BIENENSTOCK HPVKJ. Significance of Sensory Neuropeptides and the Immune Response. Psychoneuroimmunology. 2011.

Chen C-S, Barnoud C, Scheiermann C. Peripheral neurotransmitters in the immune system. Curr Opin Physiol. 2021;19:73–9.

Google Scholar 

Emson P. Peptides as neurotransmitter candidates in the mammalian CNS. Prog Neurobiol. 1979;13(1):61–116.

CAS  Google Scholar 

Wei P, Keller C, Li L. Neuropeptides in gut-brain axis and their influence on host immunity and stress. Comput Struct Biotechnol J. 2020;18:843–51.

PubMed  PubMed Central  CAS  Google Scholar 

Mashaghi A, Marmalidou A, Tehrani M, Grace PM, Pothoulakis C, Dana R. Neuropeptide substance P and the immune response. Cell Mol Life Sci. 2016;73(22):4249–64.

PubMed  PubMed Central  CAS  Google Scholar 

Pavlovic S, Liezmann C, Blois SM, Joachim R, Kruse J, Romani N, et al. Substance P is a key mediator of stress-induced protection from allergic sensitization via modified antigen presentation. J Immunol. 2011;186(2):848–55.

PubMed  CAS  Google Scholar 

Scholzen TE, Brzoska T, Kalden DH, O’Reilly F, Armstrong CA, Luger TA, et al. Effect of ultraviolet light on the release of neuropeptides and neuroendocrine hormones in the skin: mediators of photodermatitis and cutaneous inflammation. J Investig Dermatol Symp Proc. 1999;4(1):55–60.

Eschenfelder CC, Benrath J, Zimmermann M, Gillardon F. Involvement of substance P in ultraviolet irradiation-induced inflammation in rat skin. Eur J Neurosci. 1995;7(7):1520–6.

PubMed  CAS  Google Scholar 

Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA. Substance P activates Mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol. 2017;140(2):447–e533.

PubMed  PubMed Central  CAS  Google Scholar 

Borhegyi Z, Leranth C. Substance P innervation of the rat hippocampal formation. J Comp Neurol. 1997;384(1):41–58.

PubMed  CAS  Google Scholar 

Dasgupta A, Baby N, Krishna K, Hakim M, Wong YP, Behnisch T, et al. Substance P induces plasticity and synaptic tagging/capture in rat hippocampal area CA2. Proc Natl Acad Sci U S A. 2017;114(41):E8741–9.

PubMed  PubMed Central  CAS  Google Scholar 

Quartara L, Maggi CA. The Tachykinin NK1 receptor. Part II: distribution and pathophysiological roles. Neuropeptides. 1998;32(1):1–49.

PubMed  CAS  Google Scholar 

Maeno H, Kiyama H, Tohyama M. Distribution of the substance P receptor (NK-1 receptor) in the central nervous system. Brain Res Mol Brain Res. 1993;18(1–2):43–58.

PubMed  CAS  Google Scholar 

Lee YS, Silva AJ. The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci. 2009;10(2):126–40.

PubMed  PubMed Central  CAS  Google Scholar 

Yu Y, Zeng C, Shu S, Liu X, Li C. Similar effects of substance P on learning and memory function between hippocampus and striatal marginal division. Neural Regen Res. 2014;9(8):857–63.

PubMed  PubMed Central  CAS  Google Scholar 

Hasenöhrl RU, Huston JP, Schuurman T. Neuropeptide substance P improves water maze performance in aged rats. Psychopharmacology. 1990;101(1):23–6.

PubMed  Google Scholar 

Tomaz C, Nogueira PJ. Facilitation of memory by peripheral administration of substance P. Behav Brain Res. 1997;83(1–2):143–5.

PubMed  CAS  Google Scholar 

Slominski A, Wortsman J, Paus R, Elias PM, Tobin DJ, Feingold KR. Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech. 2008;5(2):137–44.

