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Nucleolated cells in extranodal marginal zone lymphoma: a case report and discussion of circulating lymphoma cells with prominent nucleoli
Nucleolated cells in extranodal marginal zone lymphoma: a case report and discussion of circulating lymphoma cells with prominent nucleoli
Various types of lymphoma/leukemia can present with leukemic involvement by neoplastic cells with prominent nucleoli. Pati...
Demystifying the evaluation of a “dry tap”
Demystifying the evaluation of a “dry tap”
“Dry tap” refers to the failed aspiration of bone marrow hematopoietic elements. Faulty technique is frequentl...
Day + 100 bone marrow megakaryocyte count predicts transplant outcome in patients with high-risk myelodysplastic syndrome and acute leukemia
Day + 100 bone marrow megakaryocyte count predicts transplant outcome in patients with high-risk myelodysplastic syndrome and acute leukemia
Megakaryocytes (MKs), the precursor cells of platelets, have essential roles in a variety of pathophysiological processes ...
Mantle cell lymphoma with a prominent intrasinusoidal pattern of bone marrow involvement and circulating “prolymphocytoid” cells: an unusual pathological presentation posing diagnostic pitfalls
Mantle cell lymphoma with a prominent intrasinusoidal pattern of bone marrow involvement and circulating “prolymphocytoid” cells: an unusual pathological presentation posing diagnostic pitfalls
Ethical approval All procedures performed in studies involv...
The t(18;22)/:: translocation defines a unique CLL subtype: association with early treatment initiation
The t(18;22)/:: translocation defines a unique CLL subtype: association with early treatment initiation
The most prevalent BCL2 fusion in B-cell lymphoma involves the IGH gene, attributable to the t(14;18)(q32;q21) translocati...
Variant allele fraction or copy-neutral loss of heterozygosity? A comparison of testing platforms in the classification of myeloid neoplasia
Variant allele fraction or copy-neutral loss of heterozygosity? A comparison of testing platforms in the classification of myeloid neoplasia
Myelodysplastic syndrome (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN) classification requires integrati...
Reed-Sternberg cell-like morphologic variant of B-lymphoblastic leukemia
Reed-Sternberg cell-like morphologic variant of B-lymphoblastic leukemia
Ethical approval This article does not contain any studies ...
A case of acid sphingomyelinase deficiency type B with prominent histiocytes with engulfed nucleated cells and compound heterozygosity
A case of acid sphingomyelinase deficiency type B with prominent histiocytes with engulfed nucleated cells and compound heterozygosity
Acid sphingomyelinase deficiency type B (ASMD-B), also known as Niemann-Pick type B (NPB), is caused by inherited mutation...
A rare case of B-cell acute lymphoblastic leukemia with translocation (14;14)(q11.2;q32) involving and with review of the literature
A rare case of B-cell acute lymphoblastic leukemia with translocation (14;14)(q11.2;q32) involving and with review of the literature
Translocation (14;14)(q11;q32) with immunoglobulin heavy chain (IGH) (14q32) and CCAAT enhancer-binding protein (CEBPE) (1...
Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology
Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology
Castleman disease is a clinicopathological entity that shares features with hematological, rheumatological, and infectious...
CD5-positive B-cell acute lymphoblastic leukemia/lymphoma with mimicking aggressive mature B-cell lymphoma: a case report of a newly described entity and potential diagnostic pitfall
CD5-positive B-cell acute lymphoblastic leukemia/lymphoma with mimicking aggressive mature B-cell lymphoma: a case report of a newly described entity and potential diagnostic pitfall
Here, we present a challenging diagnostic case of a B-cell acute lymphoblastic leukemia (B-ALL) presenting as a rare extra...
Primary myelofibrosis with concurrent and atypical mutations
Primary myelofibrosis with concurrent and atypical mutations
Distinct bone marrow morphology is considered the primary basis for the diagnosis of BCR::ABL1-negative myeloprol...
Evaluation of CD200 marker variations and its correlation with clinicopathological features of chronic lymphocytic leukemia patients: a case–control study
Evaluation of CD200 marker variations and its correlation with clinicopathological features of chronic lymphocytic leukemia patients: a case–control study
Given its strong correlation with disease progression and risk stratification, CD200 has emerged as a pivotal biomarker in...
