Saab, A. S., Tzvetanova, I. D. & Nave, K. A. The role of myelin and oligodendrocytes in axonal energy metabolism. Curr. Opin. Neurobiol. 23, 1065–1072 (2013).
Article CAS PubMed Google Scholar
Wentling, M. et al. A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis. Brain 142, 2756–2774 (2019).
Funfschilling, U. et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 485, 517–521 (2012).
Article PubMed PubMed Central Google Scholar
Lee, Y. et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 487, 443–448 (2012).
Article CAS PubMed PubMed Central Google Scholar
Edmond, J., Auestad, N., Robbins, R. A. & Bergstrom, J. D. Ketone body metabolism in the neonate: development and the effect of diet. Fed. Proc. 44, 2359–2364 (1985).
Lanoue, L., Liu, X. J. & Koski, K. G. Postnatal profiles of glycogenolysis and gluconeogenesis are modified in rat pups by maternal dietary glucose restriction. J. Nutr. 129, 820–827 (1999).
Article CAS PubMed Google Scholar
Barres, B. A. et al. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70, 31–46 (1992).
Article CAS PubMed Google Scholar
Trapp, B. D., Nishiyama, A., Cheng, D. & Macklin, W. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J. Cell Biol. 137, 459–468 (1997).
Article CAS PubMed PubMed Central Google Scholar
Calver, A. R. et al. Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron 20, 869–882 (1998).
Article CAS PubMed Google Scholar
Casaccia-Bonnefil, P. Cell death in the oligodendrocyte lineage: a molecular perspective of life/death decisions in development and disease. Glia 29, 124–135 (2000).
Article CAS PubMed Google Scholar
Weng, Q. et al. Single-cell transcriptomics uncovers glial progenitor diversity and cell fate determinants during development and gliomagenesis. Cell Stem Cell 24, 707–723 (2019).
Article CAS PubMed PubMed Central Google Scholar
Spitzer, S. O. et al. Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age. Neuron 101, 459–471.e5 (2019).
Article CAS PubMed PubMed Central Google Scholar
Marques, S., van Bruggen, D. & Castelo-Branco, G. Single-cell RNA sequencing of oligodendrocyte lineage cells from the mouse central nervous system. Methods Mol. Biol. 1936, 1–21 (2019).
Article CAS PubMed Google Scholar
Viganò, F., Möbius, W., Götz, M. & Dimou, L. Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat. Neurosci. 16, 1370–1372 (2013).
Thornton, M. A. et al. Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis. Nat. Neurosci. 27, 846–861 (2024).
Article CAS PubMed PubMed Central Google Scholar
Marin-Husstege, M., Muggironi, M., Liu, A. & Casaccia-Bonnefil, P. Histone deacetylase activity is necessary for oligodendrocyte lineage progression. J. Neurosci. 22, 10333–10345 (2002).
Article CAS PubMed PubMed Central Google Scholar
Shen, S., Li, J. & Casaccia-Bonnefil, P. Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J. Cell Biol. 169, 577–589 (2005).
Article CAS PubMed PubMed Central Google Scholar
Shen, S. et al. Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat. Neurosci. 11, 1024–1034 (2008).
Article CAS PubMed PubMed Central Google Scholar
Wellen, K. E. et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076–1080 (2009).
Article CAS PubMed PubMed Central Google Scholar
Coelho-Santos, V. & Shih, A. Y. Postnatal development of cerebrovascular structure and the neurogliovascular unit. Wiley Interdiscip. Rev. Dev. Biol. 9, e363 (2020).
Hahn, A. et al. Large-scale characterization of the microvascular geometry in development and disease by tissue clearing and quantitative ultramicroscopy. J. Cereb. Blood Flow Metab. 41, 1536–1546 (2021).
Article CAS PubMed Google Scholar
Schaeffer, S. & Iadecola, C. Revisiting the neurovascular unit. Nat. Neurosci. 24, 1198–1209 (2021).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Y. et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34, 11929–11947 (2014).
Article CAS PubMed PubMed Central Google Scholar
Hasel, P. et al. Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates. Cell Rep. 44, 115344 (2025).
Article CAS PubMed PubMed Central Google Scholar
Zhu, J. & Thompson, C. B. Metabolic regulation of cell growth and proliferation. Nat. Rev. Mol. Cell Biol. 20, 436–450 (2019).
Article CAS PubMed PubMed Central Google Scholar
Magri, L. et al. E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation. J. Neurosci. 34, 1481–1493 (2014).
Article CAS PubMed PubMed Central Google Scholar
Liu, J. et al. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. J. Neurosci. 35, 352–365 (2015).
Article PubMed PubMed Central Google Scholar
Richon, V. M. et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc. Natl Acad. Sci. USA 95, 3003–3007 (1998).
Article CAS PubMed PubMed Central Google Scholar
Sivanand, S., Viney, I. & Wellen, K. E. Spatiotemporal control of acetyl-CoA metabolism in chromatin regulation. Trends Biochem. Sci. 43, 61–74 (2018).
Article CAS PubMed Google Scholar
Palmieri, F. The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol. Asp. Med. 34, 465–484 (2013).
Marques, S. et al. Transcriptional convergence of
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