Early postoperative LDDST enhances remission prediction beyond morning cortisol in cushing’s disease

Fleseriu M, Auchus R, Bancos I et al (2021) Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes Endocrinol 9(12):847–75. https://doi.org/10.1016/S2213-8587(21)00235-7

Article  PubMed  PubMed Central  Google Scholar 

Honegger J, Nasi-Kordhishti I (2022) Surgery and perioperative management of patients with Cushing’s disease. J Neuroendocrinol 34(8):e13177. https://doi.org/10.1111/jne.13177

Article  CAS  PubMed  Google Scholar 

Petersenn S, Beckers A, Ferone D et al (2015) Therapy of endocrine disease: outcomes in patients with cushing’s disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recurrence. Eur J Endocrinol 172(6):R227–R239. https://doi.org/10.1530/EJE-14-0883[published Online First: 20150119]

Article  CAS  PubMed  Google Scholar 

Nieman LK, Biller BM, Findling JW et al (2015) Treatment of Cushing’s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 100(8):2807–31. https://doi.org/10.1210/jc.2015-1818

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honegger J, Grimm F (2018) The experience with transsphenoidal surgery and its importance to outcomes. Pituitary 21(5):545–55. https://doi.org/10.1007/s11102-018-0904-4

Article  PubMed  Google Scholar 

Avgerinos PC, Chrousos GP, Nieman LK, Oldfield EH, Loriaux DL, Cutler GB Jr. (1987) The corticotropin-releasing hormone test in the postoperative evaluation of patients with cushing’s syndrome. J Clin Endocrinol Metab 65(5):906–13. https://doi.org/10.1210/jcem-65-5-906

Article  CAS  PubMed  Google Scholar 

Lindsay JR, Oldfield EH, Stratakis CA, Nieman LK (2011) The postoperative basal cortisol and CRH tests for prediction of long-term remission from Cushing’s disease after transsphenoidal surgery. J Clin Endocrinol Metab 96(7):2057–64. https://doi.org/10.1210/jc.2011-0456

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liddle GW (1960) Tests of pituitary-adrenal suppressibility in the diagnosis of cushing’s syndrome. J Clin Endocrinol Metab 20:1539–1560. https://doi.org/10.1210/jcem-20-12-1539

Article  CAS  PubMed  Google Scholar 

Sahin M, Kebapcilar L, Taslipinar A et al (2009) Comparison of 1 mg and 2 mg overnight dexamethasone suppression tests for the screening of Cushing’s syndrome in obese patients. Intern Med 48(1):33–9. https://doi.org/10.2169/internalmedicine.48.1234

Article  PubMed  Google Scholar 

Urwyler SA, Cupa N, Christ-Crain M (2017) Comparison of 1 mg versus 2 mg dexamethasone suppression test in patients with obesity. Horm Metab Res 49(11):854–59. https://doi.org/10.1055/s-0043-119128

Article  CAS  PubMed  Google Scholar 

Hofmann BM, Hlavac M, Martinez R, Buchfelder M, Muller OA, Fahlbusch R (2008) Long-term results after microsurgery for Cushing disease: experience with 426 primary operations over 35 years. J Neurosurg 108(1):9–18. https://doi.org/10.3171/JNS/2008/108/01/0009

Article  PubMed  Google Scholar 

Stroud A, Dhaliwal P, Harvey RJ et al (2022) Low but not undetectable early postoperative nadir serum cortisol predicts sustained remission in Cushing’s disease. Endocr Oncol 2(1):19–31. https://doi.org/10.1530/EO-21-0026

Article  PubMed  PubMed Central  Google Scholar 

Wang F, Catalino MP, Bi WL et al (2021) Postoperative day 1 morning cortisol value as a biomarker to predict long-term remission of Cushing disease. J Clin Endocrinol Metab 106(1):e94–e102. https://doi.org/10.1210/clinem/dgaa773

