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Network pharmacology analysis and experimental validation of modified Taohong Siwu decoction against atherosclerosis
Network pharmacology analysis and experimental validation of modified Taohong Siwu decoction against atherosclerosis
The modified Taohong Siwu decoction (MTHSWD), a traditional prescription, demonstrates notable efficacy in treating cardio...
Dynamics of viability and apoptotic regulation in chicken ileal explant culture
Dynamics of viability and apoptotic regulation in chicken ileal explant culture
The development of a reliable ex vivo intestinal model is essential for studying gut physiology and host–microbe int...
VEGFA is essential for the potentiation of ATRA on BMP9-induced osteogenesis of preadipocytes and osteoporotic fracture healing
VEGFA is essential for the potentiation of ATRA on BMP9-induced osteogenesis of preadipocytes and osteoporotic fracture healing
The induction of osteogenic differentiation in preadipocytes may serve as a potential therapeutic approach for treating os...
The differential expression of lipocalin-2 in pig tissues and its molecular mechanism of regulating cell viability, differentiation, adipogenesis, and glycometabolism in porcine intramuscular preadipocytes
The differential expression of lipocalin-2 in pig tissues and its molecular mechanism of regulating cell viability, differentiation, adipogenesis, and glycometabolism in porcine intramuscular preadipocytes
Lipocalin-2 (LCN-2) is an adipocytokine secreted mainly by adipose tissue. Increasing evidences suggest that LCN-2 is an i...
Mechanisms of Xinwei Tang in stress-induced gastric dysmotility: evidence from rat and In Vitro models
Mechanisms of Xinwei Tang in stress-induced gastric dysmotility: evidence from rat and In Vitro models
Stress is a key trigger of gastric dysmotility, partly via mitochondrial dysfunction and disordered gut–brain hormon...
Comparative pathophysiological modeling: the advantage of “two-hit” over “one-hit” in acute liver failure studies
Comparative pathophysiological modeling: the advantage of “two-hit” over “one-hit” in acute liver failure studies
Acute liver failure (ALF), a life-threatening condition marked by rapid hepatocyte death and systemic inflammation, poses ...
A preliminary study on the mechanism of stromal interaction molecule 1 (STIM1) involvement in Adriamycin-induced podocyte injury
A preliminary study on the mechanism of stromal interaction molecule 1 (STIM1) involvement in Adriamycin-induced podocyte injury
Cellular metabolic reprogramming is intimately linked to various physiological and pathological processes. For instance, c...
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling
Intervertebral disc degeneration (IVDD), a natural aging process, leads to intervertebral disc pain, with lumbar resection...
miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression
miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression
This study aimed to explore the function of miR-495-3p in cerebral ischemia-reperfusion injury (CI/RI) and reveal its pote...
Construction of tissue-engineered vascular sinoatrial node in vitro
Construction of tissue-engineered vascular sinoatrial node in vitro
To develop a biological pacemaker by differentiating rabbit BMSCs into vascular endothelial cells (VECs) and pacemaker-lik...
Decorin inhibits the migration and invasion of the LPS + high glucose–induced primary trophoblast cell through ADAMTS12
Decorin inhibits the migration and invasion of the LPS + high glucose–induced primary trophoblast cell through ADAMTS12
Decorin was identified as the most relevant biomarker in type 2 diabetes or obesity-related diseases, but its function in ...
Mechanism of LPS-activated gingival fibroblasts promote the migration of gastric cancer cells via CXCL12/CXCR4-Snail2-EMT axis
Mechanism of LPS-activated gingival fibroblasts promote the migration of gastric cancer cells via CXCL12/CXCR4-Snail2-EMT axis
The objective of this article is to explore the influence and process by which periodontitis affects the metastasis of gas...
Elevated intravesical pressure promotes circulating tumor cell release in an orthotopic mouse model of bladder cancer
Elevated intravesical pressure promotes circulating tumor cell release in an orthotopic mouse model of bladder cancer
Elevated intravesical pressure during transurethral resection of bladder tumor (TURBT) is hypothesized to facilitate the r...
miR-3614-5p prevents endothelial differentiation and angiogenesis in human exfoliated deciduous teeth by targeting lysophosphatidic acid receptor 2
miR-3614-5p prevents endothelial differentiation and angiogenesis in human exfoliated deciduous teeth by targeting lysophosphatidic acid receptor 2
The contribution of microRNAs (miRNAs) to the endothelial differentiation of stem cells from human exfoliated deciduous te...
Ginsenoside F1 ameliorates nonalcoholic fatty liver disease by activating the AMPK/PGC-1α pathway and autophagy
Ginsenoside F1 ameliorates nonalcoholic fatty liver disease by activating the AMPK/PGC-1α pathway and autophagy
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases globally, and currently, the...
In vitro culture for long-term maintenance of embryonic insect cells from the house cricket
In vitro culture for long-term maintenance of embryonic insect cells from the house cricket
Insect cell culture has become foundational for many areas of research and biotechnological innovation, yet major taxonomi...
