Almagro Armenteros JJ, Tsirigos KD, Sønderby CK, Petersen TN, Winther O, Brunak S, von Heijne G, Nielsen H (2019) SignalP 5.0 improves signal peptide predictions using deep neural networks. Nat Biotechnol 37:420–423. https://doi.org/10.1038/S41587-019-0036-Z
Article PubMed CAS Google Scholar
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403–410. https://doi.org/10.1016/S0022-2836(05)80360-2
Article PubMed CAS Google Scholar
Awodi UR, Ronan JL, Masschelein J, De Los Santos ELC, Challis GL (2016) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chem Sci 8. https://doi.org/10.1039/c6sc02803a
Bednarz B, Kotowska M, Pawlik KJ (2019) Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2). Appl Microbiol Biotechnol 103:6423–6434. https://doi.org/10.1007/s00253-019-09975-w
Article PubMed PubMed Central CAS Google Scholar
Bednarz B, Millan-Oropeza A, Kotowska M, Świat M, Quispe Haro JJ, Henry C, Pawlik K (2021) Coelimycin Synthesis Activatory Proteins Are Key Regulators of Specialized Metabolism and Precursor Flux in Streptomyces coelicolor A3(2). Front Microbiol 12. https://doi.org/10.3389/FMICB.2021.616050
Chater KF, Biró S, Lee KJ, Palmer T, Schrempf H (2010) The complex extracellular biology of Streptomyces. FEMS Microbiol Rev 34:171–198. https://doi.org/10.1111/J.1574-6976.2009.00206.X
Article PubMed CAS Google Scholar
Drew D, North RA, Nagarathinam K, Tanabe M (2021) Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS). Chem Rev 121:5289–5335. https://doi.org/10.1021/ACS.CHEMREV.0C00983
Article PubMed PubMed Central CAS Google Scholar
Getsin I, Nalbandian GH, Yee DC, Vastermark A, Paparoditis PCG, Reddy VS, Saier MH (2013) Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor. BMC Microbiol 13. https://doi.org/10.1186/1471-2180-13-279
Gomez-Escribano JP, Song L, Fox DJ, Yeo V, Bibb MJ, Challis GL (2012) Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145. Chem Sci 3:2716–2720. https://doi.org/10.1039/C2SC20410J
Gottelt M, Kol S, Gomez-Escribano JP, Bibb M, Takano E (2010) Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). Microbiology (n y) 156:2343–2353. https://doi.org/10.1099/mic.0.038281-0
Gust B, Chandra G, Jakimowicz D, Yuqing T, Bruton CJ, Chater KF (2004) λ Red-Mediated Genetic Manipulation of Antibiotic-Producing Streptomyces. Adv Appl Microbiol 54:107–128. https://doi.org/10.1016/S0065-2164(04)54004-2
Article PubMed CAS Google Scholar
Hassan KA, Skurray RA, Brown MH (2007) Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket. J Bacteriol 189:9131–9135. https://doi.org/10.1128/JB.01492-07
Article PubMed PubMed Central CAS Google Scholar
Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA (2000) Practical Streptomyces Genetics. John Innes Centre Ltd. 529
Kotowska M, Ciekot J, Pawlik K (2014) Type II thioesterase ScoT is required for coelimycin production by the modular polyketide synthase Cpk of Streptomyces coelicolor A3(2). Acta Biochim Pol 61:141–147. https://doi.org/10.18388/ABP.2014_1936
Kumar S, Lekshmi M, Parvathi A, Ojha M, Wenzel N, Varela MF (2020) Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps. Microorganisms 8. https://doi.org/10.3390/MICROORGANISMS8020266
Kutas P, Feckova L, Rehakova A, Novakova R, Homerova D, Mingyar E, Rezuchova B, Sevcikova B, Kormanec J (2013) Strict control of auricin production in Streptomyces aureofaciens CCM 3239 involves a feedback mechanism. Appl Microbiol Biotechnol 97:2413–2421. https://doi.org/10.1007/s00253-012-4505-2
Article PubMed CAS Google Scholar
Letunic I, Bork P (2021) Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Nucleic Acids Res 49:W293–W296. https://doi.org/10.1093/NAR/GKAB301
Article PubMed PubMed Central CAS Google Scholar
Li J, Li Y, Niu G, Guo H, Qiu Y, Lin Z, Liu W, Tan H (2018) NosP-Regulated Nosiheptide Production Responds to Both Peptidyl and Small-Molecule Ligands Derived from the Precursor Peptide. Cell Chem Biol 25:143-153.e4. https://doi.org/10.1016/j.chembiol.2017.10.012
