In silico analysis of the oncogenic role of myoferlin (MYOF) and suggestion of folate as a potential therapeutic for brain cancer in the Caucasian population

Ludwig K, Kornblum HI. Molecular markers in glioma. J Neurooncol. 2017;134(3):505–12. https://doi.org/10.1007/s11060-017-2379-y. Epub 2017 Feb 23. PMID: 28233083; PMCID: PMC5568999.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreas F, Hottinger KG, Abdullah. Roger Stupp, Chap. 6 - Current Standards of Care in Glioblastoma Therapy, Glioblastoma, Elsevier, 2016, Pages 73–80, ISBN 9780323476607.

Gusev Y, Bhuvaneshwar K, Song L, et al. The REMBRANDT study, a large collection of genomic data from brain cancer patients. Sci Data. 2018;5:180158.

CAS  PubMed  PubMed Central  Google Scholar 

Zhu X, Huang Q, Luo J, Kong D, Zhang Y. Mini-review: gene regulatory network benefits from three-dimensional chromatin conformation and structural biology. Comput Struct Biotechnol J. 2023;21:1728–37. PMID: 36890880; PMCID: PMC9986247.

CAS  PubMed  PubMed Central  Google Scholar 

Ardizzone A, Scuderi SA, Giuffrida D, Colarossi C, Puglisi C, Campolo M, Cuzzocrea S, Esposito E, Paterniti I. Role of fibroblast growth factors receptors (FGFRs) in brain tumors, focus on Astrocytoma and glioblastoma. Cancers. 2020;12(12):3825. https://doi.org/10.3390/cancers12123825.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. 2013;493(7433):537–41. https://doi.org/10.1038/nature11740. Epub 2012 Dec 12. PMID: 23235822; PMCID: PMC4160519.

Article  CAS  PubMed  Google Scholar 

Davis S, Meltzer P. GEOquery: a Bridge between the gene expression omnibus (GEO) and r/bioconductor. Bioinformatics. 2007;23(14):1846–7.

PubMed  Google Scholar 

Schwartz AS, Yu J, Gardenour KR, Finley RL Jr, Ideker T. Cost-effective strategies for completing the interactome. Nat Methods. 2008;6(1):55–61.

PubMed  PubMed Central  Google Scholar 

Szklarczyk D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–13.

CAS  PubMed  Google Scholar 

Opeyemi Iwaloye PO, Ottu F, Olawale OO, Babalola OO, Elekofehinti. Babatomiwa Kikiowo, Abayomi Emmanuel Adegboyega, Henry Nnaemeka Ogbonna, Covenant Femi Adeboboye, Ibukun Mary Folorunso, Aderonke Elizabeth Fakayode, Moses Orimoloye Akinjiyan, Sunday Amos Onikanni, Sergey Shityakov, Computer-aided drug design in anti-cancer drug discovery: What have we learnt and what is the way forward? Informatics in Medicine Unlocked, Volume 41, 2023, 101332, ISSN 2352–9148.

Eberhardt J, Santos-Martins D, Tillack AF, Forli S. AutoDock Vina 1.2.0: new Docking methods, expanded force field, and Python bindings. Journal of Chemical Information and Modeling; 2021.

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE. The protein data bank. Nucleic Acids Res. 2000;28(1):235–42. https://doi.org/10.1093/nar/28.1.235. PMID: 10592235; PMCID: PMC102472.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan S, Chan HC, Stephen. Hu, Zhenquan, C7 - e1298, TI - Using PyMOL as a platform for computational drug design, WIREs Computational Molecular Science, WIREs Comput Mol Sci.

Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, Wang J, Yu B, Zhang J, Bryant SH. PubChem substance and compound databases. Nucleic Acids Res. 2016;44(D1):D1202–13. https://doi.org/10.1093/nar/gkv951. Epub 2015 Sep 22. PMID: 26400175; PMCID: PMC4702940.

Article  CAS  PubMed  Google Scholar 

Martín Abadi A, Agarwal P, Barham E, Brevdo Z, Chen C, Citro GS, Corrado A, Davis J, Dean M, Devin S, Ghemawat I, Goodfellow A, Harp G, Irving M, Isard. Rafal jozefowicz, Yangqing jia, Lukasz kaiser, Manjunath kudlur, Josh levenberg, Dan Mané. Mike schuster, Rajat monga, Sherry moore, Derek murray, Chris olah, Jonathon shlens, Benoit steiner, Ilya sutskever, Kunal talwar, Paul tucker, Vincent vanhoucke, Vijay vasudevan, Fernanda viégas, oriol vinyals, Pete warden, Martin wattenberg, Martin wicke, Yuan yu, and Xiaoqiang Zheng. Tensor Flow: Large-scale machine learning on heterogeneous systems; 2015.