Correction: The effect of IGF-1 on cartilage injury in bone marrow mesenchymal stem cells through the BMP2-Smad1/5 signaling pathway
Correction: The effect of IGF-1 on cartilage injury in bone marrow mesenchymal stem cells through the BMP2-Smad1/5 signaling pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License...
Cabozantinib activates TFEB-mediated autophagy to exert anti-tumor effects in hepatocellular carcinoma
Cabozantinib activates TFEB-mediated autophagy to exert anti-tumor effects in hepatocellular carcinoma
Autophagy signaling plays a crucial yet complex role in hepatocellular carcinoma (HCC), influencing tumor progression and ...
Integrated assessment of graphene oxide and graphitic carbon nitride nanoparticles: from synthesis to in vitro biological impact on zebrafish () cell models
Integrated assessment of graphene oxide and graphitic carbon nitride nanoparticles: from synthesis to in vitro biological impact on zebrafish () cell models
Graphene and its derivatives have been increasingly explored for various biomedical applications. Despite their promising ...
RYK silencing-modified bone marrow-derived mesenchymal stem cells suppress gastric cancer progression
RYK silencing-modified bone marrow-derived mesenchymal stem cells suppress gastric cancer progression
Gastric cancer (GC) is a prevalent malignant tumor threatening human health. This study aimed to explore the potential mec...
5-Methoxytryptophan improves cerebrovascular injury induced by chronic kidney disease through NF-κB pathway
5-Methoxytryptophan improves cerebrovascular injury induced by chronic kidney disease through NF-κB pathway
5-Methoxytryptophan (5-MTP), a candidate biomarker for chronic kidney disease (CKD), has an undefined role in cerebrovascu...
Cyto-genotoxic assessment of bisphenol P through expression of DNA damage/repair genes in MDBK cell line
Cyto-genotoxic assessment of bisphenol P through expression of DNA damage/repair genes in MDBK cell line
Bisphenol P (BPP) is a recognized endocrine disruptor with detrimental effects on human health. This study aimed to evalua...
Bone marrow–derived mesenchymal stem cells and their extracellular vesicles suppress splenocyte activation and ameliorate experimental autoimmune encephalomyelitis
Bone marrow–derived mesenchymal stem cells and their extracellular vesicles suppress splenocyte activation and ameliorate experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is a neurodegenerative and autoimmune disease affecting the central nervous system (CNS). Recently...
Adhesion extracellular matrix proteins improve in vitro cellular and functional properties of enriched caprine adult dermal fibroblast
Adhesion extracellular matrix proteins improve in vitro cellular and functional properties of enriched caprine adult dermal fibroblast
The study was supported by a grant from the National Livestock Mission (NLM) (Grant No. R-99011(11)9/2022-DADF-Dept (E-232...
Functions of ectodysplasin A2 receptor (EDA2R) in inducing capacitation of sperm in mice
Functions of ectodysplasin A2 receptor (EDA2R) in inducing capacitation of sperm in mice
Sperm capacitation, a prerequisite for fertilization, is regulated not only by intrinsic signaling but also by paracrine f...
Role of PDGFRα-mediated signalling in anoikis resistance in glioblastoma: in vitro study
Role of PDGFRα-mediated signalling in anoikis resistance in glioblastoma: in vitro study
Anoikis resistance, the evasion of programmed cell death when cells detach from the extracellular matrix (ECM), is a criti...
Exploring the effects of roscovitine, serum starvation, and contact inhibition at G/G arrest in northern tiger cat dermal fibroblasts
Exploring the effects of roscovitine, serum starvation, and contact inhibition at G/G arrest in northern tiger cat dermal fibroblasts
Nuclear reprogramming studies are important tools in conserving wild felids, with efficacy depending on efficient G0/G1 ce...
Establishment of a method to evaluate the dynamics of highly chemotactic THP-1 cells during differentiation into monocyte-M1 macrophage-like cells
Establishment of a method to evaluate the dynamics of highly chemotactic THP-1 cells during differentiation into monocyte-M1 macrophage-like cells
Differentiation of the human monocytic leukemia cell line THP-1 is widely used to analyze the function of monocyte/macroph...
Nuclear protein 1 protects against neonatal hypoxic-ischemic encephalopathy by inhibiting neuronal ferroptosis by improving iron storage
Nuclear protein 1 protects against neonatal hypoxic-ischemic encephalopathy by inhibiting neuronal ferroptosis by improving iron storage
Recent studies have highlighted the role of ferroptosis in neuronal damage during neonatal hypoxic-ischemic encephalopathy...
Optimization of a protocol for the high-yield isolation of active muscle stem cells from bovine skeletal muscle tissue
Optimization of a protocol for the high-yield isolation of active muscle stem cells from bovine skeletal muscle tissue
Beef is primarily made up of skeletal muscle tissue. Therefore, the cultivation of bovine muscle stem cells (MSCs) to prov...
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