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The neural niche in cancer: mechanistic insights into tumor–neuron–immune crosstalk and therapeutic opportunities
The nervous system is increasingly recognized as a dynamic and regulatory component of the tumor microenvironment playing ...
Correction: Exosomal lncRNA XR_001793654.1 in human cardiac explant-derived alleviates atrial fibrillation via abolishing the miR-107-3p-mediated KLF13 inhibition
There was a mistake in Figure 1D as published.XR_001793654–1 exhibits high expression in the human CDC-derived EVs. (A) Tr...
Cancer-associated fibroblast heterogeneity and its role in reshaping immunotherapy in solid cancers: potential strategies and clinical promise
Cancer-associated fibroblasts (CAFs) are important components of the solid tumour microenvironment (TME). CAFs have long b...
In vitro assays to monitor membrane fusion
Membrane fusion is essential to maintain eukaryotic life. Fusion is tightly regulated and relies on a complex network of p...
Sodium pyruvate ameliorates cognitive dysfunction by expanding hippocampal endogenous neural stem cells in tBCCAO mice
BackgroundAfter a stroke, many survivors experience post-stroke cognitive impairment (PSCI), a frequent clinical problem t...
Persistent organic pollutants and prostate cancer: multiple mechanisms and comprehensive control strategies
Persistent organic pollutants (POPs) are a class of chemical substances with environmental persistence, bioaccumulation, a...
Garciniagifolone A, derived from Garcinia multiflora fruits, inhibits triple-negative breast cancer cells and organoids growth by targeting CA9
The Garcinia multiflora. is not only a delicious fruit that can be consumed directly, but also contains abundant medicinal...
H19 and IGF2 imprinting from embryogenesis to oncogenesis
The imprinted H19/IGF2 locus is critical for fetal development and, when dysregulated, contributes to tumorigenesis. This ...
Epigenetic crosstalk in neuroblastoma development and progression
Neuroblastoma (NB), a pediatric malignancy of the peripheral nervous system, accounts for 15% of pediatric cancer deaths a...
Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish
IntroductionThe decline of mitochondrial homeostasis and proteostasis, the two key cell quality control mechanisms, is the...
Iron toxicity undermines microfracture-induced cartilage regeneration by predisposing a pre-ferroptotic niche
Microfracture (MF) often yields regenerated cartilage that resembles scar tissue and is prone to rapid deterioration. This...
PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade
IntroductionPRMT5 inhibitors are under clinical investigation for pancreatic ductal adenocarcinoma (PDAC), but strategies ...
Efficacy and safety of autologous cell-based therapies for atrophic acne scar treatment: an updated systematic review and meta-analysis with in-depth methodological and clinical insights
BackgroundAtrophic acne scars represent a therapeutic challenge with significant psychosocial impact. Autologous cell-base...
Gatm ablation disrupts spermatogenesis by impairing ribosome biogenesis and coupling defective steroid biosynthesis to immunoglobulin silencing
BackgroundGlycine amidinotransferase (GATM) catalyzes the rate-limiting step in creatine biosynthesis, a pathway essential...
Role and mechanism of mesenchymal stem cells in endometrial receptivity remodeling
Endometrial receptivity (ER) is a pivotal determinant of successful embryo implantation, and its dysfunction is a major ca...
Resolving tooth development at single-cell resolution: advancing dental regeneration
Tooth development is a continuous, highly orchestrated process that serves as an ideal model for dissecting the cellular a...
Research advances in extracellular vesicles for diagnosis and treatment of genitourinary cancers
Extracellular vesicles (EVs) have emerged as vital mediators of intercellular communication, playing crucial roles in the ...
EGF-loaded, bioactive-rich Panax notoginseng-derived nanovesicles accelerate skin wound healing
Wound healing is a complex physiological process involving homeostasis, inflammation, proliferation, migration and tissue ...
Correction: Diagnostic performance and generalizability of deep learning for multiple retinal diseases using bimodal imaging of fundus photography and optical coherence tomography
A Correction on Diagnostic performance and generalizability of deep learning for multiple retinal diseases using bimodal i...
Editorial: Cellular and molecular pathologies of Alzheimer’s disease: understanding the link between different etiological factors for therapeutic exploitation
Siano and colleagues provided evidence that soluble, nuclear microtubule associated protein tau (MAPT/tau) associated with...
Advances and prospects of precision nanomedicine in personalized tumor theranostics
1 IntroductionTumor, or cancer, is a disease characterized by abnormal proliferation and growth of cells, which can occur ...
Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration
1 IntroductionThe negative consequences that arise from glottic insufficiency include difficulty of speaking, breathing or...
Erratum: Embryonic temperature has long-term effects on muscle circRNA expression and somatic growth in Nile tilapia
An erratum on: Rbbani G, Murshed R, Siriyappagouder P, Sharko F, Nedoluzhko A, Joshi R, Galindo-Villegas J, Raeymaekers JA...
miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells
IntroductionDuring the development of the vertebrate central nervous system (CNS), multipotent neural stem/progenitor cell...
Paternal impact on the developmental programming of sexual dimorphism
IntroductionSexual dimorphism (SDM) refers to the phenotypic variations between males and females within the same species....
Applications of artificial intelligence in regenerative dentistry: promoting stem cell therapy and the scaffold development
1 IntroductionRecently, AI has grown in a number of ways thanks to developments in needs of computer hardware, software, a...
Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling
1 IntroductionCalcium is viewed as a vital signaling molecule that regulates many important physiological processes includ...
Impact of galectin-3 on neurotrophic factor expression by PCR array: potential implications for the human cornea
IntroductionThe cornea is highly innervated, containing a dense network of sensory nerve fibers primarily originating from...
An improved method for whole-mount in situ hybridization in regenerating tails of Xenopus laevis tadpoles
1 IntroductionOne of the most frequently used methods in the concept of “seeing is believing” is in situ hybridization, wh...
T-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions
1 IntroductionAdipose tissue, a subtype of connective tissue, encompasses a diverse array of cell types, including stem/pr...
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