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Mast cell sarcoma with KIT p.D816V mutation and concurrent systemic mastocytosis
Mast cell sarcoma with KIT p.D816V mutation and concurrent systemic mastocytosis
Mast cell sarcoma (MCS) is an extremely rare and aggressive form of mastocytosis characterized by highly atypical mast cel...
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid...
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy
Targeted immunotherapy is a promising approach in treating high-risk and refractory/relapsed lymphoid malignancies. Althou...
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, with most cases harboring ALK gene rearra...
BRAF V600E mutation and high expression of PD-L1 in Rosai-Dorfman disease: case report and review of the literature
BRAF V600E mutation and high expression of PD-L1 in Rosai-Dorfman disease: case report and review of the literature
BRAF V600E mutations are frequently found in histiocytic/dendritic cell neoplasms such as Erdheim-Chester disease (ECD) an...
Perifollicular concentric granulomas: A clue to IgG4-related lymphadenopathy
Perifollicular concentric granulomas: A clue to IgG4-related lymphadenopathy
A 69-year-old with well-controlled HIV was evaluated for persistent cough, in the context of years of fatigue and...
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Leprosy, caused by Mycobacterium leprae (M. leprae), primarily manifests with cutaneous and peripheral nerve invo...
Navigating diagnostic dilemmas: a rare presentation of extramedullary T-lymphoblastic leukemia/lymphoma with chronic myeloid leukemia
Navigating diagnostic dilemmas: a rare presentation of extramedullary T-lymphoblastic leukemia/lymphoma with chronic myeloid leukemia
Chronic myeloid leukemia (CML) typically presents in the chronic phase. The blast crisis phase in CML predominantly compri...
Paraneoplastic glomerulonephritis and kidney infiltration by mantle cell lymphoma: A diagnostic challenge
Paraneoplastic glomerulonephritis and kidney infiltration by mantle cell lymphoma: A diagnostic challenge
Mantle cell lymphoma (MCL) is a rare and aggressive type of lymphoma that can affect the kidneys. The disease can lead to ...
Primary anaplastic large cell lymphoma arising from central nervous system
Primary anaplastic large cell lymphoma arising from central nervous system
A 22-year-old man presented at the emergency department with progressive headache, vomiting and horizontal diplopia over 2...
Anaplastic large cell lymphoma presenting as a mass in the uterine cervix: a case report
Anaplastic large cell lymphoma presenting as a mass in the uterine cervix: a case report
T-cell lymphoma is an extremely rare form of malignancy in the female genital tract. Most of the reported cases of lymphom...
Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements
Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements
Cutaneous T-cell lymphomas (CTCL) are a clinically and molecularly heterogeneous class of lymphomas of the skin-homing T c...
A rare case of fluid overload-associated large B-cell lymphoma and antigen loss at relapse
A rare case of fluid overload-associated large B-cell lymphoma and antigen loss at relapse
Fluid overload-associated large B-cell lymphoma (FO-LBCL) is a new addition to the list of large B-cell lymphomas in the 5...
Oral follicular lymphoma: a clinicopathologic and molecular study
Oral follicular lymphoma: a clinicopathologic and molecular study
Follicular lymphoma is a hematolymphoid neoplasm that originates from germinal center B cells. It is made up of a combinat...
Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease
Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease
Lymphadenopathy is a common finding in patients with IgG4-related disease (IgG4-RD) and often associated with increased Ig...
B-lymphoblastic leukemia with transient spontaneous remission in the setting of severe group A streptococcus infection
B-lymphoblastic leukemia with transient spontaneous remission in the setting of severe group A streptococcus infection
Spontaneous remission of B-lymphoblastic leukemia (B-ALL) in the setting of viral and bacterial infections has been report...
Indolent B-cell lymphoma with t(14;19) investigated from a molecular perspective
Indolent B-cell lymphoma with t(14;19) investigated from a molecular perspective
T(14;19) is an unusual but distinct genomic alteration reported in low-grade B-cell lymphomas. This structural rearrangeme...
Lupus erythematosus cells in a bone marrow aspirate
Lupus erythematosus cells in a bone marrow aspirate
A teenage girl presented with fevers of unknown origin and pancytopenia. Complete blood count showed anemia (hemoglobin, 9...
Chronic myeloid leukaemia (CML) presenting in B-lymphoblastic crisis: a diagnostic challenge
Chronic myeloid leukaemia (CML) presenting in B-lymphoblastic crisis: a diagnostic challenge
We report the case of a 75-year-old female presented with lethargy, Hb 93 g/L, WBC 64 x 109/L, platelet 110 x 109/L. Blood...
The role of IgG4-positive plasma cell population in classic Hodgkin lymphoma
The role of IgG4-positive plasma cell population in classic Hodgkin lymphoma
The effect of IgG4, which constitutes the least of the IgG subclasses, on the pathogenesis and prognosis of lymphoma or so...