Pharmacotherapeutic Medication Adherence in Patients With Allergic Rhinitis: A Systematic Review and Meta-Analysis

Wheatley LM, Togias A. Allergic rhinitis. N Engl J Med. 2015;372(5):456–63. https://doi.org/10.1056/NEJMcp1412282.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008*. Allergy. 2008;63(s86):8–160. https://doi.org/10.1111/j.1398-9995.2007.01620.x.

Article  PubMed  Google Scholar 

Sousa‐Pinto B, Costa EM, Vieira RJ, Klimek L, Czarlewski W, Pfaar O, et al. Adherence to treatment in allergic rhinitis during the pollen season in Europe: a mask‐air study. Clin Exp Allergy. 2025;55(3):226–38. https://doi.org/10.1111/cea.70004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sur DKC, Plesa ML. Treatment of allergic rhinitis. Am Fam Physician. 2015;92(11):985–92.

PubMed  Google Scholar 

Weaver-Agostoni J, Kosak Z, Bartlett S. Allergic rhinitis: rapid evidence review. Am Fam Physician. 2023;107(5):466–73.

PubMed  Google Scholar 

Abdullah B, Zahedi FD, Hamizan A, Husain S. Medication adherence, sensory attributes, and adverse effects of intranasal corticosteroids in allergic rhinitis patients: a systematic review and meta-analysis. Asian Pac J Allergy Immunol. 2025;43(2):151–67. https://doi.org/10.12932/AP-040424-1834.

Article  CAS  PubMed  Google Scholar 

Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67–74. https://doi.org/10.1097/00005650-198601000-00007.

Article  CAS  PubMed  Google Scholar 

Steenis MV, Driesenaar JA, Bensing JM, Hulten RV, Souverein PC, Dijk LV, et al. Relationship between medication beliefs, self-reported and refill adherence, and symptoms in patients with asthma using inhaled corticosteroids. Patient Prefer Adherence. 2014;8:83–91. https://doi.org/10.2147/PPA.S44185.

Article  PubMed  PubMed Central  Google Scholar 

Ng CL, Wang DY. Latest developments in allergic rhinitis in Allergy for clinicians and researchers. Allergy. 2015;70(12):1521–30. https://doi.org/10.1111/all.12782.

Article  CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71.

Article  PubMed  PubMed Central  Google Scholar 

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. https://doi.org/10.1186/s13643-016-0384-4.

Article  PubMed  PubMed Central  Google Scholar 

Wang K, Wang C, Xi L, Zhang Y, Ouyang Y, Lou H, et al. A randomized controlled trial to assess adherence to allergic rhinitis treatment following a daily short message service (SMS) via the mobile phone. Int Arch Allergy Immunol. 2014;163(1):51–8. https://doi.org/10.1159/000356317.

Article  PubMed  Google Scholar 

Akin BG, Kar I, Aydin O. Evaluation of adherence and attitudes of patients with allergic rhinitis to nasal steroid treatment. Asian Pac J Allergy Immunol. 2024;((Akin, Aydin) Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine). Located at: Embase; 643187639. https://doi.org/10.12932/AP-090523-1607

Bollinger ME, Diette GB, Chang CL, Stephenson JJ, Sajjan SG, Fan T, et al. Patient characteristics and prescription fill patterns for allergic rhinitis medications, with a focus on montelukast, in a commercially insured population. Clin Ther. 2010;32(6):1093–102. https://doi.org/10.1016/j.clinthera.2010.06.003.

Article  PubMed  Google Scholar 

Bousquet J, Devillier P, Arnavielhe S, Bedbrook A, Alexis-Alexandre G, van Eerd M, et al. Treatment of allergic rhinitis using mobile technology with real-world data: the MASK observational pilot study. Allergy. 2018;73(9):1763–74. https://doi.org/10.1111/all.13406.

Article  CAS  PubMed  Google Scholar 

Gani F, Pozzi E, Crivellaro MA, Senna G, Landi M, Lombardi C, et al. The role of patient training in the management of seasonal rhinitis and asthma: clinical implications. Allergy. 2001;56(1):65–8. https://doi.org/10.1034/j.1398-9995.2001.00794.x.

Article  CAS  PubMed  Google Scholar 

Hankin CS, Cox L, Lang D, Bronstone A, Wang Z, Lepore MS, et al. Medical costs and adherence in patients receiving aqueous versus pressurized aerosol formulations of intranasal corticosteroids. Allergy Asthma Proc. 2012;33(3):258–64. https://doi.org/10.2500/aap.2012.33.3565.

