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Adaptive and innovative study design in rare diseases
Adaptive and innovative study design in rare diseases
Challenges in rare disease trialsRare diseases are defined in the European Union as ones that affect fewer than one person...
Natural history of otitis media with effusion-related hearing loss in children under 12 years: a systematic review
Natural history of otitis media with effusion-related hearing loss in children under 12 years: a systematic review
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Are lumbar punctures required for infants with bacteraemic urinary tract infections?
Are lumbar punctures required for infants with bacteraemic urinary tract infections?
ScenarioA 6-week-old girl is admitted with fevers, vomiting and a urine dipstick suggestive of a urinary tract infection (...
Consent and assent in paediatric practice: its the conversation that matters
Consent and assent in paediatric practice: its the conversation that matters
In paediatric medical research, across jurisdictions, parental consent and the assent of their child will usually come fro...
Tackling obesity while preventing obesity stigma
Tackling obesity while preventing obesity stigma
Obesity is a significant public health problem. Prevalence is rising in children and young people, with lifelong health im...
Children born to subfertile couples, how are they doing? Evidence from research
Children born to subfertile couples, how are they doing? Evidence from research
More than 10 million children have been born with assisted reproductive technology (ART) as we begin to enter the third ge...
Research on child and adolescent health in low- and middle-income countries in 2023-2024
Research on child and adolescent health in low- and middle-income countries in 2023-2024
Each year since 2002, evidence on child and adolescent health derived from randomised controlled trials (RCTs) in low- and...
Improving inpatient paediatric de-labelling of allergies to beta-lactams: a quality improvement study
Improving inpatient paediatric de-labelling of allergies to beta-lactams: a quality improvement study
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Outpatient and primary care direct provocation challenges for antibiotic allergy in children
Outpatient and primary care direct provocation challenges for antibiotic allergy in children
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Allergy to beta-lactam antibiotics in children: predictors for a positive oral challenge test
Allergy to beta-lactam antibiotics in children: predictors for a positive oral challenge test
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The underdiagnosis of asthma... insub-Saharan Africa
The underdiagnosis of asthma... insub-Saharan Africa
The International Study of Asthma and Allergies in Children (ISAAC) questionnaire was developed in the 1990s and has been ...
Covert medication in children: an extrapolation from adult practice
Covert medication in children: an extrapolation from adult practice
Parents smuggle antipyretics into their feverish infants. At the other end of this continuum, the clandestine administrati...
Epidemiology of childhood invasive pneumococcal disease in Australia: a prospective cohort study
Epidemiology of childhood invasive pneumococcal disease in Australia: a prospective cohort study
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Modifiable risk factors for developing otitis media with effusion in children under 12 years in high-income countries: a systematic review
Modifiable risk factors for developing otitis media with effusion in children under 12 years in high-income countries: a systematic review
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National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach
National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach
WHAT IS ALREADY KNOWN ON THIS TOPICIgA vasculitis is a small vessel vasculitis and the most frequently seen subtype in chi...
Associations between maternal body mass index and childhood infections in UK primary care: findings from the Born in Bradford birth cohort study
Associations between maternal body mass index and childhood infections in UK primary care: findings from the Born in Bradford birth cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICIncreased inflammation in utero is associated with changes to the developing fetal immu...
Nationwide, couple-based genetic carrier screening
Nationwide, couple-based genetic carrier screening
In most cases, a reproductive couple will only become aware of their increase chance of their offspring having an autosoma...
Lumps or granules?
Lumps or granules?
You may well enjoy a lump of sugar in your tea, a fine cucumber sandwich and a round of croquet. Or you could prefer a spr...
Cardiac output monitoring in children: a review
Cardiac output monitoring in children: a review
AbstractCardiac output monitoring enables physiology-directed management of critically ill children and aids in the early ...
Atoms
Atoms
The new turquoiseA good case could be made for awarding the dynamics of etymology the (centuries overdue) ‘official’ eight...
Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review
Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review
WHAT IS ALREADY KNOWN ON THIS TOPICA search in PubMed returns nearly half a million articles - an unwieldy and unmanageabl...
Risk of suicide in children and adolescents in the emergency department--is universal screening the answer?
Risk of suicide in children and adolescents in the emergency department--is universal screening the answer?
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Tunnelled external versus implanted port central venous catheters in paediatric oncology: a systematic review and meta-analysis
Tunnelled external versus implanted port central venous catheters in paediatric oncology: a systematic review and meta-analysis
WHAT IS ALREADY KNOWN ON THIS TOPICComplications associated with central venous catheters (CVCs) in children with cancer a...
Role of urine culture in paediatric patients with cancer with fever and neutropenia: a prospective observational study
Role of urine culture in paediatric patients with cancer with fever and neutropenia: a prospective observational study
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Public awareness of childhood, teenager and young adult cancer signs and symptoms in Great Britain: a cross-sectional survey
Public awareness of childhood, teenager and young adult cancer signs and symptoms in Great Britain: a cross-sectional survey
IntroductionChildhood cancer has been declared a global disease burden by the World Health Organization.1 It is the leadin...
Variation in access and prescription of vedolizumab and ustekinumab in paediatric patients with inflammatory bowel disease: a UK-wide study
Variation in access and prescription of vedolizumab and ustekinumab in paediatric patients with inflammatory bowel disease: a UK-wide study
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Positive urine cultures
Positive urine cultures
We now have a culture-free reference standard for identifying bacterial presence in clinical specimens; the 16S ribosomal ...
When a Kasai portoenterostomy goes wrong
When a Kasai portoenterostomy goes wrong
The first job Archivist had in paediatrics was working as an SHO on the gastroenterology ward in a children’s hospital in ...
Message to the new prime minister (whoever this might be)
Message to the new prime minister (whoever this might be)
The country is in serious difficulties. Here I suggest a course of action alternative to that pursued by recent administra...
Perceived influence of commercial milk formula labelling on mothers feeding choices in Great Britain: a qualitative study
Perceived influence of commercial milk formula labelling on mothers feeding choices in Great Britain: a qualitative study
WHAT IS ALREADY KNOWN ON THIS TOPICSophisticated and well-funded marketing strategies are used to sell commercial milk for...
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