological Therapy
Olfactory dysfunction significantly impacts quality of life that affects a majority of the patients with chronic rhinosinu...
Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps
Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps
Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithel...
Effects of Food Processing on Allergenicity
Effects of Food Processing on Allergenicity
There is an increasing awareness among clinicians that industrial and household food processing methods can increase or de...
Parosmia: Pathophysiology and Management
Parosmia: Pathophysiology and Management
Parosmia is a qualitative olfactory disorder in which there is a mismatch between the memory of an odor and the actual exp...
The Impact of the Indoor Environment on Childhood Asthma
The Impact of the Indoor Environment on Childhood Asthma
This manuscript reviews the impact of important indoor environmental exposures on pediatric asthma, with a focus on recent...
Hypersensitivity Reactions to Anticonvulsants
Hypersensitivity Reactions to Anticonvulsants
Antiepileptics are the mainstay of treatment for seizure management. Immediate and delayed hypersensitivity reactions asso...
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory condition that significantly impacts qual...
Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Chronic spontaneous urticaria and chronic inducible urticaria (CSU/CindU) are caused by mast cell and basophil activation ...
The Impact of Ambient and Wildfire Air Pollution on Rhinosinusitis and Olfactory Dysfunction
The Impact of Ambient and Wildfire Air Pollution on Rhinosinusitis and Olfactory Dysfunction
With increasing industrialization, exposure to ambient and wildfire air pollution is projected to increase, necessitating ...
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