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Dexmedetomidine for acute respiratory conditions requiring non-invasive respiratory support in pediatric and adult patients: systematic review and meta-analysis of the literature
BackgroundDexmedetomidine is increasingly used as an anxiolytic and sedative in pediatric patients with acute respiratory ...
Telemedicine applications in general medicine - a structured review of the evidence
IntroductionTelemedicine (TM) in general practice has declined following the pandemic. One reason is deemed to be the lack...
Efficacy and safety of transcutaneous electrical acupoint stimulation to assist bowel cleansing: study protocol for a single-center, single-blind, randomized controlled trial
IntroductionHigh-quality bowel preparation is a crucial prerequisite for ensuring the effectiveness of colonoscopy. Althou...
Examining the association between AI-enhanced education and medical students’ self-directed learning using an integrated TAM-UTAUT2 model
BackgroundArtificial intelligence (AI)-assisted education has become an increasingly important instructional model in medi...
Electroacupuncture in the treatment of non-alcoholic fatty liver disease: mechanistic insights and therapeutic potential
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disorder globally, driven by increas...
The role of epigenetic modifications in cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) constitute a heterogeneous population of stromal cells whose tumor-modulating activit...
Expression of Claudin-18.2 in pancreatic ductal adenocarcinoma: a systematic review and meta-analysis
BackgroundClaudin-18.2 (CLDN18.2), a tight junction protein, has emerged as a promising molecular target in gastrointestin...
Beyond infection—a ferritin-LDH-IL-10 triad to unmask intravascular lymphoma in fever of unknown origin: a case report and literature review
ObjectiveTo highlight the diagnostic value of the ferritin-LDH-IL-10 triad and image-guided targeted biopsy in intravascul...
Applying Van den Akker’s Spider Web Model to curriculum design in medical education: a practical guide
Contemporary medical education requires curriculum models that ensure coherence, alignment, and adaptability to rapid tech...
Short-term changes in bodily pain and associated baseline factors in patients with fibromyalgia receiving paraprobiotic supplementation: a retrospective observational study
BackgroundFibromyalgia is characterized by heterogeneous pain trajectories, and short-term clinical improvement may vary a...
Comparative clinical features and outcomes of invasive pulmonary aspergillosis following influenza versus COVID-19: a retrospective cohort study
Background and aimPatients with influenza or Coronavirus disease 2019 (COVID-19) are at risk of developing invasive pulmon...
Multidimensional machine learning for early neurological deterioration prediction in acute ischemic stroke
ObjectiveThis study aimed to develop and validate a multidimensional clinical feature-based machine learning model for acc...
Conservative versus liberal oxygen therapy for mechanically ventilated patients: a systematic review and meta-analysis of randomized controlled trials
BackgroundCurrently, clinicians lack sufficient evidence to determine which oxygen therapy approach yields better outcomes...
Barriers and facilitators to weight loss in patients living with obesity and OSAHS: a qualitative study based on the Theoretical Domains Framework (TDF)
BackgroundWeight loss represents a cornerstone therapy for individuals living with obesity and obstructive sleep apnea-hyp...
Ciprofol-etomidate versus propofol-etomidate for gastrointestinal endoscopy: a randomized, double-blind controlled clinical trial
ObjectiveExplore the clinical efficacy and safety of ciprofol-etomidate (C-E) versus propofol-etomidate (P-E) for gastroin...
Digital affordances of AI chatbots in nursing education: a systematic review of learning gains and gaps in the evidence
BackgroundDigital affordances refer to the possibilities provided by digital environments for learners. In the context of ...
Quantitative evaluation of 3D-printed physiological visualization tools in enhancing interns’ knowledge retention and application
BackgroundTraditional physiology teaching relies on 2D materials and static specimens, making it difficult to intuitively ...
Association between the aMAP risk score and mortality in the MASLD/MetALD/ALD patient population: a cohort study
BackgroundThe age–male–ALBI–platelets (aMAP) risk score, an emerging non-invasive marker for liver fibrosis and hepatocell...
Ultrawidefield OCTA study for the impact of PPVP on the structure and blood flow of the retina and choroid
ObjectiveTo investigate the association between the posterior precortical vitreous pocket (PPVP) and retinal morphological...
Publication lag in interventional, RCT-based meta-analyses within top-tier general medical journals and the CDSR: a protocol for a meta-epidemiological study
IntroductionSystematic reviews and meta-analyses serve as the cornerstone of clinical guidelines, yet their validity hinge...
Case report: An incidental finding of a left-sided supernumerary kidney
1 Introduction A supernumerary kidney is an extremely rare congenital renal anomaly, characterized by the presence of on...
Multilevel subdural and epidural hematoma after percutaneous kyphoplasty (PKP): a case report and literature review
Background PKP is an effective method for the treatment of osteoporotic fractures and some vertebral bone tumors, and mo...
The impact of COVID-19 pandemic on nosocomial infections in the cardiac care unit of a non-epidemic hospital in China
Introduction The COVID-19 outbreak in rapidly spread from Wuhan at the end of 2019. A study involving 72,314 cases revea...
Association between albumin changes and prognosis in older patients with acute myocardial infarction
1 Introduction Acute myocardial infarction (AMI), a type of myocardial necrosis usually caused by blockage of coronary a...
Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study
1 Introduction Sepsis, a dangerous dysfunction of the body’s organs, occurs when the body’s response to infection is not...
Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort
1 Introduction Coeliac disease (CD) is a chronic immune-mediated enteropathy, triggered by dietary gluten in genetically ...
Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review
1 Introduction Mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) represents an exceedingly rare mali...
Eosinophilic esophagitis in the “atopic march”: dupilumab as an “umbrella” strategy for multiple coexisting atopic diseases
1 Introduction Eosinophilic esophagitis (EoE) is a chronic, antigen-driven, T2 disease, characterized by eosinophilic inf...
The evolution of cell-free fetal DNA testing: expanded non-invasive prenatal testing and its effect on target populations
1 Introduction Chromosomal abnormalities impact the success rate of assisted reproduction and also contribute to early mi...
Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond
Introduction Systemic Autoimmune Rheumatic Diseases (SARDs) are a group of immune-mediated disorders characterized by div...
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