Gender differences in surgical outcomes and predictors of long term endocrine and metabolic morbidity in adults with craniopharyngioma

Muller HL (2020) The diagnosis and treatment of craniopharyngioma. Neuroendocrinology 110:753–766. https://doi.org/10.1159/000504512

Article  CAS  PubMed  Google Scholar 

Otte A, Muller HL (2021) Childhood-onset craniopharyngioma. J Clin Endocrinol Metab 106:E3820–E3836. https://doi.org/10.1210/CLINEM/DGAB397

Article  PubMed  Google Scholar 

Müller HL, Gebhardt U, Teske C, Faldum A, Zwiener I, Warmuth-Metz M et al (2011) Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol 165:17–24. https://doi.org/10.1530/EJE-11-0158

Article  CAS  PubMed  Google Scholar 

Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551. https://doi.org/10.3171/JNS.1998.89.4.0547

Article  CAS  PubMed  Google Scholar 

Nielsen EH, Feldt-Rasmussen U, Poulsgaard L, Kristensen L, Astrup J, Jørgensen JO et al (2011) Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults. J Neurooncol 104:755–763. https://doi.org/10.1007/S11060-011-0540-6

Article  CAS  PubMed  Google Scholar 

Apps JR, Muller HL, Hankinson TC, Yock TI, Martinez-Barbera JP (2023) Contemporary biological insights and clinical management of craniopharyngioma. Endocr Rev 44:518–538. https://doi.org/10.1210/ENDREV/BNAC035

Article  PubMed  Google Scholar 

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al (2021) The 2021 WHO classification of tumors of the central nervous system: A summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/NEUONC/NOAB106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hölsken A, Sill M, Merkle J, Schweizer L, Buchfelder M, Flitsch J et al (2016) Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles. Acta Neuropathol Commun 4:20. https://doi.org/10.1186/S40478-016-0287-6

Article  PubMed  PubMed Central  Google Scholar 

Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R et al (2011) Increased wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A 108:11482–11487. https://doi.org/10.1073/PNAS.1101553108/-/DCSUPPLEMENTAL/PNAS.201101553SI.PDF

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Alcubierre D, Feola T, Puliani G, Ferrigno R, Amodeo ME, d’Aniello F et al (2025) Endocrine and metabolic consequences of childhood-onset craniopharyngioma during the transition age: A literature review by the TALENT study group. Rev Endocr Metab Disord. https://doi.org/10.1007/S11154-025-09972-7

Article  PubMed  PubMed Central  Google Scholar 

Venegas E, Concepcion B, Martin T, Soto A (2015) Guía práctica Del Manejo y Tratamiento de Los Craneofaringiomas y Otras lesiones Paraselares. Endocrinol Y Nutr 62:e1–13. https://doi.org/10.1016/j.endonu.2014.05.005

Article  Google Scholar 

Zucchini S, Di Iorgi N, Pozzobon G, Pedicelli S, Parpagnoli M, Driul D et al (2022) Management of Childhood-onset craniopharyngioma in italy: A Multicenter, 7-Year Follow-up study of 145 patients. J Clin Endocrinol Metab 107:E1020–E1031. https://doi.org/10.1210/CLINEM/DGAB784

Article  PubMed  Google Scholar 

Boekhoff S, Bison B, Eveslage M, Sowithayasakul P, Müller HL (2019) Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007. Pituitary 22:532–541. https://doi.org/10.1007/S11102-019-00983-7

Article  PubMed  Google Scholar 

Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R et al (2016) Hormonal replacement in hypopituitarism in adults: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2016-2118

Article  PubMed  Google Scholar 

Müller HL, Merchant TE, Warmuth-Metz M, Martinez-Barbera JP, Puget S, Craniopharyngioma Nat Rev Dis Prim 2019;5. https://doi.org/10.1038/S41572-019-0125-9

Müller HL (2016) Preoperative staging in childhood craniopharyngioma: standardization as a first step towards improved outcome. Endocrine 51:1–3. https://doi.org/10.1007/S12020-015-0800-X

Article  PubMed  Google Scholar 

Sterkenburg AS, Hoffmann A, Gebhardt U, Warmuth-Metz M, Daubenbüchel AMM, Müller HL (2015) Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes. Neuro Oncol 17:1029–1038. https://doi.org/10.1093/NEUONC/NOV044

Article  PubMed  PubMed Central  Google Scholar 

Müller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U et al (2004) Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab 89:3298–3305. https://doi.org/10.1210/JC.2003-031751

