Prediction model based on gut microbiota as a non-invasive tool for gastric cancer diagnosis

Bajaj JS, Thacker LR, Fagan A, White MB, Gavis EA, Hylemon PB, Brown R, Acharya C, Heuman DM, Fuchs M, Dalmet S, Sikaroodi M, Gillevet PM (2018) Gut microbial RNA and DNA analysis predicts hospitalizations in cirrhosis. JCI Insight 3:e98019. https://doi.org/10.1172/jci.insight.98019

Article  PubMed  PubMed Central  Google Scholar 

Bouras E, Tsilidis KK, Triggi M, Siargkas A, Chourdakis M, Haidich AB (2022) Diet and risk of gastric cancer: an umbrella review. Nutrients 14:1764. https://doi.org/10.3390/nu14091764

Article  PubMed  PubMed Central  Google Scholar 

Chen C, Chen L, Lin L, Jin D, Du Y, Lyu J (2021) Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer. Appl Microbiol Biotechnol 105:4415–4425. https://doi.org/10.1007/s00253-021-11358-z

Article  CAS  PubMed  Google Scholar 

Chen C, Du Y, Liu Y, Shi Y, Niu Y, Jin G, Shen J, Lyu J, Lin L (2022a) Characteristics of gastric cancer gut microbiome according to tumor stage and age segmentation. Appl Microbiol Biotechnol 106:6671–6687. https://doi.org/10.1007/s00253-022-12156-x

Article  CAS  PubMed  Google Scholar 

Chen C, Shen J, Du Y, Shi X, Niu Y, Jin G, Liu Y, Shi Y, Lyu J, Lin L (2022b) Characteristics of gut microbiota in patients with gastric cancer by surgery, chemotherapy and lymph node metastasis. Clin Transl Oncol 24:2181–1290. https://doi.org/10.1007/s12094-022-02875-y

Article  CAS  PubMed  Google Scholar 

David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature 505:559–563. https://doi.org/10.1038/nature12820

Article  CAS  PubMed  Google Scholar 

Dicks LMT, Geldenhuys J, Mikkelsen LS, Brandsborg E, Marcotte H (2018) Our gut microbiota: a long walk to homeostasis. Benef Microbes 9:3–20. https://doi.org/10.3920/BM2017.0066

Article  CAS  PubMed  Google Scholar 

Gao W, Wang X, Shi Y, Wu G, Zhou M, Lin X (2025) Predictable regulation of gut microbiome in immunotherapeutic efficacy of gastric cancer. Genes Immun 26:1–8. https://doi.org/10.1038/s41435-024-00306-2

Article  CAS  PubMed  Google Scholar 

Gašenko E, Bogdanova I, Sjomina O, Aleksandraviča I, Kiršners A, Ancāns G, Rudzīte D, Vangravs R, Sīviņš A, Škapars R, Tzivian L, Polaka I, Folkmanis V, Leja M (2023) Assessing the utility of pepsinogens and gastrin-17 in gastric cancer detection. Eur J Cancer Prev 32:478–484. https://doi.org/10.1097/CEJ.0000000000000791

Article  CAS  PubMed  Google Scholar 

Gunathilake MN, Lee J, Choi IJ, Kim YI, Ahn Y, Park C, Kim J (2019) Association between the relative abundance of gastric microbiota and the risk of gastric cancer: a case-control study. Sci Rep 9:13589. https://doi.org/10.1038/s41598-019-50054-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halkjær SI, Christensen AH, Lo BZS, Browne PD, Günther S, Hansen LH, Petersen AM (2018) Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study. Gut 67:2107–2115. https://doi.org/10.1136/gutjnl-2018-316434

Article  CAS  PubMed  Google Scholar 

Hartmann P, Chu H, Duan Y, Schnabl B (2019) Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either. Am J Physiol Gastrointest Liver Physiol 316:G563–G573. https://doi.org/10.1152/ajpgi.00370.2018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lehmann T, Schallert K, Vilchez-Vargas R, Benndorf D, Püttker S, Sydor S, Schulz C, Bechmann L, Canbay A, Heidrich B, Reichl U, Link A, Heyer R (2019) Metaproteomics of fecal samples of Crohn’s disease and Ulcerative Colitis. J Proteomics 201:93–103. https://doi.org/10.1016/j.jprot.2019.04.009

