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Identification of GLDN+ odontogenic stem cells as crucial for human tooth development and regeneration
Identification of GLDN+ odontogenic stem cells as crucial for human tooth development and regeneration
The dental papilla (DP) is essential for the development of dentin and pulp. The extensive cellular heterogeneity within t...
ANKRD1 sustains a neurogenic BMSC niche and counters cognitive aging
ANKRD1 sustains a neurogenic BMSC niche and counters cognitive aging
Craniomaxillofacial bone marrow mesenchymal stromal cells (BMSCs) retaining neural crest–derived neurogenic niche is...
Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder
Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder
Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive degenerative disease in which the intricate mechanisms ...
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
Enamel, the hardest mineralized material in the human body, protects the underlying living tissues, the dentin and pulp of...
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation
Periodontitis is a common chronic inflammatory disease that ultimately results in irreversible tooth loss. Cementum, a bon...
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion
Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abr...
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities
Dento-maxillofacial abnormalities are highly prevalent and arise as a result of a variety of etiological factors, presenti...
Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice
Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice
Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such a...
Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition
Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition
Host-derived small RNAs are emerging as critical regulators in the dynamic interactions between host tissues and the micro...
Platelet methyltransferase-like protein 4-mediated mitochondrial DNA metabolic disorder exacerbates oral mucosal immunopathology in hypoxia
Platelet methyltransferase-like protein 4-mediated mitochondrial DNA metabolic disorder exacerbates oral mucosal immunopathology in hypoxia
Hypoxemia is a common pathological state characterized by low oxygen saturation in the blood. This condition compromises m...
Isolation methods of exosomes derived from dental stem cells
Isolation methods of exosomes derived from dental stem cells
Mesenchymal stem cells are highly regarded for their potential in tissue repair and regenerative medicine due to their mul...
Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery
Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery
Peri-implant keratinized mucosa (PIKM) augmentation refers to surgical procedures aimed at increasing the width of PIKM. C...
Correction: Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Author Correction: Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Author Correction: Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Correction to: International Journal of Oral Science https://doi.org/10.1038...
Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis
Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis
Radiochemotherapy-induced oral mucositis (OM) is a common oral complication in patients with tumors following head and nec...
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectio...
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately res...
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth mov...
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and a hig...
Expert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the r...
Expert consensus on irrigation and intracanal medication in root canal therapy
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant ...
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displa...
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multipl...
Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a hierarchically structured tiss...
Expert consensus on digital guided therapy for endodontic diseases
Expert consensus on digital guided therapy for endodontic diseases
Digital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic disease...
Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia
Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia
Elevated fibroblast growth factor 23 (FGF23) in X-linked hypophosphatemia (XLH) results in rickets and phosphate wasting, ...
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and me...
Molecular mechanisms of cellular metabolic homeostasis in stem cells
Molecular mechanisms of cellular metabolic homeostasis in stem cells
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-r...
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the ...
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