Chamorro Á et al (2016) Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol 15(8):869–881

Article  CAS  PubMed  Google Scholar 

Ning L et al (2024) AMPA receptors in Alzheimer disease: pathological changes and potential therapeutic targets. J Neuropathol Exp Neurol 83(11):895–906

Article  CAS  PubMed  Google Scholar 

Salpietro V et al (2019) AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. Nat Commun 10(1):3094

Article  PubMed  PubMed Central  Google Scholar 

Wang Y et al (2010) Regulation of AMPA receptors in spinal nociception. Mol Pain 6:5

Article  PubMed  PubMed Central  Google Scholar 

Hrickova M, Ruda-Kucerova J (2025) Do AMPA/kainate antagonists possess potential in the treatment of addiction? Evidence from animal behavioural studies. Prog Neuropsychopharmacol Biol Psychiatry 138:111355

Article  CAS  PubMed  Google Scholar 

Langan YM et al (2003) Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia 44(1):46–53

Article  CAS  PubMed  Google Scholar 

Pulkrabkova L et al (2023) Neurotoxicity evoked by organophosphates and available countermeasures. Arch Toxicol 97(1):39–72

Article  CAS  PubMed  Google Scholar 

Glasgow NG et al (2017) Memantine and ketamine differentially alter NMDA receptor desensitization. J Neurosci 37(40):9686–9704

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blanpied TA, Clarke RJ, Johnson JW (2005) Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci 25(13):3312–3322

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganor Y et al (2003) Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J Immunol 170(8):4362–4372

Article  CAS  PubMed  Google Scholar 

Dickman KG et al (2004) Ionotropic glutamate receptors in lungs and airways: molecular basis for glutamate toxicity. Am J Respir Cell Mol Biol 30(2):139–144

Article  CAS  PubMed  Google Scholar 

Boldyrev AA et al (2004) Rodent lymphocytes express functionally active glutamate receptors. Biochem Biophys Res Commun 324(1):133–139

Article  CAS  PubMed  Google Scholar 

Miglio G, Varsaldi F, Lombardi G (2005) Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation. Biochem Biophys Res Commun 338(4):1875–1883

Article  CAS  PubMed  Google Scholar 

Biermann T et al (2007) Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal. J Neural Transm (Vienna) 114(8):1081–1084

Article  CAS  PubMed  Google Scholar 

Sarchielli P et al (2007) Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients. J Neuroimmunol 188(1–2):146–158

Article  CAS  PubMed  Google Scholar 

Kvaratskhelia E et al (2009) N-methyl-D-aspartate and sigma-ligands change the production of interleukins 8 and 10 in lymphocytes through modulation of the NMDA glutamate receptor. NeuroImmunoModulation 16(3):201–207

Article  CAS  PubMed  Google Scholar 

Sedaghati M et al (2010) Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies. Eur J Pharmacol 633(1–3):50–54

Article  CAS  PubMed  Google Scholar 

Mashkina AP et al (2010) NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo. Cell Mol Neurobiol 30(6):901–907

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roozafzoon R et al (2010) Expression of NMDA receptor subunits in human peripheral blood lymphocytes in opioid addiction. Eur J Pharmacol 638(1–3):29–32

Article  CAS  PubMed  Google Scholar 

Affaticati P et al (2011) Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells. Cell Death Differ 18(1):99–108

Article  CAS  PubMed  Google Scholar 

Kahlfuß S et al (2014) Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells. Mol Cell Biol 34(5):820–831

Article  PubMed  Google Scholar 

Bhandage AK et al (2017) AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women. J Neuroimmunol 305:51–58

Article  CAS  PubMed  Google Scholar 

Orihara K et al (2018) Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans. Immunology 153(3):368–379

Article  CAS  PubMed  Google Scholar 

Sadat-Shirazi MS et al (2019) NMDA receptors of blood lymphocytes anticipate cognitive performance variations in healthy volunteers. Physiol Behav 201:53–58

Article  CAS  PubMed  Google Scholar 

Levite M et al (2020) Dual-targeted autoimmune sword in fatal epilepsy: patient’s glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce reactive oxygen species (ROS) in, and kill both human neural cells and T cells. J Autoimmun 112:102462

Article  CAS  PubMed  Google Scholar 

Alim MA et al (2021) Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells. Cell Mol Immunol 18(10):2383–2392

Article  CAS  PubMed  Google Scholar 

Jeon HJ et al (2023) N-methyl-D-aspartate receptors induce M1 polarization of macrophages: feasibility of targeted imaging in inflammatory response in vivo. Cell Biosci 13(1):69

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torres VO et al (2025) B cells upregulate NMDARs, respond to extracellular glutamate, and express mature BDNF to protect the brain from ischemic injury. Neurobiol Dis 207:106819

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayashi T et al (1999) The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature 397(6714):72–76

Article  CAS  PubMed  Google Scholar 

Robert V et al (2011) Calcium signalling in T-lymphocytes. Biochimie 93(12):2087–2094

Article  CAS  PubMed  Google Scholar 

Sjöstedt E et al (2020) An atlas of the protein-coding genes in the human, pig, and mouse brain. Science. https://doi.org/10.1126/science.aay5947

Article