Chao CT, Lin SH. Uremic toxins and frailty in patients with chronic kidney disease: a molecular insight. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22126270.

Article  Google Scholar 

Lim YJ, Sidor NA, Tonial NC, Che A, Urquhart BL. Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets. Toxins (Basel). 2021. https://doi.org/10.3390/toxins13020142.

Article  Google Scholar 

Chen JH, Chao CT, Huang JW, Hung KY, Liu SH, Tarng DC, Chiang CK. Early elimination of uremic toxin ameliorates AKI-to-CKD transition. Clin Sci (Lond). 2021;135:2643–58.

Google Scholar 

Campillo S, Bohorquez L, Gutiérrez-Calabrés E, García-Ayuso D, Miguel V, Griera M, Calle Y, de Frutos S, Rodríguez-Puyol M, Rodríguez-Puyol D, Calleros L. Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation. Exp Mol Med. 2022;54:226–38.

Google Scholar 

Opdebeeck B, D’Haese PC, Verhulst A. Molecular and cellular mechanisms that induce arterial calcification by indoxyl sulfate and P-cresyl sulfate. Toxins (Basel). 2020;12:58.

Google Scholar 

Lin YT, Wu PH, Tsai YC, Hsu YL, Wang HY, Kuo MC, Kuo PL, Hwang SJ. Indoxyl sulfate induces apoptosis through oxidative stress and mitogen-activated protein kinase signaling pathway inhibition in human astrocytes. J Clin Med. 2019;8:191.

Google Scholar 

Tanaka H, Iwasaki Y, Yamato H, Mori Y, Komaba H, Watanabe H, Maruyama T, Fukagawa M. P-cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013;56:347–54.

Google Scholar 

Deng M, Li X, Li W, Gong J, Zhang X, Ge S, Zhao L. Short-chain fatty acids alleviate hepatocyte apoptosis induced by gut-derived protein-bound uremic toxins. Front Nutr. 2021;8: 756730.

Google Scholar 

Gouroju S, Rao P, Bitla AR, Vinapamula KS, Manohar SM, Vishnubhotla S. Role of gut-derived uremic toxins on oxidative stress and inflammation in patients with chronic kidney disease. Indian J Nephrol. 2017;27:359–64.

Google Scholar 

Harlacher E, Wollenhaupt J, Baaten C, Noels H. Impact of uremic toxins on endothelial dysfunction in chronic kidney disease: a systematic review. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23010531.

Article  Google Scholar 

Huang SY, Chen YA, Chen SA, Chen YJ, Lin YK. Uremic toxins - novel arrhythmogenic factor in chronic kidney disease - related atrial fibrillation. Acta Cardiol Sin. 2016;32:259–64.

Google Scholar 

Niwa T. Targeting protein-bound uremic toxins in chronic kidney disease. Expert Opin Ther Targets. 2013;17:1287–301.

Google Scholar 

Leong SC, Sirich TL. Indoxyl sulfate-review of toxicity and therapeutic strategies. Toxins (Basel). 2016. https://doi.org/10.3390/toxins8120358.

Article  Google Scholar 

Ryu JH, Yu M, Lee S, Ryu DR, Kim SJ, Kang DH, Choi KB. AST-120 improves microvascular endothelial dysfunction in end-stage renal disease patients receiving hemodialysis. Yonsei Med J. 2016;57:942–9.

Google Scholar 

Su PY, Lee YH, Kuo LN, Chen YC, Chen C, Kang YN, Chang EH. Efficacy of AST-120 for patients with chronic kidney disease: a network meta-analysis of randomized controlled trials. Front Pharmacol. 2021;12: 676345.

Google Scholar 

Reiter E, Jiang Q, Christen S. Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol Aspects Med. 2007;28:668–91.

Google Scholar 

Warner K, Gehring MM. High-temperature natural antioxidant improves soy oil for frying. J Food Sci. 2009;74:C500-505.

Google Scholar 

Murkovic M, Hillebrand A, Winkler J, Pfannhauser W. Variability of vitamin E content in pumpkin seeds (Cucurbita pepo L.). Z Lebensm Unters Forsch. 1996;202:275–8.

Google Scholar 

Elmadfa I, Park E. Impact of diets with corn oil or olive/sunflower oils on DNA damage in healthy young men. Eur J Nutr. 1999;38:286–92.

Google Scholar 

Jiang Q, Im S, Wagner JG, Hernandez ML, Peden DB. Gamma-tocopherol, a major form of vitamin E in diets: insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management. Free Radic Biol Med. 2022;178:347–59.

Google Scholar 

Jiang Q, Christen S, Shigenaga MK, Ames BN. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001;74:714–22.

Google Scholar 

Abdulla KA, Um CY, Gross MD, Bostick RM. Circulating γ-tocopherol concentrations are inversely associated with antioxidant exposures and directly associated with systemic oxidative stress and inflammation in adults. J Nutr. 2018;148:1453–61.

Google Scholar 

Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol–an underestimated vitamin? Ann Nutr Metab. 2004;48:169–88.