Article  PubMed  Google Scholar 

Rees DA, Hanna FW, Davies JS, Mills RG, Vafidis J, Scanlon MF (2002) Long-term follow-up results of transsphenoidal surgery for cushing’s disease in a single centre using strict criteria for remission. Clin Endocrinol (Oxf) 56(4):541–551. https://doi.org/10.1046/j.1365-2265.2002.01511.x

Article  CAS  PubMed  Google Scholar 

Barbot M, Albiger N, Koutroumpi S et al (2013) Predicting late recurrence in surgically treated patients with Cushing’s disease. Clin Endocrinol (Oxf) 79(3):394–401. https://doi.org/10.1111/cen.12133

Article  CAS  PubMed  Google Scholar 

Costenaro F, Rodrigues TC, Rollin GA, Ferreira NP, Czepielewski MA (2014) Evaluation of Cushing’s disease remission after transsphenoidal surgery based on early serum cortisol dynamics. Clin Endocrinol (Oxf) 80(3):411–8. https://doi.org/10.1111/cen.12300

Article  CAS  PubMed  Google Scholar 

Valassi E, Biller BM, Swearingen B et al (2010) Delayed remission after transsphenoidal surgery in patients with Cushing’s disease. J Clin Endocrinol Metab 95(2):601–10. https://doi.org/10.1210/jc.2009-1672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hameed N, Yedinak CG, Brzana J et al (2013) Remission rate after transsphenoidal surgery in patients with pathologically confirmed Cushing’s disease, the role of cortisol, ACTH assessment and immediate reoperation: a large single center experience. Pituitary 16(4):452–8. https://doi.org/10.1007/s11102-012-0455-z

Article  CAS  PubMed  Google Scholar 

Aranda G, Ensenat J, Mora M et al (2015) Long-term remission and recurrence rate in a cohort of Cushing’s disease: the need for long-term follow-up. Pituitary 18(1):142–9. https://doi.org/10.1007/s11102-014-0567-8

Article  CAS  PubMed  Google Scholar 

Uvelius E, Hoglund P, Valdemarsson S, Siesjo P (2018) An early post-operative ACTH suppression test can safely predict short- and long-term remission after surgery of Cushing’s disease. Pituitary 21(5):490–98. https://doi.org/10.1007/s11102-018-0902-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Catalino MP, Gelinne A, Ironside N et al (2022) Characterization of a paradoxical post-operative increase in serum cortisol in Cushing disease. Pituitary 25(2):340–47. https://doi.org/10.1007/s11102-021-01203-x

Article  CAS  PubMed  Google Scholar 

Asuzu D, Chatain GP, Hayes C et al (2017) Normalized early postoperative cortisol and ACTH values predict nonremission after surgery for Cushing disease. J Clin Endocrinol Metab 102(7):2179–87. https://doi.org/10.1210/jc.2016-3908

Article  PubMed  PubMed Central  Google Scholar 

Gupta N, Dutta A, Baruah MM et al (2023) An integrated clinical score to predict remission in Cushing’s disease. Indian J Endocrinol Metab 27(6):501–05. https://doi.org/10.4103/ijem.ijem_314_23

Article  CAS  PubMed  Google Scholar 

Bansal P, Lila A, Goroshi M et al (2017) Duration of post-operative hypocortisolism predicts sustained remission after pituitary surgery for Cushing’s disease. Endocr Connect 6(8):625–36. https://doi.org/10.1530/EC-17-0175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Varlamov EV, Vila G, Fleseriu M (2022) Perioperative management of a patient with Cushing disease. J Endocr Soc 6(3):bvac010. https://doi.org/10.1210/jendso/bvac010

Article  PubMed  PubMed Central  Google Scholar 

Ironside N, Chatain G, Asuzu D et al (2018) Earlier post-operative hypocortisolemia may predict durable remission from Cushing’s disease. Eur J Endocrinol 178(3):255–63. https://doi.org/10.1530/EJE-17-0873

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandraki KI, Kaltsas GA, Isidori AM et al (2013) Long-term remission and recurrence rates in Cushing’s disease: predictive factors in a single-centre study. Eur J Endocrinol 168(4):639–48. https://doi.org/10.1530/EJE-12-0921

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif