Hoyte FCL, Nelson HS. Recent advances in allergic rhinitis. F1000Res. 2018;7. https://doi.org/10.12688/f1000research.15367.1.

Meng Y, Wang C, Zhang L. Recent developments and highlights in allergic rhinitis. Allergy. 2019;74(12):2320–8. https://doi.org/10.1111/all.14067.

Article  PubMed  Google Scholar 

Ciprandi G, De Amici M, Murdaca G, Fenoglio D, Ricciardolo F, Marseglia G, et al. Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. Allergy. 2009;64(9):1375–8. https://doi.org/10.1111/j.1398-9995.2009.02010.x.

Article  CAS  PubMed  Google Scholar 

Pilette C, Jacobson MR, Ratajczak C, Detry B, Banfield G, VanSnick J, et al. Aberrant dendritic cell function conditions Th2-cell polarization in allergic rhinitis. Allergy. 2013;68(3):312–21. https://doi.org/10.1111/all.12090.

Article  CAS  PubMed  Google Scholar 

Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor-beta ‘reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol. 2008;9(12):1341–6. https://doi.org/10.1038/ni.1659.

Article  CAS  PubMed  Google Scholar 

Angkasekwinai P. Th9 cells in allergic Disease. Curr Allergy Asthma Rep. 2019;19(5):29. https://doi.org/10.1007/s11882-019-0860-8.

Article  PubMed  Google Scholar 

Kaplan MH, Hufford MM, Olson MR. The development and in vivo function of T helper 9 cells. Nat Rev Immunol. 2015;15(5):295–307. https://doi.org/10.1038/nri3824.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated Colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol. 2014;15(7):676–86. https://doi.org/10.1038/ni.2920.

Article  CAS  PubMed  Google Scholar 

Wang XQ, Hu GH, Kang HY, Shen Y, Ke X, Hong SL. High frequency of T helper type 9 cells in Chinese patients with allergic rhinitis. Asian Pac J Allergy Immunol. 2015;33(4):301–7. https://doi.org/10.12932/AP0609.33.4.2015.

Article  CAS  PubMed  Google Scholar 

Jiang X, Zhang X, Liu J, Liu J, Zhu X, Yang C. Involvement of T-Helper 9 activation in a mouse model of allergic Rhinitis. Med Sci Monit. 2018;24:4704–10. https://doi.org/10.12659/MSM.908302.

Article  CAS  PubMed  Google Scholar 

Li L, Deng J, Huang T, Liu K, Jiang X, Chen X, et al. IRF4 transcriptionally activate HOTAIRM1, which in turn regulates IRF4 expression, thereby affecting Th9 cell differentiation and involved in allergic rhinitis. Gene. 2022;813:146118. https://doi.org/10.1016/j.gene.2021.146118.

Article  CAS  PubMed  Google Scholar 

DiStefano JK. The emerging role of long noncoding RNAs in Human Disease. Methods Mol Biol. 2018;1706:91–110. https://doi.org/10.1007/978-1-4939-7471-9_6.

Article  CAS  PubMed  Google Scholar 

Wei X, Xu M, Wang C, Fang S, Zhang Y, Wang W. Genome-wide analysis of long noncoding RNA expression profile in nasal mucosa with allergic rhinitis. BMC Med Genomics. 2021;14(1):100. https://doi.org/10.1186/s12920-021-00949-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bu WJ, Fang Z, Li WL, Wang X, Dong MJ, Tao QY, et al. LINC00240 sponges miR-4465 to promote proliferation, migration, and invasion of hepatocellular carcinoma cells via HGF/c-MET signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24(20):10452–61. https://doi.org/10.26355/eurrev_202010_23397.

Article  PubMed  Google Scholar 

Zhang Y, Li X, Zhang J, Liang H. Natural killer T cell cytotoxic activity in Cervical cancer is facilitated by the LINC00240/microRNA-124-3p/STAT3/MICA axis. Cancer Lett. 2020;474:63–73. https://doi.org/10.1016/j.canlet.2019.12.038.

Article  CAS  PubMed  Google Scholar 

Ku GW, Kang Y, Yu SL, Park J, Park S, Jeong IB, et al. LncRNA LINC00240 suppresses invasion and migration in non-small cell Lung cancer by sponging miR-7-5p. BMC Cancer. 2021;21(1):44. https://doi.org/10.1186/s12885-020-07755-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, Zhang Z, Xia C. Long non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis. Bioengineered. 2021;12(2):9678–91. https://doi.org/10.1080/21655979.2021.1983276.

Article  CAS  PubMed  Google Scholar 

Chen X, Wu G, Qing J, Li C, Chen X, Shen J. LINC00240 knockdown inhibits nasopharyngeal carcinoma progress by targeting miR-26a-5p. J Clin Lab Anal. 2022;36(5):e24424. https://doi.org/10.1002/jcla.24424.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng S, Tang Q, Xie S, Wen S, Zhang H, Xie Z, et al. The role of noncoding RNA in Airway Allergic Diseases through Regulation of T Cell subsets. Mediators Inflamm. 2022;2022:6125698. https://doi.org/10.1155/2022/6125698.

