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Changes in gene expression in healthcare workers during night shifts: implications for immune response and health risks
Changes in gene expression in healthcare workers during night shifts: implications for immune response and health risks
Shift work is common in healthcare, especially in emergency and intensive care, to maintain the quality of patient care. N...
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024
The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 20...
Gut integrity in intensive care: alterations in host permeability and the microbiome as potential therapeutic targets
Gut integrity in intensive care: alterations in host permeability and the microbiome as potential therapeutic targets
The gut has long been hypothesized to be the “motor” of critical illness, propagating inflammation and playing...
Erythropoietin as a critical prognostic indicator in ICU patients with sepsis: a prospective observational study
Erythropoietin as a critical prognostic indicator in ICU patients with sepsis: a prospective observational study
Erythropoietin (EPO), a glycoprotein hormone primarily produced in the kidneys, plays pleiotropic roles in hematopoietic a...
The Japanese Critical Care Nutrition Guideline 2024
The Japanese Critical Care Nutrition Guideline 2024
Nutrition therapy is important in the management of critically ill patients and is continuously evolving as new evidence e...
Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation
Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation
Authors and AffiliationsNon-Profit Organization ICU Collaboration Network (ICON), 2-15-13 Hongo, Bunkyo-Ku, Tokyo, 113-003...
Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee c...
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Heterogeneity among critically ill patients undergoing invasive mechanical ventilation (IMV) treatment could result in hig...
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database
Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients with and without...
Optimized ventilation power to avoid VILI
Optimized ventilation power to avoid VILI
The effort to minimize VILI risk must be multi-pronged. The need to adequately ventilate, a key determinant of hazardous p...
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis w...
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Unfractionated heparin (UFH) is primarily monitored using activated partial thromboplastin time (APTT). However, the recen...
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study
Neuromuscular blockade agents (NMBAs) can be used to facilitate mechanical ventilation in critically ill patients. Accumul...
Translation of patients’ advance directives in intensive care units: are we there yet?
Translation of patients’ advance directives in intensive care units: are we there yet?
This review examined studies regarding the implementation and translation of patients’ advance directives (AD) in in...
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/p...
Lacosamide dosing in patients receiving continuous renal replacement therapy
Lacosamide dosing in patients receiving continuous renal replacement therapy
Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosami...
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant ...
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients
Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020; Japanese ...
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study
The aims of this study were to evaluate the efficacy, safety, and pharmacokinetics (PK) of continuous intravenous administ...
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study
Previous studies have reported conflicting results regarding fresh frozen plasma (FFP)-to-red blood cell (RBC) ratio and p...
Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in...
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study
The prognosis for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is poor, and there is no established treatm...
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study
Gasping during resuscitation has been reported as a favorable factor for out-of-hospital cardiac arrest. We examined wheth...
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury
Mechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mecha...
A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound
A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound
This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, ...
Ultrasonographic evaluation of the diaphragm in critically ill patients to predict invasive mechanical ventilation
Ultrasonographic evaluation of the diaphragm in critically ill patients to predict invasive mechanical ventilation
Diaphragm dysfunction is common in critically ill patients and associated with poorer outcomes. The function of the diaphr...
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study
Diaphragmatic dysfunction often occurs after adult cardiovascular surgery. The prognostic effect of diaphragmatic dysfunct...
Comparison of balanced and unbalanced crystalloids as resuscitation fluid in patients treated for cardiogenic shock
Comparison of balanced and unbalanced crystalloids as resuscitation fluid in patients treated for cardiogenic shock
The efficacy and safety of saline versus balanced crystalloid solutions in ICU-patients remains complicated by exceptional...
Ability of the respiratory ECMO survival prediction (RESP) score to predict survival for patients with COVID-19 ARDS and non-COVID-19 ARDS: a single-center retrospective study
Ability of the respiratory ECMO survival prediction (RESP) score to predict survival for patients with COVID-19 ARDS and non-COVID-19 ARDS: a single-center retrospective study
The respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal...
Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial
Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial
Previous studies show positive effect of music on reducing anxiety, pain, and medication requirement. Anxiety has become a...
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