PubMed  PubMed Central  Google Scholar 

Parikh S, Parikh R, Michael K, Bikovski L, Barnabas G, Mardamshina M, et al. Food-seeking behavior is triggered by skin ultraviolet exposure in males. Nat Metabolism. 2022;4(7):883–900.

CAS  Google Scholar 

Han M, Ban J-J, Bae J-S, Shin C-Y, Lee DH, Chung JH. UV irradiation to mouse skin decreases hippocampal neurogenesis and synaptic protein expression via HPA axis activation. Sci Rep. 2017;7(1):15574.

PubMed  PubMed Central  Google Scholar 

Zhu H, Wang N, Yao L, Chen Q, Zhang R, Qian J, et al. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell. 2018;173(7):1716–e2717.

PubMed  CAS  Google Scholar 

Chen Y, Lyga J. Brain-skin connection: stress, inflammation and skin aging. Inflamm Allergy Drug Targets. 2014;13(3):177–90.

PubMed  PubMed Central  CAS  Google Scholar 

Muñoz M, Coveñas R. Involvement of substance P and the NK-1 receptor in human pathology. Amino Acids. 2014;46(7):1727–50.

PubMed  Google Scholar 

Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V. The Tachykinin peptide family. Pharmacol Rev. 2002;54(2):285–322.

PubMed  CAS  Google Scholar 

Chappa AK, Audus KL, Lunte SM. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006;23(6):1201–8.

PubMed  CAS  Google Scholar 

Tomoe S, Iwamoto I, Tomioka H, Yoshida S. Comparison of substance P-induced and compound 48/80-induced neutrophil infiltrations in mouse skin. Int Arch Allergy Immunol. 1992;97(3):237–42.

PubMed  CAS  Google Scholar 

Park G, Ryu C, Kim S, Jeong SJ, Koo JW, Lee YS, et al. Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice. Cell Rep. 2021;35(6):109104.

PubMed  CAS  Google Scholar 

Yoon KN, Kim Y, Cui Y, Ji J, Park G, Chung JH, et al. Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus. Mol Brain. 2022;15(1):102.

PubMed  PubMed Central  CAS  Google Scholar 

Yoon K-N, Kim SY, Ji J, Cui Y, Quan QL, Park G, et al. Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway. Exp Mol Med. 2024;56(6):1401–11.

PubMed  PubMed Central  CAS  Google Scholar 

Kang M, Choi J, Han J, Araki T, Kim SW, Ryu HH et al. Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models. J Clin Invest. 2025;135(8).

Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, et al. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol. 2020;38(3):276–8.

PubMed  CAS  Google Scholar 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29(1):15–21.

PubMed  CAS  Google Scholar 

Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C. Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods. 2017;14(4):417–9.

PubMed  PubMed Central  CAS  Google Scholar 

Love MI, Huber W, Anders S. Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.

PubMed  PubMed Central  Google Scholar 

Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7.

PubMed  PubMed Central  CAS  Google Scholar 

Gu X, Mao X, Lussier MP, Hutchison MA, Zhou L, Hamra FK, et al. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nat Commun. 2016;7(1):10873.

PubMed  PubMed Central  CAS  Google Scholar 

Seigneur E, Polepalli JS, Südhof TC. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Proceedings of the National Academy of Sciences. 2018;115(43):E10235-E44.

Xin M, Yue T, Ma Z, Wu FF, Gow A, Lu QR. Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. J Neurosci. 2005;25(6):1354–65.

PubMed  PubMed Central  CAS  Google Scholar 

Tosic M, Rakic S, Matthieu J, Zecevic N. Identification of Golli and Myelin basic proteins in human brain during early development. Glia. 2002;37(3):219–28.

PubMed  CAS  Google Scholar 

Micheli L, Caruso M, D’Andrea G, Volpe D, Ceccarelli M, Tirone F. Survey of transcriptome analyses of hippocampal neurogenesis with focus on adult dentate gyrus stem cells. Front Cell Dev Biol. 2025;13:1605116.

PubMed  PubMed Central