Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges

Ngugi, A. K., Bottomley, C., Kleinschmidt, I., Sander, J. W. & Newton, C. R. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia 51, 883–890 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Smith, E. H. et al. Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges. eLife 11, e73541 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baumgartner, C. et al. Propagation of interictal epileptic activity in temporal lobe epilepsy. Neurology 45, 118–122 (1995).

Article  CAS  PubMed  Google Scholar 

Kleen, J. K. & Kirsch, H. E. The nociferous influence of interictal discharges on memory. Brain J. Neurol. 140, 2072–2074 (2017).

Article  Google Scholar 

Kleen, J. K., Scott, R. C., Lenck-Santini, P.-P. & Holmes, G. L. in Jasper’s Basic Mechanisms of the Epilepsies (eds Noebels, J. L. et al.) (NCBI, 2012).

Baud, M. O. et al. Multi-day rhythms modulate seizure risk in epilepsy. Nat. Commun. 9, 88 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Karoly, P. J. et al. Cycles in epilepsy. Nat. Rev. Neurol. 17, 267–284 (2021).

Article  PubMed  Google Scholar 

Jarosiewicz, B. & Morrell, M. The RNS system: brain-responsive neurostimulation for the treatment of epilepsy. Expert Rev. Med. Devices 18, 129–138 (2021).

Article  CAS  PubMed  Google Scholar 

Nair, D. R. et al. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology 95, e1244–e1256 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Rao, V. R. & Rolston, J. D. Unearthing the mechanisms of responsive neurostimulation for epilepsy. Commun. Med. 3, 166 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Razavi, B. et al. Real-world experience with direct brain-responsive neurostimulation for focal onset seizures. Epilepsia 61, 1749–1757 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Dutta, S., Ackermann, E. & Kemere, C. Analysis of an open source, closed-loop, realtime system for hippocampal sharp-wave ripple disruption. J. Neural Eng. 16, 016009 (2018).

Article  PubMed  Google Scholar 

Jadhav, S. P., Kemere, C., German, P. W. & Frank, L. M. Awake hippocampal sharp-wave ripples support spatial memory. Science 336, 1454–1458 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Curtis, M. & Avanzini, G. Interictal spikes in focal epileptogenesis. Prog. Neurobiol. 63, 541–567 (2001).

Article  PubMed  Google Scholar 

Castro-Alamancos, M. A. Origin of synchronized oscillations induced by neocortical disinhibition in vivo. J. Neurosci. 20, 9195–9206 (2000).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prince, D. A. & Avoli, M. in Jasper’s Basic Mechanisms of the Epilepsies (eds Noebels, J. L. et al.) (Oxford Univ. Press, 2024).

Keller, C. J. et al. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain J. Neurol. 133, 1668–1681 (2010).

Article  Google Scholar 

Tatti, R., Haley, M. S., Swanson, O., Tselha, T. & Maffei, A. Neurophysiology and regulation of the balance between excitation and inhibition in neocortical circuits. Biol. Psychiatry 81, 821–831 (2017).

Article  PubMed  Google Scholar 

Liou, J. et al. Role of inhibitory control in modulating focal seizure spread. Brain 141, 2083–2097 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Ziburkus, J., Cressman, J. R., Barreto, E. & Schiff, S. J. Interneuron and pyramidal cell interplay during in vitro seizure-like events. J. Neurophysiol. 95, 3948–3954 (2006).

Article  PubMed  PubMed Central  Google Scholar 

Kienitz, R. et al. Temporal lobe epilepsy is dominated by region specific interictal cortical inhibition. Preprint at bioRxiv https://doi.org/10.1101/2024.11.30.626179 (2024).

Fabo, D. et al. The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex. Sci. Rep. 13, 9620 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ulbert, I., Heit, G., Madsen, J., Karmos, G. & Halgren, E. Laminar analysis of human neocortical interictal spike generation and propagation: current source density and multiunit analysis in vivo. Epilepsia 45, 48–56 (2004).

Article  PubMed  Google Scholar 

Csercsa, R. et al. Laminar analysis of slow wave activity in humans. Brain J. Neurol. 133, 2814–2829 (2010).

Article  Google Scholar 

Ung, H. et al. Interictal epileptiform activity outside the seizure onset zone impacts cognition. Brain J. Neurol. 140, 2157–2168 (2017).

Article  Google Scholar 

Silva, A. B. et al. Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms. Epilepsia 64, 3266–3278 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Kleen, J. K. et al. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology 81, 18–24 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henin, S. et al. Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing. Brain J. Neurol. 144, 1590–1602 (2021).

Article  Google Scholar 

Reed, C. M. et al. Extent of single-neuron activity modulation by hippocampal interictal discharges predicts declarative memory disruption in humans. J. Neurosci. 40, 682–693 (2020).

Article  CAS  PubMed  Google Scholar 

Jun, J. J. et al. Fully integrated silicon probes for high-density recording of neural activity. Nature 551, 232–236 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu, S. et al. Real-time readout of large-scale unsorted neural ensemble place codes. Cell Rep. 25, 2635–2642.e5 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciliberti, D., Michon, F. & Kloosterman, F. Real-time classification of experience-related ensemble spiking patterns for closed-loop applications. eLife 7, e36275 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Topalovic, U. et al. A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans. Nat. Neurosci. 26, 517–527 (2023).

CAS  PubMed  PubMed Central  Google Scholar 

Flesher, S. N. et al. A brain–computer interface that evokes tactile sensations improves robotic arm control. Science 372, 831–836 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paulk, A. C. et al. Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex. Nat. Neurosci. 25, 252–263 (2022).

Article  CAS  PubMed  Google Scholar 

Chung, J. E. et al. High-density single-unit human cortical recordings using the Neuropixels probe. Neuron 110, 2409–2421.e3 (2022).

Article  C

Comments (0)

No login
gif