A septo–entorhinal GABAergic pathway that enables switching between episodic memories

Tse, D. et al. Schemas and memory consolidation. Science 316, 76–82 (2007).

Article  CAS  PubMed  Google Scholar 

Dudai, Y. The restless engram: consolidations never end. Annu. Rev. Neurosci. 35, 227–247 (2012).

Article  CAS  PubMed  Google Scholar 

Richards, B. A. et al. Patterns across multiple memories are identified over time. Nat. Neurosci. 17, 981–986 (2014).

Article  CAS  PubMed  Google Scholar 

Uddin, L. Q. Cognitive and behavioural flexibility: neural mechanisms and clinical considerations. Nat. Rev. Neurosci. 22, 167–179 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis, R. L. & Zhong, Y. The biology of forgetting—a perspective. Neuron 95, 490–503 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trouche, S., Sasaki, J. M., Tu, T. & Reijmers, L. G. Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses. Neuron 80, 1054–1065 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grewe, B. F. et al. Neural ensemble dynamics underlying a long-term associative memory. Nature 543, 670–675 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alonso, A., van der Meij, J., Tse, D. & Genzel, L. Naive to expert: considering the role of previous knowledge in memory. Brain Neurosci. Adv. 4, 2398212820948686 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Josselyn, S. A. & Tonegawa, S. Memory engrams: recalling the past and imagining the future. Science 367, eaaw4325 (2020).

Cho, H. Y. et al. Turnover of fear engram cells by repeated experience. Curr. Biol. 31, 5450–5461 (2021).

Article  CAS  PubMed  Google Scholar 

Lei, B. et al. Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating. Neuron 113, 471–485 (2025).

Article  CAS  PubMed  Google Scholar 

Lee, J. L. Memory reconsolidation mediates the strengthening of memories by additional learning. Nat. Neurosci. 11, 1264–1266 (2008).

Article  CAS  PubMed  Google Scholar 

Winson, J. Loss of hippocampal theta rhythm results in spatial memory deficit in the rat. Science 201, 160–163 (1978).

Article  CAS  PubMed  Google Scholar 

Morris, R. G., Garrud, P., Rawlins, J. N. & O’Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681–683 (1982).

Article  CAS  PubMed  Google Scholar 

Mizumori, S. J., Perez, G. M., Alvarado, M. C., Barnes, C. A. & McNaughton, B. L. Reversible inactivation of the medial septum differentially affects two forms of learning in rats. Brain Res. 528, 12–20 (1990).

Article  CAS  PubMed  Google Scholar 

Sans-Dublanc, A. et al. Septal GABAergic inputs to CA1 govern contextual memory retrieval. Sci. Adv. 6, eaba5003 (2020).

Schlesiger, M. I. et al. Two septal-entorhinal GABAergic projections differentially control coding properties of spatially tuned neurons in the medial entorhinal cortex. Cell Rep. 34, 108801 (2021).

Article  CAS  PubMed  Google Scholar 

Freund, T. F. & Antal, M. GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus. Nature 336, 170–173 (1988).

Article  CAS  PubMed  Google Scholar 

Gonzalez-Sulser, A. et al. GABAergic projections from the medial septum selectively inhibit interneurons in the medial entorhinal cortex. J. Neurosci. 34, 16739–16743 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Fuchs, E. C. et al. Local and distant input controlling excitation in layer II of the medial entorhinal cortex. Neuron 89, 194–208 (2016).

Article  CAS  PubMed  Google Scholar 

Unal, G., Joshi, A., Viney, T. J., Kis, V. & Somogyi, P. Synaptic targets of medial septal projections in the hippocampus and extrahippocampal cortices of the mouse. J. Neurosci. 35, 15812–15826 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viney, T. J. et al. Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum. eLife 7, e34395 (2018).

Fenno, L. E. et al. Targeting cells with single vectors using multiple-feature Boolean logic. Nat. Methods 11, 763–772 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fenno, L. E. et al. Comprehensive dual- and triple-feature intersectional single-vector delivery of diverse functional payloads to cells of behaving mammals. Neuron 107, 836–853 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broussard, G. J. et al. In vivo measurement of afferent activity with axon-specific calcium imaging. Nat. Neurosci. 21, 1272–1280 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guzowski, J. F., McNaughton, B. L., Barnes, C. A. & Worley, P. F. Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat. Neurosci. 2, 1120–1124 (1999).

Article  CAS  PubMed  Google Scholar 

Liu, X. et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484, 381–385 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garner, A. R. et al. Generation of a synthetic memory trace. Science 335, 1513–1516 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenzie, S. et al. Hippocampal representation of related and opposing memories develop within distinct, hierarchically organized neural schemas. Neuron 83, 202–215 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanaka, K. Z. et al. Cortical representations are reinstated by the hippocampus during memory retrieval. Neuron 84, 347–354 (2014).

Article  CAS  PubMed  Google Scholar 

Leao, R. N., Targino, Z. H., Colom, L. V. & Fisahn, A. Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca. J. Neurophysiol. 113, 971–980 (2015).

Article  CAS  PubMed  Google Scholar 

Borhegyi, Z., Varga, V., Szilagyi, N., Fabo, D. & Freund, T. F. Phase segregation of medial septal GABAergic neurons during hippocampal theta activity. J. Neurosci. 24, 8470–8479 (2004).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rueckemann, J. W. et al. Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons. Hippocampus 26, 246–260 (2016).

Article  PubMed 

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