Article  PubMed  Google Scholar 

Sowithayasakul P, Buschmann LK, Boekhoff S, Müller HL (2021) Cardiac remodeling in patients with childhood-onset craniopharyngioma—results of HIT-Endo and KRANIOPHARYNGEOM 2000/2007. Eur J Pediatr 180:1593–1602. https://doi.org/10.1007/S00431-020-03915-X

Article  PubMed  PubMed Central  Google Scholar 

Wijnen M, Van Den Olsson DS, Hammarstrand C, Van Der Janssen JAMJL et al (2018) Excess morbidity and mortality in patients with craniopharyngioma: A hospital-based retrospective cohort study. Eur J Endocrinol 178:93–102. https://doi.org/10.1530/EJE-17-0707

Article  CAS  PubMed  Google Scholar 

Verweij T, Slagboom TNA, Van Varsseveld NC, Drent ML, Van Bunderen CC (2021) Cardiovascular risk profile in growth hormone-treated adults with craniopharyngioma compared to non-functioning pituitary adenoma: A National cohort study. Eur J Endocrinol 185:793–801. https://doi.org/10.1530/EJE-21-0419

Article  CAS  PubMed  Google Scholar 

Bülow B, Attewell R, Hagmar L, Malmström P, Nordström C-H, Erfurth EM (1998) Postoperative prognosis in craniopharyngioma with respect to cardiovascular mortality, survival, and tumor recurrence. J Clin Endocrinol Metab 83:3897–3904. https://doi.org/10.1210/JCEM.83.11.5240

Article  PubMed  Google Scholar 

Wijnen M, Van Den Olsson DS, Hammarstrand C, Van Der Janssen JAMJL et al (2018) The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up. Eur J Endocrinol 178:11–22. https://doi.org/10.1530/EJE-17-0387

Article  CAS  PubMed  Google Scholar 

Meijneke RWH, Schouten-Van Meeteren AYN, De Boer NY, Van Zundert S, Van Trotsenburg PAS, Stoelinga F et al (2015) Hypothalamic obesity after treatment for craniopharyngioma: the importance of the home environment. J Pediatr Endocrinol Metab 28:59–63. https://doi.org/10.1515/JPEM-2014-0338

Article  PubMed  Google Scholar 

Roth CL, Scimia C, Shoemaker AH, Gottschalk M, Miller J, Yuan G et al (2024) Setmelanotide for the treatment of acquired hypothalamic obesity: a phase 2, open-label, multicentre trial. Lancet Diabetes Endocrinol 12:380–389. https://doi.org/10.1016/S2213-8587(24)00087-1

Article  CAS  PubMed  Google Scholar 

Huynh K, Klose M, Krogsgaard K, Drejer J, Byberg S, Madsbad S et al (2022) Randomized controlled trial of tesomet for weight loss in hypothalamic obesity. Eur J Endocrinol 187:687–700. https://doi.org/10.1530/EJE-21-0972

Article  Google Scholar 

Momin AA, Recinos MA, Cioffi G, Patil N, Soni P, Almeida JP et al (2021) Descriptive epidemiology of craniopharyngiomas in the united States. Pituitary 24:517–522. https://doi.org/10.1007/S11102-021-01127-6

Article  CAS  PubMed  Google Scholar 

Calandrelli R, D’Apolito G, Martucci M, Giordano C, Schiarelli C, Marziali G et al (2024) Topography and radiological variables as ancillary parameters for evaluating tissue Adherence, Hypothalamic–Pituitary Dysfunction, and recurrence in craniopharyngioma: an integrated multidisciplinary overview. Cancers (Basel) 16. https://doi.org/10.3390/CANCERS16142532

Mortini P, Losa M, Pozzobon G, Barzaghi R, Riva M, Acerno S et al (2011) Neurosurgical treatment of craniopharyngioma in adults and children: early and long-term results in a large case series - Clinical Article. J Neurosurg 114:1350–1359. https://doi.org/10.3171/2010.11.JNS10670

Article  PubMed  Google Scholar 

Gallotti AL, Barzaghi LR, Albano L, Medone M, Gagliardi F, Losa M et al (2022) Comparison between extended transsphenoidal and transcranial surgery for craniopharyngioma: focus on hypothalamic function and obesity. Pituitary 25:74–84. https://doi.org/10.1007/S11102-021-01171-2

Article  PubMed 

Comments (0)

No login
gif