Article  CAS  PubMed  Google Scholar 

Wu XH, Zhao SJ, Huang WQ, Huang LH, Luo XY, Long SL. Long non-coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA-135b-5p/GATA-3 axis in children with allergic rhinitis. Kaohsiung J Med Sci. 2022;38(10):971–80. https://doi.org/10.1002/kjm2.12587.

Article  CAS  PubMed  Google Scholar 

Yang C, Shangguan C, Cai C, Xu J, Qian X. LncRNA HCP5 participates in the Tregs functions in allergic rhinitis and drives Airway Mucosal Inflammatory response in the nasal epithelial cells. Inflammation. 2022;45(3):1281–97. https://doi.org/10.1007/s10753-022-01620-5.

Article  CAS  PubMed  Google Scholar 

Suojalehto H, Toskala E, Kilpelainen M, Majuri ML, Mitts C, Lindstrom I, et al. MicroRNA profiles in nasal mucosa of patients with allergic and nonallergic rhinitis and Asthma. Int Forum Allergy Rhinol. 2013;3(8):612–20. https://doi.org/10.1002/alr.21179.

Article  PubMed  Google Scholar 

Malmhall C, Alawieh S, Lu Y, Sjostrand M, Bossios A, Eldh M, et al. MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung. J Allergy Clin Immunol. 2014;133(5):1429–38. https://doi.org/10.1016/j.jaci.2013.11.008.

Article  CAS  PubMed  Google Scholar 

Zhu YQ, Liao B, Liu YH, Wang Z, Zhu XH, Chen XB, et al. MicroRNA-155 plays critical effects on Th2 factors expression and allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis. Eur Rev Med Pharmacol Sci. 2019;23(10):4097–109. https://doi.org/10.26355/eurrev_201905_17911.

Article  PubMed  Google Scholar 

Hammad NM, Nabil F, Elbehedy EM, Sedeek R, Gouda MI, Arafa MA, et al. Role of MicroRNA-155 as a potential biomarker for allergic Rhinitis in Children. Can Respir J. 2021;2021:5554461. https://doi.org/10.1155/2021/5554461.

Article  PubMed  PubMed Central  Google Scholar 

Zhu Y, Ye F, Fu Y, Zhu X, Wang Z, Wu S, et al. MicroRNA-155-5p regulates the Th1/Th2 cytokines expression and the apoptosis of group 2 innate lymphoid cells via targeting TP53INP1 in allergic rhinitis. Int Immunopharmacol. 2021;101(Pt B):108317. https://doi.org/10.1016/j.intimp.2021.108317.

Article  CAS  PubMed  Google Scholar 

Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol. 2010;11(6):527–34. https://doi.org/10.1038/ni.1867.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scadding GK, Kariyawasam HH, Scadding G, Mirakian R, Buckley RJ, Dixon T, et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (revised Edition 2017; First Edition 2007). Clin Exp Allergy. 2017;47(7):856–89. https://doi.org/10.1111/cea.12953.

Article  CAS  PubMed  Google Scholar 

Cordero P, Campion J, Milagro FI, Goyenechea E, Steemburgo T, Javierre BM, et al. Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet. J Physiol Biochem. 2011;67(3):463–70. https://doi.org/10.1007/s13105-011-0084-4.

Article  CAS  PubMed  Google Scholar 

Agache I, Akdis CA. Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic Diseases. J Clin Invest. 2019;129(4):1493–503. https://doi.org/10.1172/JCI124611.

Article  PubMed  PubMed Central  Google Scholar 

Eifan AO, Durham SR. Pathogenesis of rhinitis. Clin Exp Allergy. 2016;46(9):1139–51. https://doi.org/10.1111/cea.12780.

Article  CAS  PubMed  Google Scholar 

Georas SN, Guo J, De Fanis U, Casolaro V. T-helper cell type-2 regulation in allergic Disease. Eur Respir J. 2005;26(6):1119–37. https://doi.org/10.1183/09031936.05.00006005.

Article  CAS  PubMed  Google Scholar 

Hoppenot D, Malakauskas K, Lavinskiene S, Bajoriuniene I, Kalinauskaite V, Sakalauskas R. Peripheral blood Th9 cells and eosinophil apoptosis in Asthma patients. Med (Kaunas). 2015;51(1):10–7. https://doi.org/10.1016/j.medici.2015.01.001.

Article  Google Scholar 

Shin JH, Kim DH, Kim BY, Kim SW, Hwang SH, Lee J, et al. Anti-interleukin-9 antibody increases the Effect of Allergen-Specific Immunotherapy in Murine allergic rhinitis. Allergy Asthma Immunol Res. 2017;9(3):237–46.