SCI Abstract

search
+
Incidence, mortality, and risk factors of bladder, kidney, prostate and testicular cancers in China and comparisons with the United States, the United Kingdom, Japan, and the Republic of Korea: an up-to-date overview based on the Global Burden of Disease 2021
Incidence, mortality, and risk factors of bladder, kidney, prostate and testicular cancers in China and comparisons with the United States, the United Kingdom, Japan, and the Republic of Korea: an up-to-date overview based on the Global Burden of Disease 2021
The burden of genitourinary cancers has significantly changed in China over the recent decades. This study aims to identif...
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy
The tumor microenvironment (TME) is widely acknowledged as a pivotal regulator of cancer progression. However, the dualist...
Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation
Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation
Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failur...
CD47 antibody-armed oncolytic adenovirus promotes chimeric antigen receptor macrophage phagocytosis and antitumor immunity
CD47 antibody-armed oncolytic adenovirus promotes chimeric antigen receptor macrophage phagocytosis and antitumor immunity
Chimeric antigen receptor (CAR)-T cell therapy has shown success in hematologic malignancies but has encountered challenge...
Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia
Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia
A tyrosine kinase inhibitor (TKI) such as Imatinib (IM) is the preferred treatment for Chronic Myeloid Leukemia (CML). How...
Radiation-induced exosomal miR-21 enhances tumor proliferation and invasiveness in breast cancer: implications for poor prognosis in radiotherapy patients
Radiation-induced exosomal miR-21 enhances tumor proliferation and invasiveness in breast cancer: implications for poor prognosis in radiotherapy patients
Radiotherapy is widely used as an effective non-surgical strategy to control malignant tumors. However, recurrence is one ...
Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses
Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses
Tumor-associated macrophages (TAMs) are immunosuppressive cells within the tumor microenvironment (TME) that hinder anti-t...
Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial
Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial
Due to the lack of effective treatment options, the prognosis of patients with relapsed/refractory acute myeloid leukemia ...
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Pyroptosis, an inflammatory programmed cell death, distinguishes itself from apoptosis and necroptosis and has drawn incre...
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Pseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation of mucus in the peritoneal...
A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
Differentiating between pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) is crucial for the appropriat...
Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation
Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation
Cyclic-dependent kinase (CDK) 4/6 kinases, as the critical drivers of the cell cycle, are involved in the tumor progressio...
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit M...
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, ...
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posin...
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Dendritic cells (DCs) serve as a pivotal link connecting innate and adaptive immunity by processing tumor-derived antigens...
The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
Mutation in KRAS protooncogene represents one of the most common genetic alterations in NSCLC and has posed a great therap...
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Recurrence is one of the main causes of treatment failure in early-stage non-small cell lung cancer (NSCLC). However, ther...
CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is essentially an a...
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Targeted therapy with Bruton tyrosine kinase (BTK) inhibitors have revolutionized the treatment of patients with various B...
New insight into circRNAs: characterization, strategies, and biomedical applications
New insight into circRNAs: characterization, strategies, and biomedical applications
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs are derived from exonic or int...
Targeting CD22 for B-cell hematologic malignancies
Targeting CD22 for B-cell hematologic malignancies
CD19-targeted chimeric receptor antigen (CAR)-T cell therapy has shown remarkable clinical efficacy in the treatment of re...
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deleti...
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfuncti...
Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identification of a novel NPM1 mutation in acute myeloid leukemia
Identification of a novel NPM1 mutation in acute myeloid leukemia
Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It i...
Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness ...
Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent studies have highlighted a signif...
Focal adhesion kinase: from biological functions to therapeutic strategies
Focal adhesion kinase: from biological functions to therapeutic strategies
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functio...
The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer
The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer
The pattern recognition receptor long pentraxin-3 (PTX3) plays conflicting roles in cancer by acting as an oncosuppressor ...
Load More
format_indent_increase