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SCI Abstract
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Effect of co-administration of lactobacilli S-layer proteins on immune response against S-layer proteins from pathogenic Clostridioides difficile
Introduction. Vaccine adjuvants are essential for enhancing and directing specific immune responses. S-layer proteins (SLP...
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Overview of US public health laboratory leadership development programmes and implementation opportunities
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Parasitology of the twenty-first century: are we moving in the right direction?
For thousands of years, parasitic infections have represented a constant challenge to human health. Despite constant progr...
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Phenotypic and phylogenetic analyses of Listeria monocytogenes strains reveal enhanced bile tolerance in clinical isolates
Introduction. Molecular epidemiological and phenotypic analyses of Listeria monocytogenes strains can inform our understan...
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Enhancing mortality prediction in AIDS and disseminated Talaromyces marneffei: the impact of novel inflammatory markers in a nomogram
Introduction. Talaromyces marneffei (TM) is a common opportunistic infection among patients with AIDS, characterized by ra...
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Changes in the gut microbiota in mice exposed to chronic intermittent hypoxia
Introduction. Obstructive sleep apnoea syndrome (OSAS) is characterized by chronic intermittent hypoxia (CIH), which contr...
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Clinical characteristics and outcomes of viral respiratory infections in allogeneic haematopoietic stem cell transplantation recipients: a single-centre experience
Introduction. Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a treatment option for haematological mal...
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Effects of novel organoantimony compounds on the fungal pathogen Cryptococcus neoformans
Introduction. Cryptococcus neoformans is an opportunistic fungal pathogen that causes pulmonary cryptococcosis, or an acut...
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Shaping the future of Leptospira serotyping
Leptospirosis is a re-emerging zoonosis caused by a diverse range of pathogenic Leptospira, which are divided into species...
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Role and mechanism of hexyl-aminolevulinate ethosome-mediated antimicrobial photodynamic therapy in reversing fluconazole resistance in Nakaseomyces glabrata (Candida glabrata)
Introduction. Azoles are extensively employed as clinical antifungal agents; however, their long-term and widespread appli...
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Combination effect of meropenem and antifungals against Escherichia coli-Candida albicans dual-species biofilms in vitro and in vivo using a silkworm model
Introduction. Biofilms are a primary form of device-associated infections and typically exhibit high tolerance to antimicr...
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Correlation in the change of gut microbiota with clinical periodontal parameters in grade C periodontitis patients after non-surgical periodontal therapy
Introduction. Intestinal dysbiosis is associated with systemic health, and approaches targeting the microbiome can influen...
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Diagnosis of infectious diseases
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A testing time for gradient strips: an evaluation of ETEST for the antimicrobial susceptibility testing of Neisseria gonorrhoeae
Introduction. Antimicrobial susceptibility testing (AST) of Neisseria gonorrhoeae isolates is recommended in the UK to ens...
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Reduction of resources with mRNA host-response whole blood testing on patients presenting to the emergency department with suspected infections: a retrospective analysis of 30 cases
Introduction. The TriVerity™ test (Inflammatix Inc.) uses the patient’s mRNA expression patterns from whole blood to provi...
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Unravelling three-way interactions between Clostridioides difficile, microbiota and the host
Clostridioides difficile infection is a global issue, representing a huge financial burden on healthcare systems worldwide...
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Induction of lipid A modification genes in Pseudomonas aeruginosa cells tolerant to a commercially available contact lens disinfection solution
Introduction. Pseudomonas aeruginosa has a high propensity to develop drug resistance and is a leading cause of bacterial ...
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Surveillance of genomic diversity and antimicrobial resistance in enterotoxigenic Escherichia coli in England, 2015–2023
Introduction. Enterotoxigenic Escherichia coli (ETEC) are one of the leading causes of gastrointestinal infections globall...
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A nanoluciferase-tagged Schmallenberg virus (SBV): an efficient tool for measuring and tracking viral infection dynamics
Introduction. Schmallenberg virus (SBV) is an arthropod-borne virus and belongs to the Simbu serogroup within the family P...
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The lingering legacy of one letter in antimicrobial susceptibility testing
For decades, the ‘Intermediate’ (I) category in antimicrobial susceptibility testing was frequently misinterpreted as indi...
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Geographical and temporal variations of serogroups and clonal types of Neisseria meningitidis involved in culture-confirmed invasive meningococcal disease in Canada, 2015–2023
Introduction. Invasive meningococcal disease (IMD) is a nationally notifiable illness in Canada due to its potential sever...
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Evaluation of whole-genome sequencing protocols for detection of antimicrobial resistance, virulence factors and mobile genetic elements in antimicrobial-resistant bacteria
Introduction. Antimicrobial resistance (AMR) poses a critical threat to global health, underscoring the need for rapid and...
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Impact of cyclosporine A on the progression of ocular surface diseases: treatment efficacy and potential complications
Introduction. Eye diseases are widespread all over the world and, if left untreated, can lead to blindness. Hypothesis. Th...
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Influence of menstrual cycle and oral contraception on taxonomic composition and gas production in the gut microbiome
Introduction. Oral contraceptives (OCs) are widely used for birth control and offer benefits such as menstrual cycle regul...
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Antimicrobial and antiparasitic potential of lupeol: antifungal effect on the Candida parapsilosis species complex and nematicidal activity against Caenorhabditis elegans
Introduction. There is growing concern about infections caused by non-albicans Candida species, including species of the C...
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Sepsis in silico: definition, development and application of an electronic phenotype for sepsis
Repurposing electronic health record (EHR) or electronic medical record (EMR) data holds significant promise for evidence-...
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Comprehensive toolkit integrating lifestyle and clinical questionnaires with gut microbiota profiling via rectal swabs: application in intensive care cirrhotic patients
Introduction. The study of gut microbiota is now an essential dimension in many clinical studies. For instance, microbiota...
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Epidemiology and management of infections in critically ill neonates: findings from a cohort study in a Brazilian neonatal intensive care unit
Introduction. Healthcare-associated infections (HAIs) are the leading cause of preventable death in neonatal intensive car...
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Genotypic diversity of the Helicobacter pylori vacA c region and its correlation with gastric disease outcomes
Introduction . Helicobacter pylori infection is a major cause of peptic ulcer and gastric adenocarcinoma. The infection pr...
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Advancing rapid diagnostics for bloodstream infections: a perspective on scattered light integrated collection technology
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