Comparative peptidomic profile and bioactivities of , L. after simulated gastrointestinal digestion

Mojica L, Luna-Vital DA, Me G (2017) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress. J Agric Food Chem 97(8):2401–2410. https://doi.org/10.1002/jsfa.8053

Article  CAS  Google Scholar 

Xu S, Zhao Y, Song W, Zhang C, Wang Q, Li R, Shen Y, Gong S, Li M, Sun L (2023) Improving the sustainability of processing by-products: extraction and recent biological activities of collagen peptides. Foods 12(10):1965. https://doi.org/10.3390/foods12101965

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brodkorb A, Egger L, Alminger M (2019) INFOGEST static in vitro simulation of gastrointestinal food digestion. Nat Protoc 14(4):991–1014. https://doi.org/10.1038/s41596-018-0119-1

Article  CAS  PubMed  Google Scholar 

Francielle MM, Gabriela BR, Ruann JC (2024) Multifunctional properties of peptides derived from black cricket (Gryllus assimilis) and effects of in vitro digestion simulation on their bioactivities. Food Res Int 196:115134. https://doi.org/10.1016/j.foodres.2024.115134

Article  CAS  Google Scholar 

Du A, Jia W (2023) Bioaccessibility of novel antihypertensive short-chain peptides in goat milk using the INFOGEST static digestion model by effect-directed assays. Food Chem 427:136735. https://doi.org/10.1016/j.foodchem.2023.136735

Article  CAS  PubMed  Google Scholar 

Yuan Y, Li C, Zheng Q, Wu J, Zhu K, Shen X, Cao J (2019) Effect of simulated gastrointestinal digestion in vitro on the antioxidant activity, molecular weight and microstructure of polysaccharides from a tropical sea cucumber (Holothuria leucospilota). Food Hydrocolloids 89:735–741. https://doi.org/10.1016/j.foodhyd.2018.11.040

Article  CAS  Google Scholar 

Du C, Gong H, Zhao H, Wang P (2024) Recent progress in the preparation of bioactive peptides using simulated gastrointestinal digestion processes. Food Chem 453:139587. https://doi.org/10.1016/j.foodchem.2024.139587

Article  CAS  PubMed  Google Scholar 

Mudgil P, Kamal H, Priya Kilari B, Mohd Salim MAS, Gan CY, Maqsood S (2021) Simulated gastrointestinal digestion of camel and bovine casein hydrolysates: identification and characterization of novel anti-diabetic bioactive peptides. Food Chem 353:129374. https://doi.org/10.1016/j.foodchem.2021.129374

Article  CAS  PubMed  Google Scholar 

Harnedy PA, FitzGerald RJ (2012) Bioactive peptides from marine processing waste and shellfish: a review. J Funct Foods 4(1):6–24. https://doi.org/10.1016/j.jff.2011.09.001

Article  CAS  Google Scholar 

Hu S, Chen W (2025) Recent progress in the preparation, purification, characterization, encapsulation, and biological activities of peptides from shellfish. Food Chem 495(Pt 2):146415. https://doi.org/10.1016/j.foodchem.2025.146415

Article  CAS  PubMed  Google Scholar 

Xing L, Wang Z, Hao Y, Zhang W (2022) Marine products as a promising resource of bioactive peptides: update of extraction strategies and their physiological regulatory effects. J Agric Food Chem 70(10):3081–3095. https://doi.org/10.1021/acs.jafc.1c07868

Article  CAS  PubMed  Google Scholar 

Yang D, Zhang Q, Wang Q, Chen L, Liu Y, Cong M, Wu H, Li F, Ji C, Zhao J (2018) A defensin-like antimicrobial peptide from the manila clam Ruditapes philippinarum: investigation of the antibacterial activities and mode of action. Fish Shellfish Immunol 80:274–280. https://doi.org/10.1016/j.fsi.2018.06.019

Article  CAS  PubMed  Google Scholar 

Wang Q, Liu FJ, Wang XM, Zhao GH, Cai D, Yu JH, Yin FW, Zhou DY (2022) Preparation and hepatoprotective activities of peptides derived from mussels (Mytilus edulis) and clams (Ruditapes philippinarum). Mar Drugs 20(11):719. https://doi.org/10.3390/md20110719

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu D, Yuan Z, Wu D, Wu C, El-Seedi HR, Du M (2023) The dual-function of bioactive peptides derived from oyster (Crassostrea gigas) proteins hydrolysates. Food Sci Hum Well 12(5):1609–1617. https://doi.org/10.1016/j.fshw.2023.02.006

Article  CAS  Google Scholar 

Mao ZJ, Jiang H, Sun JN (2024) Research progress in the preparation and structure-activity relationship of bioactive peptides derived from aquatic foods. Trends Food Sci Technol 147:104443. https://doi.org/10.1016/j.tifs.2024.104443

