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FDA approves wearable device for pancreatic cancer
The US Food and Drug Administration (FDA) in February approved the first wearable device for treating locally advanced pan...
Site-specific engineering to produce CAR T cells in vivo
Generating chimeric antigen receptor (CAR) T cells in vivo offers a promising avenue for overcoming barriers limiting the ...
Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing
Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing
Protein kinases are central to cell signaling and key drug targets in cancer. To inform potential repurposing of kinase in...
Synthetic biology’s uncertain regulatory future in the wake of Loper Bright Enterprises v. Raimondo
The US Supreme Court’s decision in Loper Bright Enterprises v. Raimondo, along with federal spending cuts, may limit...
Deeper is not always better in plasma proteomics
Deeper is not always better in plasma proteomics
This Comment discusses depth, robustness and bias in plasma proteomics, concluding that increasing the depth of coverage d...
Reference-free discovery with barcoded single-cell sequencing
Reference-free discovery with barcoded single-cell sequencing
Single-cell RNA sequencing (scRNA-seq) analyses typically focus on alignment and differential gene expression, being blind...
Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering
Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering
Advanced genome editing technologies have enabled rapid, flexible rewriting of the Escherichia coli genome, but most have ...
High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics
High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics
Intravital fluorescence microscopy is hampered by optical aberrations arising from heterogeneous distributions of the refr...
Pricey sickle cell gene therapies primed for change
Bluebird Bio and Vertex Pharmaceuticals are the first to participate in a scheme to enable people with sickle cell disease...
Mushroom makes tasty eco-asphalt
Mushroom makes tasty eco-asphalt
Traditionally bitumen, which is made by crude oil distillation, has been used to bind gravel and sand to create our highwa...
Liver-avoiding capsids draw $1.1 billion
Novartis is shoring up its portfolio on gene therapies for inherited neuromuscular diseases by acquiring Kate Therapeutics...
Synthetic GPCRs for controlling cellular responses
Synthetic receptors, such as chimeric antigen receptors, are a powerful tool to modulate cell behavior for therapeutic pur...
Fresh from the biotech pipeline: FDA approvals settle in 2024, but what next?
Fresh from the biotech pipeline: FDA approvals settle in 2024, but what next?
After two volatile years, FDA approvals in 2024 settled closer to their 10-year average. Will nominated commissioner Marty...
A platform for the biomedical application of large language models
A platform for the biomedical application of large language models
Heidelberg University, Faculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, He...
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors
We introduce a quantum–classical generative model for small-molecule design, specifically targeting KRAS inhibitors ...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Spatial host–microbiome sequencing reveals niches in the mouse gut
Mucosal and barrier tissues, such as the gut, lung or skin, are composed of a complex network of cells and microbes formin...
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
The interactions of microorganisms among themselves and with their multicellular host take place at the microscale, formin...
Modeling human trunk development
Modeling human trunk development
A model of the embryonic human trunk attains a more mature developmental stage than previous models.
Antibiotic nanoparticles boost antitumor immunity
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T ce...
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and...
A bacterial assist for CAR-T cells
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