Article  PubMed  Google Scholar 

Larenas-Linnemann DES, Domthong P, Di Francesco RC, González-Pérez R, Verma M. General practitioner and patient perspectives on intranasal corticosteroids for allergic rhinitis: treatment duration and obstacles to adherence, findings from a recent survey. World Allergy Organ J. 2024;17(7):100925. https://doi.org/10.1016/j.waojou.2024.100925.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee BW, Lee CS, Lim ER, Tham AC. Intranasal steroid use and satisfaction in allergic rhinitis: a cross-sectional study from an Asian perspective. ORL J Otorhinolaryngol Relat Spec. 2022;84(1):55–61. https://doi.org/10.1159/000516040.

Article  PubMed  Google Scholar 

Loh CY, Chao SS, Chan YH, Wang DY. A clinical survey on compliance in the treatment of rhinitis using nasal steroids. Allergy. 2004;59(11):1168–72. https://doi.org/10.1111/j.1398-9995.2004.00554.x.

Article  CAS  PubMed  Google Scholar 

Singh MPK, Krishnan EK, Lazim MN, Yaacob NM, Abdullah B. Medication adherence to intranasal corticosteroids in allergic rhinitis patients with comorbid medical conditions. Pharmaceutics. 2022;14(11):2459. https://doi.org/10.3390/pharmaceutics14112459.

Article  CAS  Google Scholar 

Szilasi M, Gálffy G, Fónay K, Márk Z, Rónai Z, Szalai Z, et al. A survey of the burden of allergic rhinitis in Hungary from a specialist’s perspective. Multidiscip Respir Med. 2012;7(1):49. https://doi.org/10.1186/2049-6958-7-49.

Article  PubMed  PubMed Central  Google Scholar 

Stirratt MJ, Dunbar-Jacob J, Crane HM, Simoni JM, Czajkowski S, Hilliard ME, et al. Self-report measures of medication adherence behavior: recommendations on optimal use. Transl Behav Med. 2015;5(4):470–82. https://doi.org/10.1007/s13142-015-0315-2.

Article  PubMed  PubMed Central  Google Scholar 

De Las Cuevas C, Peñate W. Psychometric properties of the eight-item Morisky Medication Adherence Scale (MMAS-8) in a psychiatric outpatient setting. Int J Clin Health Psychol. 2015;15(2):121–9. https://doi.org/10.1016/j.ijchp.2014.11.003.

Article  PubMed  Google Scholar 

Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119(23):3028–35. https://doi.org/10.1161/CIRCULATIONAHA.108.768986.

Article  PubMed  Google Scholar 

Frieden TR, Garg R, Banigbe B, Choudhury S, Ogbureke N, Duguma D, et al. Unlocking health equity by eliminating copayments for essential antihypertensive medications. EClinicalMedicine. 2025. https://doi.org/10.1016/j.eclinm.2025.103094.

Article  PubMed  PubMed Central  Google Scholar 

Lee SE, Brown WC, Gelpi MW, Kimple AJ, Senior BA, Zanation AM, et al. Understood? Evaluating the readability and understandability of intranasal corticosteroid delivery instructions. Int Forum Allergy Rhinol. 2020;10(6):773–8. https://doi.org/10.1002/alr.22550.

Article  PubMed  PubMed Central  Google Scholar 

Sheeran N, Jones L, Pines R, Jin B, Pamoso A, Eigeland J, et al. How culture influences patient preferences for patient-centered care with their doctors. J Commun Healthc. 2023;16(2):186–96. https://doi.org/10.1080/17538068.2022.2095098.

Article  PubMed  Google Scholar 

Phinyo P, Wongsa C, Sompornrattanaphan M, Thongngarm T. As-needed versus regular intranasal corticosteroid for allergic rhinitis: a systematic review and meta-analysis. Asian Pac J Allergy Immunol. 2022;40(3):195–204. https://doi.org/10.12932/AP-091121-1269.

Article  CAS  PubMed  Google Scholar 

Hugtenburg JG, Timmers L, Elders PJ, Vervloet M, van Dijk L. Definitions, variants, and causes of nonadherence with medication: a challenge for tailored interventions. Patient Prefer Adherence. 2013;7:675–82. https://doi.org/10.2147/PPA.S29549.

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