Article PubMed CAS Google Scholar
Li Q, Wang L, Xie Y, Wang S, Chen R, Hong B (2013) SsaA, a member of a novel class of transcriptional regulators, controls sansanmycin production in Streptomyces sp. strain SS through a feedback mechanism. J Bacteriol 195:2232–2243. https://doi.org/10.1128/JB.00054-13
Article PubMed PubMed Central CAS Google Scholar
Li X, Yu T, He Q, McDowall KJ, Jiang B, Jiang Z, Wu L, Li G, Li Q, Wang S, Shi Y, Wang L, Hong B (2015) Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus. Mol Microbiol 96:1257–1271. https://doi.org/10.1111/mmi.13004
Article PubMed CAS Google Scholar
Lorca GL, Barabote RD, Zlotopolski V, Tran C, Winnen B, Hvorup RN, Stonestrom AJ, Nguyen E, Huang LW, Kim DS, Saier MH (2007) Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim Biophys Acta 1768:1342–1366. https://doi.org/10.1016/J.BBAMEM.2007.02.007
Article PubMed PubMed Central CAS Google Scholar
Ma SY, Xiao YS, Zhang B, Shao FL, Guo ZK, Zhang JJ, Jiao RH, Sun Y, Xu Q, Tan RX, Ge HM (2017) Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete. Org Lett 19:6208–6211. https://doi.org/10.1021/ACS.ORGLETT.7B03113/SUPPL_FILE/OL7B03113_SI_001.PDF
Article PubMed CAS Google Scholar
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, De Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJN, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, Van Der Donk WA, Dorrestein PC, Doyle S, Driessen AJM, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O’Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, Van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol 11:625–631. https://doi.org/10.1038/NCHEMBIO.1890
Article PubMed PubMed Central CAS Google Scholar
Nag A, Mehra S (2021) A Major Facilitator Superfamily (MFS) Efflux Pump, SCO4121, from Streptomyces coelicolor with Roles in Multidrug Resistance and Oxidative Stress Tolerance and Its Regulation by a MarR Regulator. Appl Environ Microbiol 87:1–23. https://doi.org/10.1128/AEM.02238-20
Nett M, Moore BS (2009) Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica. In: Pure and Applied Chemistry. pp 1075–1084
Nieselt K, Battke F, Herbig A, Bruheim P, Wentzel A, Jakobsen ØM, Sletta H, Alam MT, Merlo ME, Moore J, Omara WAM, Morrissey ER, Juarez-Hermosillo MA, Rodríguez-García A, Nentwich M, Thomas L, Iqbal M, Legaie R, Gaze WH, Challis GL, Jansen RC, Dijkhuizen L, Rand DA, Wild DL, Bonin M, Reuther J, Wohlleben W, Smith MCM, Burroughs NJ, Martín JF, Hodgson DA, Takano E, Breitling R, Ellingsen TE, Wellington EMH (2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics 11. https://doi.org/10.1186/1471-2164-11-10
Paulsen IT, Brown MH, Littlejohn TG, Mitchell BA, Skurray RA (1996a) Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Proc Natl Acad Sci U S A 93:3630. https://doi.org/10.1073/PNAS.93.8.3630
Article PubMed PubMed Central CAS Google Scholar
Paulsen IT, Brown MH, Skurray RA (1996b) Proton-dependent multidrug efflux systems. Microbiol Rev 60:575–608. https://doi.org/10.1128/MR.60.4.575-608.1996
Article PubMed PubMed Central CAS Google Scholar
Pawlik K, Kotowska M, Chater KF, Kuczek K, Takano E (2007) A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2). Arch Microbiol 187:87–99. https://doi.org/10.1007/S00203-006-0176-7/FIGURES/3
Article PubMed CAS Google Scholar
Pawlik K, Kotowska M, Kolesiński P (2010) Streptomyces coelicolor A3(2) Produces a New Yellow Pigment Associated with the Polyketide Synthase Cpk. Microb Physiol 19:147–151. https://doi.org/10.1159/000321501
Saier MH, Reddy VS, Moreno-Hagelsieb G, Hendargo KJ, Zhang Y, Iddamsetty V, Lam KJK, Tian N, Russum S, Wang J, Medrano-Soto A (2021) The Transporter Classification Database (TCDB): 2021 update. Nucleic Acids Res 49:D461–D467. https://doi.org/10.1093/NAR/GKAA1004
Comments (0)