Article  CAS  Google Scholar 

Rambli MM, Phuah ET, Howell NK (2025) Nutritional and functional properties of underutilized shellfish (molluscs), limpet (Patella vulgata). Sci Rep 15(1):23130. https://doi.org/10.1038/s41598-025-08135-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rongan C, Xuemin Z, Jingjing D (2025) Effect of ultrasonic treatment on the in vitro digestibility properties of black bean protein. Sci Technol Food Ind 64(3):143–150. https://doi.org/10.13386/j.issn1002-0306.2024020141

Article  Google Scholar 

Wang X, Deng Y, Xie P, Liu L, Zhang C, Cheng J, Zhang Y, Liu Y, Huang L, Jiang J (2023) Novel bioactive peptides from ginkgo biloba seed protein and evaluation of their alpha-glucosidase inhibition activity. Food Chem 404(Pt A):134481. https://doi.org/10.1016/j.foodchem.2022.134481

Article  CAS  PubMed  Google Scholar 

Xia Z, Miao J, Chen B, Guo J, Ou Y, Liang X, Yin Y, Tong X, Cao Y (2022) Purification, identification, and antioxidative mechanism of three novel selenium-enriched oyster antioxidant peptides. Food Res Int 157:111359. https://doi.org/10.1016/j.foodres.2022.111359

Article  CAS  PubMed  Google Scholar 

Moon SH, Cho SJ (2023) Evaluation of the antioxidant activity of Tetraselmis chuii after in vitro gastrointestinal digestion and investigation of its antioxidant peptides. Algal Res 76:103328. https://doi.org/10.1016/j.algal.2023.103328

Article  Google Scholar 

Zheng XQ, Chi H, Ma S (2023) Identification of novel α-glucosidase inhibitory peptides in rice wine and their antioxidant activities using in silico and in vitro analyses. LWT 178:114629. https://doi.org/10.1016/j.lwt.2023.114629

Article  CAS  Google Scholar 

Ren H, Qin T, Zhou Q, Pan L, Yu C, Wang Y, Fan W, Li Z, Zheng Y (2025) Preparation, purification and identification of antioxidant peptides from the placenta of Tibetan sheep. Food Biosci 63:105560. https://doi.org/10.1016/j.fbio.2024.105560

Article  CAS  Google Scholar 

Li N, Liu K, Zhang Y, Hui Z, Wang P, Sun S, Du C (2025) Identification of novel alpha-glucosidase inhibitory peptides in Meretrix meretrix Linnaeus and their inhibitory kinetics using in silico and in vitro analyses. Int J Biol Macromol 309(Pt 1):142480. https://doi.org/10.1016/j.ijbiomac.2025.142480

Article  CAS  PubMed  Google Scholar 

Sun S, Hui Z, Liu K, Li N, Tang W, Zhang Y, Wang P, Du C (2025) Novel immunomodulatory peptides identified from Meretrix meretrix L. hydrolysates through in vitro cell experiments, in silico analysis, molecular docking, and dynamic simulation. J Funct Foods 127:106750. https://doi.org/10.1016/j.jff.2025.106750

Article  CAS  Google Scholar 

Li Z, Abou-Elsoud M, Chen H, Shu D, Ren S, Ahn DU, Huang X (2024) Identification and molecular mechanism of novel two-way immunomodulatory peptides from ovalbumin: in vitro cell experiments, de novo sequencing, and molecular docking. J Agric Food Chem 72(17):9856–9866. https://doi.org/10.1021/acs.jafc.4c00203

Article  CAS  PubMed  Google Scholar 

Du Y, Zhu S, Wang R, Chen X, Cai K (2022) Isolation and identification of anti-inflammatory peptide from goose blood hydrolysate to ameliorate LPS-mediated inflammation and oxidative stress in RAW264.7 macrophages. Molecules 27(24):8816. https://doi.org/10.3390/molecules27248816

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Wang X, Guo X, Wei L, Cui H, Wei Q, Cai J, Zhao Z, Dong J, Wang J, Liu J, Xia Z, Hu Z (2024) Rapid screening of the novel bioactive peptides with notable alpha-glucosidase inhibitory activity by UF-LC-MS/MS combined with three-AI-tool from black beans. Int J Biol Macromol 266(Pt 1):130982. https://doi.org/10.1016/j.ijbiomac.2024.130982

Article  CAS  PubMed  Google Scholar 

Du C, Hui Z, Li N, Liu K, Wang Y, Wang P, Sun S (2024) Investigation of the antioxidative potential of Meretrix meretrix L. derived peptides from simulated gastrointestinal digestion: in vitro and in silico insights. LWT 198:115939. https://doi.org/10.1016/j.lwt.2024.115939

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