A novel homozygous frameshift mutation (p.Lys365Glnfs*69) in a family with hereditary factor XII deficiency: a case report
A novel homozygous frameshift mutation (p.Lys365Glnfs*69) in a family with hereditary factor XII deficiency: a case report
Factor XII (FXII) deficiency is a rare autosomal recessive disorder characterized by prolonged activated partial thrombopl...
EGLN1-positive familial erythrocytosis: a rare variant with an unusually aggressive clinical course
EGLN1-positive familial erythrocytosis: a rare variant with an unusually aggressive clinical course
Familial erythrocytosis type 3 (ECYT3) is a rare condition caused by loss of function germline mutations in the prolyl hyd...
Unicentric Castleman disease following POEMS syndrome remission
Unicentric Castleman disease following POEMS syndrome remission
POEMS syndrome is a rare paraneoplastic disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal...
Granulomas in bone marrow: is it always tuberculosis?
Granulomas in bone marrow: is it always tuberculosis?
Granulomas in a bone marrow biopsy are like gold dust. Numerous studies have reported that the incidence of granu...
Masked by eosinophils: a cryptic presentation of pediatric B-ALL with IGH rearrangement
Masked by eosinophils: a cryptic presentation of pediatric B-ALL with IGH rearrangement
Hypereosinophilia is uncommon in the pediatric population and may be associated with either primary or secondary condition...
Discovery of a germline deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature
Discovery of a germline deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature
Somatic IKZF1 alterations are common in B-lymphoblastic leukemia (B-ALL) and are generally associated with poor outcomes. ...
Plasmablastic plasmacytoma followed by a plasmacytic plasma cell myeloma: insights into discordant extramedullary transformation—a case report and literature review
Plasmablastic plasmacytoma followed by a plasmacytic plasma cell myeloma: insights into discordant extramedullary transformation—a case report and literature review
Plasma cell neoplasms encompass a spectrum of disorders characterized by the clonal proliferation of plasma cells. Plasmab...
Mast cell sarcoma with KIT p.D816V mutation and concurrent systemic mastocytosis
Mast cell sarcoma with KIT p.D816V mutation and concurrent systemic mastocytosis
Mast cell sarcoma (MCS) is an extremely rare and aggressive form of mastocytosis characterized by highly atypical mast cel...
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid...
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy
Targeted immunotherapy is a promising approach in treating high-risk and refractory/relapsed lymphoid malignancies. Althou...
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, with most cases harboring ALK gene rearra...
BRAF V600E mutation and high expression of PD-L1 in Rosai-Dorfman disease: case report and review of the literature
BRAF V600E mutation and high expression of PD-L1 in Rosai-Dorfman disease: case report and review of the literature
BRAF V600E mutations are frequently found in histiocytic/dendritic cell neoplasms such as Erdheim-Chester disease (ECD) an...
Extra-adrenal myelolipoma involved by plasma cell neoplasm: homing of neoplastic plasma cells to a site of ectopic hematopoiesis
Extra-adrenal myelolipoma involved by plasma cell neoplasm: homing of neoplastic plasma cells to a site of ectopic hematopoiesis
Ethical approval All procedures performed in studies involv...
Macrothrombocytopenia and granulopoieitic Döhle body-like inclusions in a MYH9-related disorder
Macrothrombocytopenia and granulopoieitic Döhle body-like inclusions in a MYH9-related disorder
Ethical approval All procedures performed in studies involv...
Perifollicular concentric granulomas: A clue to IgG4-related lymphadenopathy
Perifollicular concentric granulomas: A clue to IgG4-related lymphadenopathy
A 69-year-old with well-controlled HIV was evaluated for persistent cough, in the context of years of fatigue and...
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Leprosy, caused by Mycobacterium leprae (M. leprae), primarily manifests with cutaneous and peripheral nerve invo...
Misdiagnosis of Hodgkin disease as histiocytosis is associated with adverse consequences
Misdiagnosis of Hodgkin disease as histiocytosis is associated with adverse consequences
Conflict of interest The authors declare no competing inter...
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