Article  CAS  PubMed  Google Scholar 

Liang Y, Wang W, Fang C, Raj SS, Hu WM, Li QW, Zhou ZW (2016) Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer. Oncotarget 7:49565–49573. https://doi.org/10.18632/oncotarget.10391

Article  PubMed  PubMed Central  Google Scholar 

Lin Y, Zheng Y, Wang HL, Wu J (2021) Global patterns and trends in gastric cancer incidence rates (1988–2012) and Predictions to 2030. Gastroenterology 161:116-127.e8. https://doi.org/10.1053/j.gastro.2021.03.023

Article  PubMed  Google Scholar 

Liu F, Li J, Guan Y, Lou Y, Chen H, Xu M, Deng D, Chen J, Ni B, Zhao L, Li H, Sang H, Cai X (2019) Dysbiosis of the gut microbiome is associated with tumor biomarkers in lung cancer. Int J Biol Sci 15:2381–2392. https://doi.org/10.7150/ijbs.35980

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagpal M, Singh S, Singh P, Chauhan P, Zaidi MA (2016) Tumor markers: A diagnostic tool. Natl J Maxillofac Surg 7:17. https://doi.org/10.4103/0975-5950.196135

Article  PubMed  PubMed Central  Google Scholar 

Necula L, Matei L, Dragu D, Neagu AI, Mambet C, Nedeianu S, Bleotu C, Diaconu CC, Chivu-Economescu M (2019) Recent advances in gastric cancer early diagnosis. World J Gastroenterol 25:17. https://doi.org/10.3748/wjg.v25.i17.2029

Article  CAS  Google Scholar 

Parizadeh M, Arrieta MC (2023) The global human gut microbiome: genes, lifestyles, and diet. Trends Mol Med 29:789–801. https://doi.org/10.1016/j.molmed.2023.07.002

Article  PubMed  Google Scholar 

Qi YF, Sun JN, Ren LF, Cao XL, Dong JH, Tao K, Guan XM, Cui YN, Su W (2019) Intestinal microbiota is altered in patients with gastric cancer from Shanxi province, China. Dig Dis Sci 64:1193–1203. https://doi.org/10.1007/s10620-018-5411-y

Article  CAS  PubMed  Google Scholar 

Rawla P, Barsouk A (2019) Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol 14:26–38. https://doi.org/10.5114/pg.2018.80001

Article  CAS  PubMed  Google Scholar 

Shimada H, Noie T, Ohashi M, Oba K, Takahashi Y (2014) Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association. Gastric Cancer 17:26–33. https://doi.org/10.1007/s10120-013-0259-5

Article  CAS  PubMed  Google Scholar 

Shimura T, Dayde D, Wang H, Okuda Y, Iwasaki H, Ebi M, Kitagawa M, Yamada T, Yamada T, Hanash SM, Taguchi A, Kataoka H (2020) Novel urinary protein biomarker panel for early diagnosis of gastric cancer. Br J Cancer 123:1656–1664. https://doi.org/10.1038/s41416-020-01063-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, Wong K, Abrouk M, Farahnik B, Nakamura M, Zhu TH, Bhutani T, Liao W (2017) Influence of diet on the gut microbiome and implications for human health. J Transl Med 15:73. https://doi.org/10.1186/s12967-017-1175-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lee J, Lam KP, Hartman M, Yong WP, Too HP, Yeoh KG (2021) Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population. Gut 70:829–837. https://doi.org/10.1136/gutjnl-2020-322065

Article  CAS  PubMed  Google Scholar 

Thrift AP, El-Serag HB (2020) Burden of gastric cancer. Clin Gastroenterol Hepatol 18:534–542. https://doi.org/10.1016/j.cgh.2019.07.045

Article  PubMed  Google Scholar 

Thrift AP, Wenker TN, El-Serag HB (2023) Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention. Nat Rev Clin Oncol 20:338–349. https://doi.org/10.1038/s41571-023-00747-0

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