Vargason AM, Anselmo AC, Mitragotri S. The evolution of commercial drug delivery technologies. Nat Biomed Eng. 2021;5(9):951–67. https://doi.org/10.1038/s41551-021-00698-w.
Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965;13(1):238–52. https://doi.org/10.1016/s0022-2836(65)80093-6.
Article CAS PubMed Google Scholar
https://pmc.ncbi.nlm.nih.gov/. Accessed January 16, 2025
https://www.britannica.com/science/nanomedicine
Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33(9):941–51. https://doi.org/10.1038/nbt.3330.
Article CAS PubMed PubMed Central Google Scholar
https://www.cancer.gov/nano/research/nclhttps://www.euncl.org/
https://www.lne.fr/fr/evenements/workshop-nanomedicine
Halwani AA. Development of pharmaceutical nanomedicines: from the bench to the market. Pharmaceutics. 2022;14(1):106. https://doi.org/10.3390/pharmaceutics14010106.
Article CAS PubMed PubMed Central Google Scholar
https://www.precedenceresearch.com/nanomedicine-market. Accessed January 16, 2025
https://www.statista.com/outlook/hmo/pharmaceuticals/vaccines/covid-19-vaccines/worldwide. Accessed January 16, 2025
Lankheet S, Kampkuiper N, Nellensteijn J, Hekman E, Tuijthof G, Schröder F, Koenrades M. Sacroiliac joint fusion guided by intraoperatively superimposed virtual surgical planning using simulated fluoroscopic images. Brain Spine. 2024;4:102905. https://doi.org/10.1016/j.bas.2024.102905.
Article PubMed PubMed Central Google Scholar
Metselaar JM, Lammers T. Challenges in nanomedicine clinical translation. Drug Deliv Transl Res. 2020;10(3):721–5. https://doi.org/10.1007/s13346-020-00740-5.
Article PubMed PubMed Central Google Scholar
Soga O, van Nostrum CF, Hennink WE. Poly(N-(2-hydroxypropyl) methacrylamide Mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity. Biomacromolecules. 2004 May-Jun;5(3):818–21. https://doi.org/10.1021/bm049955q.
Rijcken CJ, Snel CJ, Schiffelers RM, van Nostrum CF, Hennink WE. Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials. 2007;28(36):5581–93. https://doi.org/10.1016/j.biomaterials.2007.08.047.
Crielaard BJ, Rijcken CJ, Quan L, van der Wal S, Altintas I, van der Pot M, Kruijtzer JA, Liskamp RM, Schiffelers RM, van Nostrum CF, Hennink WE, Wang D, Lammers T, Storm G. Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angew Chem Int Ed Engl. 2012;51(29):7254–8. https://doi.org/10.1002/anie.201202713.
Article CAS PubMed PubMed Central Google Scholar
Talelli M, Barz M, Rijcken CJ, Kiessling F, Hennink WE, Lammers T. Core-Crosslinked polymeric micelles: principles, preparation, biomedical applications and clinical translation. Nano Today. 2015;10(1):93–117. https://doi.org/10.1016/j.nantod.2015.01.005.
Article CAS PubMed PubMed Central Google Scholar
Hu Q, Rijcken CJ, Bansal R, Hennink WE, Storm G, Prakash J. Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles. Biomaterials. 2015;53:370–8. https://doi.org/10.1016/j.biomaterials.2015.02.085.
Article CAS PubMed Google Scholar
Rijcken CJF, De Lorenzi F, Biancacci I, Hanssen RGJM, Thewissen M, Hu Q, Atrafi F, Liskamp RMJ, Mathijssen RHJ, Miedema IHC, Menke-van der Houven van Oordt CW, van Dongen GAMS, Vugts DJ, Timmers M, Hennink WE, Lammers T. Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles. Adv Drug Deliv Rev. 2022;191:114613. https://doi.org/10.1016/j.addr.2022.114613
Atrafi F, Dumez H, Mathijssen RHJ, van der Menke CW, Rijcken CJF, Hanssen R, Eskens FALM, Schöffski P. A phase I dose-escalation and Pharmacokinetic study of a micellar nanoparticle with entrapped docetaxel (CPC634) in patients with advanced solid tumours. J Control Release. 2020;325:191–7. https://doi.org/10.1016/j.jconrel.2020.06.020.
Article CAS PubMed Google Scholar
Miedema IHC, Zwezerijnen GJC, Huisman MC, Doeleman E, Mathijssen RHJ, Lammers T, Hu Q, van Dongen GAMS, Rijcken CJF, Vugts DJ. Menke-van der Houven Van oordt CW. PET-CT imaging of polymeric nanoparticle tumor accumulation in patients. Adv Mater. 2022;34(21):e2201043. https://doi.org/10.1002/adma.202201043.
Article CAS PubMed Google Scholar
Gonda K, Negishi H, Takano-Kasuya M, Kitamura N, Furusawa N, Nakano Y, Hamada Y, Tokunaga M, Higuchi H, Tada H, Ishida T. Heterogeneous drug efficacy of an Antibody-Drug conjugate visualized using simultaneous imaging of its delivery and intracellular damage in living tumor tissues. Transl Oncol. 2020;13(6):100764. https://doi.org/10.1016/j.tranon.2020.100764.
Article PubMed PubMed Central Google Scholar
van Dongen GAMS. Improving tumor penetration of antibodies and Antibody-Drug conjugates: taking away the barriers for Trojan horses. Cancer Res. 2021;81(15):3956–7. https://doi.org/10.1158/0008-5472.
Marusyk A, Janiszewska M, Polyak K. Intratumor heterogeneity: the Rosetta stone of therapy resistance. Cancer Cell. 2020;37(4):471–84. https://doi.org/10.1016/j.ccell.2020.03.007.
Article CAS PubMed PubMed Central Google Scholar
Duncan KD, Pětrošová H, Lum JJ, Goodlett DR. Mass spectrometry imaging methods for visualizing tumor heterogeneity. Curr Opin Biotechnol. 2024;86:103068. https://doi.org/10.1016/j.copbio.2024.103068.
Article CAS PubMed PubMed Central Google Scholar
Atrafi F, van Eerden RAG, van Hylckama Vlieg MAM, Oomen-de Hoop E, de Bruijn P, Lolkema MP, Moelker A, Rijcken CJ, Hanssen R, Sparreboom A, Eskens FALM, Mathijssen RHJ, Koolen SLW. Intratumoral comparison of nanoparticle entrapped docetaxel (CPC634) with conventional docetaxel in patients with solid tumors. Clin Cancer Res. 2020;26(14):3537–45. https://doi.org/10.1158/1078-0432.CCR-20-0008.
Article CAS PubMed Google Scholar
Atrafi F, van Eerden RAG, Koolen SLW, de Bruijn P, Rijcken CJF, Hanssen R, Eskens FALM, Lolkema MP, Oomen-de Hoop E, Damman J, Mathijssen RHJ. Docetaxel skin exposure and micronucleation contributes to skin toxicity caused by CPC634. Cancers (Basel). 2021;13(15):3741. https://doi.org/10.3390/cancers13153741.
Article CAS PubMed Google Scholar
Bissery MC, Nohynek G, Sanderink GJ, Lavelle F. Docetaxel (Taxotere): a review of preclinical and clinical experience. Part I: preclinical experience. Anticancer Drugs. 1995;6(3):339–55. https://doi.org/10.1097/00001813-199506000-00001.
Article CAS PubMed Google Scholar
Rosing H, Lustig V, van Warmerdam LJ, Huizing MT, ten Bokkel Huinink WW, Schellens JH, Rodenhuis S, Bult A, Beijnen JH. Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion. Cancer Chemother Pharmacol. 2000;45(3):213–8. https://doi.org/10.1007/s002800050032.
Article CAS PubMed Google Scholar
Boere I, Vergote I, Hanssen R, Jalving M, Gennigens C, Ottevanger P, van de Wouw YJ, Rijcken CJF, Mathijssen RHJ, Ledermann J. CINOVA: a phase II study of CPC634 (nanoparticulate docetaxel) in patients with platinum resistant recurrent ovarian cancer. Int J Gynecol Cancer. 2023;33(8):1247–52. https://doi.org/10.1136/ijgc-2023-004308.
Von Hoff DD, Mita MM, Ramanathan RK, Weiss GJ, Mita AC, LoRusso PM, Burris HA 3rd, Hart LL, Low SC, Parsons DM, Zale SE, Summa JM, Youssoufian H, Sachdev JC. Phase I study of PSMA-Targeted Docetaxel-Containing nanoparticle BIND-014 in patients with advanced solid tumors. Clin Cancer Res. 2016;22(13):3157–63. https://doi.org/10.1158/1078-0432.CCR-15-2548.
https://starpharma.com/news/view/750/positive-dep-docetaxel-phase-2-results-asx-announcement
van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, van der Hoeven JJ, Windhorst AD, Lammertsma AA, Lubberink M. Biodistribution and radiation dosimetry of 11 C-labelled docetaxel in cancer patients. Eur J Nucl Med Mol Imaging. 2010;37(10):1950–8. https://doi.org/10.1007/s00259-010-1489-y.
Article CAS PubMed PubMed Central Google Scholar
https://www.linkedin.com/posts/simonbl_probabilityofsuccess-ptrs-pos-activity-7274695863514390528-JESq
https://www.norstella.com/why-clinical-development-success-rates-falling
Mellman I, Chen DS, Powles T, Turley SJ. The cancer-immunity cycle: indication, genotype, and immunotype. Immunity. 2023;56(10):2188–205. https://doi.org/10.1016/j.immuni.2023.09.011.
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