Google Scholar 

Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15:505–22.

Google Scholar 

Himmelfarb J, Phinney S, Ikizler TA, Kane J, McMonagle E, Miller G. Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. J Ren Nutr. 2007;17:296–304.

Google Scholar 

Zhang Y, Yang S, Liu M, Wu Q, Ye Z, Zhou C, He P, Zhang Y, Gan X, Qin X. Dietary vitamin E and tocopherol isoforms and incident chronic kidney disease: a 30-y follow-up study from young adulthood to midlife. Free Radic Biol Med. 2022;190:284–91.

Google Scholar 

McCormick CC, Parker RS. The cytotoxicity of vitamin E is both vitamer- and cell-specific and involves a selectable trait. J Nutr. 2004;134:3335–42.

Google Scholar 

Sachdeva R, Thomas B, Wang X, Ma J, Jones KH, Hatcher PG, Cornwell DG. Tocopherol metabolism using thermochemolysis: chemical and biological properties of gamma-tocopherol, gamma-carboxyethyl-hydroxychroman, and their quinones. Chem Res Toxicol. 2005;18:1018–25.

Google Scholar 

Abraham A, Kattoor AJ, Saldeen T, Mehta JL. Vitamin E and its anticancer effects. Crit Rev Food Sci Nutr. 2019;59:2831–8.

Google Scholar 

Campbell SE, Stone WL, Lee S, Whaley S, Yang H, Qui M, Goforth P, Sherman D, McHaffie D, Krishnan K. Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer. 2006;6:13.

Google Scholar 

Torricelli P, Caraglia M, Abbruzzese A, Beninati S. γ-Tocopherol inhibits human prostate cancer cell proliferation by up-regulation of transglutaminase 2 and down-regulation of cyclins. Amino Acids. 2013;44:45–51.

Google Scholar 

Mathur P, Ding Z, Saldeen T, Mehta JL. Tocopherols in the prevention and treatment of atherosclerosis and related cardiovascular disease. Clin Cardiol. 2015;38:570–6.

Google Scholar 

Thompson MD, Cooney RV. The potential physiological role of γ-tocopherol in human health: a qualitative review. Nutr Cancer. 2020;72:808–25.

Google Scholar 

Abdulla KA, Um CY, Gross MD, Bostick RM. Circulating gamma-tocopherol concentrations are inversely associated with antioxidant exposures and directly associated with systemic oxidative stress and inflammation in adults. J Nutr. 2018;148:1453–61.

Google Scholar 

de Almada-Vilhena AO, Dos Santos OVM, Machado MA, Nagamachi CY, Pieczarka JC. Prospecting pharmacologically active biocompounds from the amazon rainforest: in vitro approaches, mechanisms of action based on chemical structure, and perspectives on human therapeutic use. Pharmaceuticals Basel. 2024;17:1449.

Google Scholar 

Vaou N, Stavropoulou E, Voidarou CC, Tsakris Z, Rozos G, Tsigalou C, Bezirtzoglou E. Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects. Antibiotics (Basel). 2022. https://doi.org/10.3390/antibiotics11081014.

Article  Google Scholar 

Jung WK, Park SB, Yu HY, Kim YH, Kim J. Effect of esculetin on tert-butyl hydroperoxide-induced oxidative injury in retinal pigment epithelial cells in vitro. Molecules. 2022. https://doi.org/10.3390/molecules27248970.

Article  Google Scholar 

Martínez MA, Ares I, Martínez M, Lopez-Torres B, Maximiliano JE, Rodríguez JL, Martínez-Larrañaga MR, Anadón A, Peteiro C, Rubiño S, Hortos M. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide. Food Chem Toxicol. 2021;156: 112460.

Google Scholar 

Shvedova AA, Tyurina YY, Gorbunov NV, Tyurin VA, Castranova V, Kommineni C, Ojimba J, Gandley R, McLaughlin MK, Kagan VE. tert-butyl hydroperoxide/hemoglobin-induced oxidative stress and damage to vascular smooth muscle cells: different effects of nitric oxide and nitrosothiols. Biochem Pharmacol. 1999;57:989–1001.

Google Scholar 

Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM. γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death. J Pharmacol Exp Ther. 2012;340:330–8.

Google Scholar 

Tesoriere L, Attanzio A, Allegra M, Cilla A, Gentile C, Livrea MA. Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptosis. Cell Physiol Biochem. 2014;34:1075–89.

Google Scholar 

You JS, Lim H, Seo JY, Kang KR, Kim DK, Oh JS, Seo YS, Lee GJ, Kim JS, Kim HJ, Yu SK, Kim JS. 25-hydroxycholesterol-induced oxiaapoptophagy in L929 mouse fibroblast cell line. Molecules. 2021. https://doi.org/10.3390/molecules27010199.

Article  Google Scholar 

Yuan XM, Sultana N, Siraj N, Ward LJ, Ghafouri B, Li W. Autophagy induction protects against 7-oxysterol-induced cell death via lysosomal pathway and oxidative stress. J Cell Death. 2016;9:1–7.

Google Scholar