Sedeta E, Sung H, Laversanne M, Bray F, Jemal A (2023) Recent mortality patterns and time trends for the major cancers in 47 countries worldwide. Cancer Epidemiol Biomarkers Prev 32:894–905
Han B, Zheng R, Zeng H, Wang S, Sun K, Chen R et al (2024) Cancer incidence and mortality in China, 2022. J Natl Cancer Cent 4:47–53
PubMed PubMed Central Google Scholar
Kim Y, Jang Y, Kim MS, Kang C (2024) Metabolic remodeling in cancer and senescence and its therapeutic implications. Trends Endocrinol Metab 35:744
Yang J, Shay C, Saba NF, Teng Y (2024) Cancer metabolism and carcinogenesis. Exp Hematol Oncol 13:10
Article PubMed PubMed Central Google Scholar
Pavlova NN, Thompson CB (2016) The emerging hallmarks of cancer metabolism. Cell Metab 23(1):27–47
Article CAS PubMed PubMed Central Google Scholar
Xing L et al (2020) A transcriptional metabolic gene-set based prognostic signature is associated with clinical and mutational features in head and neck squamous cell carcinoma. J Cancer Res Clin Oncol 146(3):621–630
Article CAS PubMed PubMed Central Google Scholar
Trajkovic-Arsic M, Subramani E (2023) Is metabolism the magic bullet for targeted cancer therapy? BMC Cancer 23(1):484
Article PubMed PubMed Central Google Scholar
Sirico M, D’Angelo A, Gianni C, Casadei C, Merloni F, De Giorgi U et al (2023) Current state and future challenges for PI3K inhibitors in cancer therapy. Cancers (Basel) 15(3):703
Article CAS PubMed PubMed Central Google Scholar
Goncalves MD, Hopkins BD, Cantley LC (2019) Dietary fat and sugar in promoting cancer development and progression. Annu Rev Cancer Biol 3:255–273
Hopkins BD, Goncalves MD, Cantley LC (2016) Obesity and cancer mechanisms: cancer metabolism. J Clin Oncol 34:4277–4283
Article CAS PubMed PubMed Central Google Scholar
Gallagher EJ, LeRoith D (2020) Hyperinsulinaemia in cancer. Nat Rev Cancer 20:629–644
Article CAS PubMed Google Scholar
Schmidt M, Pfetzer N, Schwab M, Strauss I, Kämmerer U (2011) Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: a pilot trial. Nutr Metab (Lond) 8(1):54
Article CAS PubMed PubMed Central Google Scholar
Bianchi G, Martella R, Ravera S et al (2015) Fasting induces anti‐Warburg effect that increases respiration but reduces ATP‐synthesis to promote apoptosis in colon cancer models. Oncotarget 6:11806–11819
Article PubMed PubMed Central Google Scholar
Di Biase S, Longo VD (2016) Fasting‐induced differential stress sensitization in cancer treatment. Mol Cell Oncol 3:e1117701
Article CAS PubMed Google Scholar
Sadeghian M, Rahmani S, Khalesi S, Hejazi E (2021) A review of fasting effects on the response of cancer to chemotherapy. Clin Nutr 40:1669–1681
Article CAS PubMed Google Scholar
Vernieri C, Ligorio F, Huber V et al (2022) Fasting-mimicking diet is safe and reshapes metabolism and antitumor immunity in patients with cancer. Cancer Discov 12:90–107
Article CAS PubMed Google Scholar
Zhong Z, Zhang H, Nan K et al (2023) Fasting-mimicking diet drives antitumor immunity against colorectal cancer by reducing IgA-producing cells. Cancer Res 83(21):3529–3543
Article CAS PubMed PubMed Central Google Scholar
Caffa I, Spagnolo V, Vernieri C et al (2020) Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature 583(7817):620–624
Article CAS PubMed PubMed Central Google Scholar
Di Tano M, Raucci F, Vernieri C et al (2020) Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun 11(1):2332
Article PubMed PubMed Central Google Scholar
Liu X, Peng S, Tang G et al (2023) Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells. EBioMedicine 90:104496
Article CAS PubMed PubMed Central Google Scholar
Wei M et al (2017) Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med 9:eaal8700
Hammer SS, Vieira CP, McFarland D, Sandler M, Levitsky Y, Dorweiler TF et al (2021) Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction. Diabetologia 64:1674–1689
Article CAS PubMed PubMed Central Google Scholar
de Groot S, Lugtenberg RT, Cohen D, Welters MJP, Ehsan I, Vreeswijk MPG et al (2020) Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat Commun 11:3083
Article PubMed PubMed Central Google Scholar
Huang AW, Wei M, Caputo S, Wilson ML, Antoun J, Hsu WC (2021) An intermittent fasting mimicking nutrition bar extends physiologic ketosis in time restricted eating: a randomized, controlled, parallel-arm study. Nutrients 13(5):1523
Article CAS PubMed PubMed Central Google Scholar
Cortellino S, Raveane A, Chiodoni C et al (2022) Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects. Cell Rep 40:111256
Article CAS PubMed Google Scholar
Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71
Article PubMed PubMed Central Google Scholar
Ferguson JJA, Abbott KA, Garg ML (2021) Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev 79(9):1043–1066
Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol 14:43
Article PubMed PubMed Central Google Scholar
Raucci F, Vernieri C, Di Tano M et al (2024) Cyclic fasting-mimicking diet plus bortezomib and rituximab is an effective treatment for chronic lymphocytic leukemia. Cancer Res 84(7):1133–1148
Article CAS PubMed PubMed Central Google Scholar
Huang W, Li X, Song H, Yin Y, Wang H (2023) Verification of fasting-mimicking diet to assist monotherapy of human cancer-bearing models. Biochem Pharmacol 215:115699
Article CAS PubMed Google Scholar
Nan K, Zhong Z, Yue Y, Shen Y, Zhang H, Wang Z et al (2025) Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8+ T cells. Gut 74(5):775–786
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