Guan JL, Shalloway D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature. 1992;358:690–2.
Article CAS PubMed Google Scholar
Nader GPF, Ezratty EJ, Gundersen GG. FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly. Nat Cell Biol. 2016;18:491–503.
Article CAS PubMed Google Scholar
Fan T, Chen J, Zhang L, Gao P, Hui Y, Xu P, et al. Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway. Mol Cancer. 2016;15:23.
Article PubMed PubMed Central Google Scholar
Balsas P, Palomero J, Eguileor Á, Rodríguez ML, Vegliante MC, Planas-Rigol E, et al. SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma. Blood. 2017;130:501–13.
Article CAS PubMed Google Scholar
Skinner HD, Giri U, Yang L, Woo SH, Story MD, Pickering CR, et al. Proteomic profiling identifies PTK2/FAK as a driver of radioresistance in HPV-negative head and neck cancer. Clin Cancer Res. 2016;22:4643–50.
Article CAS PubMed PubMed Central Google Scholar
Yoon H, Dehart JP, Murphy JM, Lim S-TS. Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights. J Histochem Cytochem. 2015;63:114–28.
Chuang HH, Zhen YY, Tsai YC, Chuang CH, Hsiao M, Huang MS, et al. FAK in cancer: from mechanisms to therapeutic strategies. Int J Mol Sci. 2022;23:1726.
Article CAS PubMed PubMed Central Google Scholar
Rigiracciolo DC, Cirillo F, Talia M, Muglia L, Gutkind JS, Maggiolini M, et al. Focal adhesion kinase fine tunes multifaced signals toward breast cancer progression. Cancers. 2021;13:645.
Article CAS PubMed PubMed Central Google Scholar
Golubovskaya VM. Targeting FAK in human cancer: from finding to first clinical trials. Front Biosci. 2014;19:687–706.
Tremblay L, Hauck W, Aprikian AG, Begin LR, Chapdelaine A, Chevalier S. Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer. 1996;68:164–71.
Article CAS PubMed Google Scholar
Ossovskaya V, Lim ST, Ota N, Schlaepfer DD, Ilic D. FAK nuclear export signal sequences. FEBS Lett. 2008;582:2402–6.
Article CAS PubMed PubMed Central Google Scholar
Zhou J, Yi Q, Tang L. The roles of nuclear focal adhesion kinase (FAK) on cancer: a focused review. J Exp Clin Cancer Res. 2019;38:250.
Article PubMed PubMed Central Google Scholar
Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008;29:9–22.
Article CAS PubMed PubMed Central Google Scholar
Constanzo JD, Tang K-J, Rindhe S, Melegari M, Liu H, Tang X, et al. PIAS1-FAK interaction promotes the survival and progression of non-small cell lung cancer. Neoplasia. 2016;18:282–93.
Article CAS PubMed PubMed Central Google Scholar
Tai H-C, Chang A-C, Yu H-J, Huang C-Y, Tsai Y-C, Lai Y-W, et al. Osteoblast-derived WNT-induced secreted protein 1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126. Oncotarget. 2014;5:7589–98.
Article PubMed PubMed Central Google Scholar
Serrels B, McGivern N, Canel M, Byron A, Johnson SC, McSorley HJ, et al. IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks. Sci Signal. 2017;10: eaan8355.
Article PubMed PubMed Central Google Scholar
Lim S-T, Miller NLG, Chen XL, Tancioni I, Walsh CT, Lawson C, et al. Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol. 2012;197:907–19.
Article CAS PubMed PubMed Central Google Scholar
Frame MC, Patel H, Serrels B, Lietha D, Eck MJ. The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol. 2010;11:802–14.
Article CAS PubMed Google Scholar
Cooper J, Giancotti FG. Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance. Cancer Cell. 2019;35:347–67.
Article CAS PubMed PubMed Central Google Scholar
Sun X, Meng L, Qiao W, Yang R, Gao Q, Peng Y, et al. Vascular endothelial growth factor A/Vascular endothelial growth factor receptor 2 axis promotes human dental pulp stem cell migration via the FAK/PI3K/Akt and p38 MAPK signalling pathways. Int Endod J. 2019;52:1691–703.
Article CAS PubMed Google Scholar
Shen T, Guo Q. EGFR signaling pathway occupies an important position in cancer-related downstream signaling pathways of Pyk2. Cell Biol Int. 2019;44:2–13.
Article PubMed PubMed Central Google Scholar
Rigiracciolo DC, Santolla MF, Lappano R, Vivacqua A, Cirillo F, Galli GR, et al. Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells. J Exp Clin Cancer Res. 2019;38:58.
Article PubMed PubMed Central Google Scholar
Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, et al. Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proc Natl Acad Sci USA. 2014;111:E3177–86.
Article PubMed PubMed Central Google Scholar
Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, et al. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol. 2008;180:187–203.
Article CAS PubMed PubMed Central Google Scholar
Mousson A, Sick E, Carl P, Dujardin D, De Mey J, Rondé P. Targeting focal adhesion kinase using inhibitors of protein–protein interactions. Cancers. 2018;10:278.
Article PubMed PubMed Central Google Scholar
Rashid M, Belmont J, Carpenter D, Turner CE, Olson EC. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017;144:4002–14.
CAS PubMed PubMed Central Google Scholar
Baumann K. Cell adhesion: FAK or talin: who goes first? Nat Rev Mol Cell Biol. 2012;13:138.
Brami-Cherrier K, Gervasi N, Arsenieva D, Walkiewicz K, Boutterin MC, Ortega A, et al. FAK dimerization controls its kinase-dependent functions at focal adhesions. Embo J. 2014;33:356–70.
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT. The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell. 2002;13:2147–56.
Article CAS PubMed PubMed Central Google Scholar
Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol. 1994;14:1680–8.
CAS PubMed PubMed Central Google Scholar
Parsons JT. Focal adhesion kinase: the first ten years. J Cell Sci. 2003;116:1409–16.
Article CAS PubMed Google Scholar
Calalb MB, Polte TR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol. 1995;15:954–63.
Article CAS PubMed PubMed Central Google Scholar
Lim Y, Park H, Jeon J, Han I, Kim J, Jho EH, et al. Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407. J Biol Chem. 2007;282:10398–404.
Article CAS PubMed Google Scholar
Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994;372:786–91.
Article CAS PubMed Google Scholar
Mitra SK, Mikolon D, Molina JE, Hsia DA, Hanson DA, Chi A, et al. Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene. 2006;25:5969–84.
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