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Targeted isolation of piperazate-containing molecules: bioinformatics and spectroscopy
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Protein families secreted by nematodes to modulate host immunity
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Induced pluripotent stem cell–based tissue models to study malaria: a new player in the research game
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Can a microbial community become an evolutionary individual?
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How pathogens drive adipose tissue loss in the host
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Immune evasion runs in the family: two surface protein families of Plasmodium falciparum–infected erythrocytes
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The role of microbial succinate in the pathophysiology of inflammatory bowel disease: mechanisms and therapeutic potential
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Specialized biopolymers: versatile tools for microbial resilience
Specialized biopolymers: versatile tools for microbial resilience
Biopolymers are a chemically diverse group of high-molecular-weight molecules composed of repeating building blocks, such ...
Multilayered regulation of amino acid metabolism in Escherichia coli
Multilayered regulation of amino acid metabolism in Escherichia coli
Escherichia coli primarily constitutes 0.1–5% of the mammalian gut microbiome and can also be found in the gut of birds, r...
Unlocking the potential of optogenetics in microbial applications
Unlocking the potential of optogenetics in microbial applications
Optogenetics is a powerful approach that enables researchers to use light to dynamically manipulate cellular behavior. Sin...
Nutritional control of bacterial DNA replication
Nutritional control of bacterial DNA replication
All cells must ensure precise regulation of DNA replication initiation in coordination with growth rate and in response to...
PhoU: a multifaceted regulator in microbial signaling and homeostasis
PhoU: a multifaceted regulator in microbial signaling and homeostasis
Inorganic phosphate (Pi) is one of the essential molecules required for many biological processes, including synthesis of ...
Matching the β-oxidation gene repertoire with the wide diversity of fatty acids
Matching the β-oxidation gene repertoire with the wide diversity of fatty acids
Bacteria can use fatty acids (FAs) from their environment as carbon and energy source. This catabolism is performed by the...
The multifaceted roles of Myb domain–containing proteins in apicomplexan parasites
The multifaceted roles of Myb domain–containing proteins in apicomplexan parasites
The phylum of apicomplexan parasites is a large and diverse clade of protists that is responsible for significant diseases...
Crosstalk between (p)ppGpp and other nucleotide second messengers
Crosstalk between (p)ppGpp and other nucleotide second messengers
The remarkable ability of bacteria to colonize diverse habitats relies on their efficient response to environmental change...
Environmental adaptation and diversification of bacterial two-component systems
Environmental adaptation and diversification of bacterial two-component systems
Two-component systems (TCSs) are highly conserved signaling mechanisms that allow cells to sense and respond to diverse in...
Innovative and potential treatments for fungal central nervous system infections
Innovative and potential treatments for fungal central nervous system infections
Central nervous system (CNS) infections are caused by diverse microorganisms, including viruses, bacteria, fungi, and para...
Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm
Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm
The cell division cycle of T. gondii is driven by cyclically expressed ApiAP2 transcription factors (AP2s) that promote ge...
Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins
Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins
Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing condit...
Non-canonical food sources: bacterial metabolism of Maillard reaction products and its regulation
Non-canonical food sources: bacterial metabolism of Maillard reaction products and its regulation
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Evolution and synthetic biology
Evolution and synthetic biology
Evolutionary observations have often served as an inspiration for biological design. Decoding of the central dogma of life...
Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Throughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioacti...
The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology
The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology
Small proteins encoded by small open-reading frames (sORFs) (≤70 aa) were overlooked for decades due to methodological rea...
Structure-guided metagenome mining to tap microbial functional diversity
Structure-guided metagenome mining to tap microbial functional diversity
Scientists now have access to millions of accurate three-dimensional (3D) models of protein structures. How do we leverage...
The skin mycobiome and intermicrobial interactions in the cutaneous niche
The skin mycobiome and intermicrobial interactions in the cutaneous niche
Mammalian microbiomes have coevolved with their host to establish a stable homeostatic relationship. Multifaceted commensa...
Design of synthetic bacterial biosensors
Design of synthetic bacterial biosensors
Novel whole-cell bacterial biosensor designs require an emphasis on moving toward field deployment. Many current sensors a...
Interkingdom interactions between Pseudomonas aeruginosa and Candida albicans affect clinical outcomes and antimicrobial responses
Interkingdom interactions between Pseudomonas aeruginosa and Candida albicans affect clinical outcomes and antimicrobial responses
Infections that involve interkingdom microbial communities, such as those between bacteria and yeast pathogens, are diffic...
Bacteriophage communities are a reservoir of unexplored microbial diversity in neonatal health and disease
Bacteriophage communities are a reservoir of unexplored microbial diversity in neonatal health and disease
Acquisition and development of the gut microbiome are vital for immune education in neonates, especially those born preter...
Editorial overview: Turtles all the way down: Bacterial cell regulation across scales
Editorial overview: Turtles all the way down: Bacterial cell regulation across scales
Peter Chien studies molecular mechanisms of stress responses and protein turnover motivated by bacterial systems. He was t...
Conditionally unutilized proteins and their profound effects on growth and adaptation across microbial species
Conditionally unutilized proteins and their profound effects on growth and adaptation across microbial species
Protein synthesis is an important determinant of microbial growth and response that demands a high amount of metabolic and...
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