Khan I, Steeg PS. Endocytosis: a pivotal pathway for regulating metastasis. Br J Cancer, 2021.

Robles-Remacho A, Sanchez-Martin RM, Diaz-Mochon JJ. Spatial transcriptomics: emerging technologies in tissue gene expression profiling. Anal Chem. 2023;95(42):15450–60. https://doi.org/10.1021/acs.analchem.3c02029. Epub 2023 Oct 10. PMID: 37814884; PMCID: PMC10603609.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Jiang Y, Zhang Y, Zhu H. Medical image analysis using deep learning algorithms. Front Public Health. 2023;11:1273253. https://doi.org/10.3389/fpubh.2023.1273253. PMID: 38026291; PMCID: PMC10662291.

Article  PubMed  PubMed Central  Google Scholar 

http://www.spatialomics.org/SpatialDB/lcm_27387371_browse.php?gene=MYOF&species=human&log=none

Baba AB, Rah B, Bhat GR, Mushtaq I, Parveen S, Hassan R, Hameed Zargar M, Afroze D. Transforming growth Factor-Beta (TGF-β) signaling in Cancer-A betrayal within. Front Pharmacol. 2022;13:791272. https://doi.org/10.3389/fphar.2022.791272. PMID: 35295334; PMCID: PMC8918694.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mason JB, Dickstein A, Jacques PF, et al. A Temporal association between folic acid fortification and an increase in colorectal cancer rates May be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev. 2007;16(7):1325.

CAS  PubMed  Google Scholar 

https://www.mhanational.org/folate#:~:text=Folate%20is%20especially%20promising%20for,supplements%20are%20a%20prudent%20neuroprotectant.

Menezo Y, Elder K, Clement A, Clement P, Folic, Acid. Folinic acid, 5 Methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and One-Carbon cycles. Biomolecules. 2022;12(2):197. https://doi.org/10.3390/biom12020197.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kapoor M, Gupta V. Astrocytoma. [Updated 2024 May 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559042/

Morris GM, Lim-Wilby M. Molecular docking. Methods Mol Biol. 2008;443:365– 82. https://doi.org/10.1007/978-1-59745-177-2_19. PMID: 18446297.

Kobayashi K. Role of catecholamine signaling in brain and nervous system functions: new insights from mouse molecular genetic study. J Investig Dermatol Symp Proc. 2001;6(1):115– 21. https://doi.org/10.1046/j.0022-202x.2001.00011.x. PMID: 11764279.

Dalangin R, Kim A, Campbell RE. The role of amino acids in neurotransmission and fluorescent tools for their detection. Int J Mol Sci. 2020;21(17):6197. https://doi.org/10.3390/ijms21176197.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taddei ML, Pardella E, Pranzini E, Raugei G, Paoli P. Role of tyrosine phosphorylation in modulating cancer cell metabolism, biochimica et biophysica acta (BBA) - Reviews on Cancer, 1874, 2020, https://doi.org/10.1016/j.bbcan.2020.188442

Moon L-M, Thapliyal N, Hussain KK, Goyal RN, Shim Y-B. Conducting polymer-based electrochemical biosensors for neurotransmitters: A review, biosensors and bioelectronics, 102, 2018, Pages 540–52, https://doi.org/10.1016/j.bios.2017.11.069

Bryant J, Jongkees B, Hommel S, Kühn LS, Colzato. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. J Psychiatr Res. 2015;70:50–7. https://doi.org/10.1016/j.jpsychires.2015.08.014.

Article  Google Scholar 

Cui Wenqiang A, Adnane W, Shouguo Y, Qiuliyang L, Yanhua. Yuan shuguang, discovering Anti-Cancer drugs via computational methods, frontiers in Pharmacology, 11, 2020.

McGarel C, Pentieva K, Strain JJ, McNulty H. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc. 2015;74(1):46–55. Epub 2014 Nov 5. PMID: 25371067.

CAS  PubMed  Google Scholar 

Zheng Y, Cantley LC. Toward a better Understanding of folate metabolism in health and disease. J Exp Med. 2019;216(2):253–66. https://doi.org/10.1084/jem.20181965. Epub 2018 Dec 26. PMID: 30587505; PMCID: PMC6363433.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif