Murakami S, Mealey BL, Mariotti A, Chapple IL. Dental plaque–induced gingival conditions. J Clin Periodontol. 2018;45(20):S17–27. https://doi.org/10.1111/jcpe.12937.

Article  CAS  PubMed  Google Scholar 

Khabadze Z, Kulikova A, Generalova Y, Abdulkerimova S, Dashtieva M, Bakaev Y, Kubrin A. The prevalence of inflammatory periodontal diseases (Gingivitis, Periodontitis) among the population. J Int Dent Med Res. 2003;16(4):1830–5.

Google Scholar 

Al-Shammari KF, Al‐Khabbaz AK, Al‐Ansari JM, Neiva R, Wang HL. Risk indicators for tooth loss due to periodontal disease. J Periodont. 2005;76(11):1910–8. https://doi.org/10.2147/cia.s140791.

Article  PubMed  Google Scholar 

Kim S, Kim SG. Advancements in alveolar bone grafting and ridge preservation: a narrative review on materials, techniques, and clinical outcomes. Maxillofac Plast Reconstr Sur. 2024;46(14):1–13. https://doi.org/10.1186/s40902-024-00425-w.

Article  CAS  Google Scholar 

Kuć J, Sierpińska T, Gołębiewska M. Alveolar ridge atrophy related to facial morphology in edentulous patients. Clin Interv Aging. 2017;12:1481–94. https://doi.org/10.2147/cia.s140791.

Article  PubMed  PubMed Central  Google Scholar 

Devlin H, Ferguson M. Alveolar ridge resorption and mandibular atrophy. A review of the role of local and systemic factors. Br Dent J. 1991;170:101–4. https://doi.org/10.1038/sj.bdj.4807427.

Article  CAS  PubMed  Google Scholar 

Zakrzewski W, Dobrzynski M, Rybak Z, Szymonowicz M, Wiglusz RJ. Selected nanomaterials’ application enhanced with the use of stem cells in acceleration of alveolar bone regeneration during augmentation process. Nanomaterials. 2020;10(6):1216. https://doi.org/10.3390/nano10061216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuchida S, Nakayama T. Recent clinical treatment and basic research on the alveolar bone. Biomedicines. 2023;11(3):843. https://doi.org/10.3390/biomedicines11030843.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giannobile WV, Berglundh T, Al-Nawas B, Araujo M, Bartold PM, Bouchard P, Chapple I, Gruber R, Lundberg P, Sculean A. Biological factors involved in alveolar bone regeneration: consensus report of working group 1 of the 15th European workshop on periodontology on bone regeneration. J Clin Periodontol. 2019;46(21):6–11. https://doi.org/10.1111/jcpe.13130.

Article  PubMed  Google Scholar 

Jafary F, Hanachi P, Gorjipour K. Osteoblast differentiation on collagen scaffold with immobilized alkaline phosphatase. Int J Organ Transpl Med. 2017;8(4):195–202.

CAS  Google Scholar 

Mikami Y, Lee M, Irie S, Honda MJ. Dexamethasone modulates osteogenesis and adipogenesis with regulation of Osterix expression in rat calvaria-derived cells. J Cell Physiol. 2011;226(3):739–48. https://doi.org/10.1002/jcp.22390.

Article  CAS  PubMed  Google Scholar 

Chen Y, Li J, Kawazoe N, Chen G. Preparation of dexamethasone-loaded calcium phosphate nanoparticles for the osteogenic differentiation of human mesenchymal stem cells. J Mat Chem B. 2017;5(33):6801–10. https://doi.org/10.1039/c7tb01727h.

Article  CAS  Google Scholar 

Salvi G, Lang N. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Curr Pharm Des. 2005;11(14):1757–69. https://doi.org/10.2174/1381612053764878.

Article  CAS  PubMed  Google Scholar 

Howell T, Jeffcoat M, Goldhaber P, Reddy M, Kaplan M, Johnson H, Hall C, Williams R. Inhibition of alveolar bone loss in Beagles with the NSAID Naproxen. J Periodont Res. 1991;26(6):498–501. https://doi.org/10.1111/j.1600-0765.1991.tb01801.x.

Article  CAS  Google Scholar 

Li QY, Zhang JN, Chen BZ, Wang QL, Guo XD. A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin. RSC Adv. 2017;7(28):15408–15. https://doi.org/10.1039/C6RA26759A.

Article  CAS  Google Scholar 

Samanthula KS, Satla SR, Bairi AG. Bioadhesive polymers, permeation enhancers and types of dosage forms for buccal drug delivery. J Drug Deliv Ther. 2021;11(4):138–45. https://doi.org/10.22270/jddt.v11i1.4495.

Article  CAS  Google Scholar 

Caffarel-Salvador E, Kim S, Soares V, Tian RY, Stern SR, Minahan D, Yona R, Lu X, Zakaria FR, Collins J, Wainer J, Wong J, McManus R, Tamang S, McDonnell S, Ishida K, Hayward A, Liu X, Hubálek F, Fels J, Vegge A, Frederiksen MR, Rahbek U, Yoshitake T, Fujimoto J, Roxhed N, Langer R, Traverso G. A microneedle platform for buccal macromolecule delivery. Sci Adv. 2021;7(4):eabe2620. https://doi.org/10.1126/sciadv.abe2620. PMID: 33523951; PMCID: PMC10964974.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khairiyah K, Asaf MB, Achmad NAA, et al. Enhancing Efavirenz bioavailability via Polymer-Based buccal administration: optimization and characterization of Nanocrystal-Loaded dissolving microneedle delivery systems. AAPS J. 2025;27:64. https://doi.org/10.1208/s12248-025-01047-4.

Article  CAS  PubMed  Google Scholar 

Cao X, Wu B, Chen J, Liu Z, Yang Y, Li S, Huang H. Hydroxypropyl Cellulose-Based orally dissolving film loaded with insoluble dexamethasone for treatment of oral ulcers. Mol Pharm. 2024;21(8):4012–23.

Article  CAS  PubMed  Google Scholar 

Hassan MA, Barakat NS, El-Badry M, Shehata SM. Formulation and in vitro/in vivo evaluation of Naproxen mucoadhesive buccal patches for local effect. J Drug Deliv Sci Technol. 2021;21(5):423.

Article  Google Scholar 

Harvey AJ, Kaestner SA, Sutter DE, Harvey NG, Mikszta JA, Pettis RJ. Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs. Pharm Res. 2011;28(1):107–16. https://doi.org/10.1007/s11095-010-0123-9.

Article  CAS  PubMed  Google Scholar 

Li Y, Bi D, Hu Z, Yang Y, Liu Y, Leung WK. Hydrogel-forming microneedles with applications in oral diseases management. Mater. 2023;16(13):4805.

Article  CAS  Google Scholar 

Giuliano E, Paolino D, Fresta M, Cosco D. Drug-loaded biocompatible nanocarriers embedded in poloxamer 407 hydrogels as therapeutic formulations. Medicines. 2018;6(1):7. https://doi.org/10.3390/medicines6010007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Lee JH, Meng M, Cui N, Dai CY, Jia Q, Lee ES, Jiang HB. An overview on thermosensitive oral gel based on poloxamer 407. Materials. 2021;14(18):4522. https://doi.org/10.3390/ma14164522.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sivaraman A, Banga AK. Novel in situ forming hydrogel microneedles for transdermal drug delivery. Drug Deliv Transl Res. 2017;7:16–26.

Article  CAS  PubMed  Google Scholar 

Dew N, Edwards K, Eriksson J, Edsman K, Björk E. Gel formulations containing catanionic vesicles composed of Alprenolol and SDS: effects of drug release and skin penetration on aggregate structure. Colloids Surf B Biointerfaces. 2012;89:53–60. https://doi.org/10.1016/j.colsurfb.2011.08.022.

Article  CAS  PubMed  Google Scholar 

Hirun N, Tantishaiyakul V, Sangfai T, Boonlai W, Soontaranon S, Rugmai S. The effect of poly(acrylic acid) on temperature-dependent behaviors and structural evolution of poloxamer 407. Polym Int. 2021;70(10):1282–9. https://doi.org/10.1002/pi.6197.

Article  CAS  Google Scholar 

Baloglu E, Karavana SY, Senyigit ZA, Hilmioglu-Polat S, Metin DY, Zekioglu O, Guneri T, Jones DS. In-situ gel formulations of econazole nitrate: Preparation and in-vitro and in-vivo evaluation. J Pharm Pharmacol. 2011;63(10):1274–82.

Article  CAS  PubMed  Google Scholar 

Chen J, Zhou R, Li L, Li B, Zhang X, Su J. Mechanical, rheological and release behaviors of a poloxamer 407/poloxamer 188/carbopol 940 thermosensitive composite hydrogel. Molecules. 2013;18(10):12415–25. https://doi.org/10.3390/molecules181012415.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fathalla ZM, Khaled KA, Hussein AK, Alany RG, Vangala A. Formulation and corneal permeation of ketorolac tromet