Sex differences in the clinical presentation, management and long-term outcomes of pituitary tumors in children and adolescents

Maiter D, Chanson P, Constantinescu SM, Linglart A (2024) Diagnosis and management of pituitary adenomas in children and adolescents. Eur J Endocrinol 191(4):R55–R69

Article  CAS  PubMed  Google Scholar 

Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR et al (2024) Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations. Nat Rev Endocrinol 20(5):278–289

Article  PubMed  Google Scholar 

Raappana A, Koivukangas J, Ebeling T, Pirila T (2010) Incidence of pituitary adenomas in Northern Finland in 1992–2007. J Clin Endocrinol Metab 95(9):4268–4275

Article  CAS  PubMed  Google Scholar 

Gruppetta M, Mercieca C, Vassallo J (2013) Prevalence and incidence of pituitary adenomas: a population based study in Malta. Pituitary 16(4):545–553

Article  PubMed  Google Scholar 

Perry A, Graffeo CS, Marcellino C, Pollock BE, Wetjen NM, Meyer FB (2018) Pediatric Pituitary adenoma: case series, review of the literature, and a skull base treatment paradigm. J Neurol Surg B Skull Base 79(1):91–114

Article  PubMed  PubMed Central  Google Scholar 

Keil MF, Stratakis CA (2008) Pituitary tumors in childhood: update of diagnosis, treatment and molecular genetics. Expert Rev Neurother 8(4):563–574

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR et al (2024) Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: part 2, specific diseases. Nat Rev Endocrinol 20(5):290–309

Article  PubMed  Google Scholar 

Mindermann T, Wilson CB (1994) Age-related and gender-related occurrence of pituitary adenomas. Clin Endocrinol (Oxf) 41(3):359–364

Article  CAS  PubMed  Google Scholar 

Savage MO, Storr HL (2012) Pediatric Cushing’s disease: management issues. Indian J Endocrinol Metab 16(Suppl 2):S171–S175

Article  PubMed  PubMed Central  Google Scholar 

Lonser RR, Wind JJ, Nieman LK, Weil RJ, DeVroom HL, Oldfield EH (2013) Outcome of surgical treatment of 200 children with Cushing’s disease. J Clin Endocrinol Metab 98(3):892–901

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arasho BD, Schaller B, Sandu N, Zenebe G (2009) Gender-related differences in pituitary adenomas. Exp Clin Endocrinol Diabetes 117(10):567–572

Article  CAS  PubMed  Google Scholar 

Martinez de LaPiscina I, Portillo Najera N, Rica I, Gaztambide S, Webb SM, Santos A et al (2021) Clinical and genetic characteristics in patients under 30 years with sporadic pituitary adenomas. Eur J Endocrinol 185(4):485–496

Article  CAS  PubMed  Google Scholar 

Stratakis CA (2023) An update on, and genetics of refractory adenomas of childhood. Pituitary 26(3):281–287

Article  PubMed  Google Scholar 

Denes J, Korbonits M (2021) The clinical aspects of pituitary tumour genetics. Endocrine 71(3):663–674

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colao AP (2021) In: Feingold KA, RA; et al (eds) R. Pituitary Tumors in Childhood. MDText.com, Inc., Endotext

Kumar S, Sarathi V, Lila AR, Sehemby M, Memon SS, Karlekar M et al (2022) Giant prolactinoma in children and adolescents: a single-center experience and systematic review. Pituitary 25(6):819–30

Article  CAS  PubMed  Google Scholar 

Boukerrouni A, Cuny T, Anjou T, Raingeard I, Ferriere A, Grunenwald S et al (2023) Genetic testing in prolactinomas: a cohort study. Eur J Endocrinol 189(6):567–574

Article  CAS  PubMed  Google Scholar 

Salenave S, Ancelle D, Bahougne T, Raverot G, Kamenicky P, Bouligand J et al (2015) Macroprolactinomas in children and adolescents: factors associated with the response to treatment in 77 patients. J Clin Endocrinol Metab 100(3):1177–86

Article  CAS  PubMed  Google Scholar 

Fideleff HL, Boquete HR, Sequera A, Suarez M, Sobrado P, Giaccio A (2000) Peripubertal prolactinomas: clinical presentation and long-term outcome with different therapeutic approaches. J Pediatr Endocrinol Metab 13(3):261–267

Article  CAS  PubMed  Google Scholar 

Dzialach L, Sobolewska J, Zak Z, Respondek W, Witek P (2024) Prolactin-secreting pituitary adenomas: male-specific differences in pathogenesis, clinical presentation and treatment. Front Endocrinol (Lausanne) 15:1338345

Article  PubMed  PubMed Central  Google Scholar 

Colao A, Loche S, Cappa M, Di Sarno A, Landi ML, Sarnacchiaro F et al (1998) Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. J Clin Endocrinol Metab 83(8):2777–80

Article  CAS  PubMed  Google Scholar 

Chanson P, Maiter D (2019) The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new. Best Pract Res Clin Endocrinol Metab 33(2):101290

Article  PubMed  Google Scholar 

Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK et al (2023) Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement. Nat Rev Endocrinol 19(12):722–40

Article  PubMed  Google Scholar 

Delgrange E, Trouillas J, Maiter D, Donckier J, Tourniaire J (1997) Sex-related difference in the growth of prolactinomas: a clinical and proliferation marker study. J Clin Endocrinol Metab 82(7):2102–2107

CAS  PubMed  Google Scholar 

Maiter D, Delgrange E (2014) Therapy of endocrine disease: the challenges in managing giant prolactinomas. Eur J Endocrinol 170(6):R213–R227

Article  CAS  PubMed  Google Scholar 

Constantinescu SM, Nava CM, Chasseloup F, Alexopoulou O, Chanson P, Maiter D (2025) Menopause has a beneficial influence on the evolution of prolactinomas. A study of 99 patients. J Clin Endocrinol Metab 110(11):e3701–e8

Article  CAS  PubMed  Google Scholar 

Delgrange E, Vasiljevic A, Wierinckx A, Francois P, Jouanneau E, Raverot G et al (2015) Expression of estrogen receptor alpha is associated with prolactin pituitary tumor prognosis and supports the sex-related difference in tumor growth. Eur J Endocrinol 172(6):791–801

Article  CAS  PubMed  Google Scholar 

Trouillas J, Delgrange E, Wierinckx A, Vasiljevic A, Jouanneau E, Burman P et al (2019) Clinical, Pathological, and Molecular Factors of Aggressiveness in Lactotroph Tumours. Neuroendocrinology 109(1):70–76

Article  CAS  PubMed  Google Scholar 

Lodish MB, Keil MF, Stratakis CA (2018) Cushing’s syndrome in pediatrics: an update. Endocrinol Metab Clin North Am 47(2):451–462

Article  PubMed  PubMed Central  Google Scholar 

Ferrigno R, Hasenmajer V, Caiulo S, Minnetti M, Mazzotta P, Storr HL et al (2021) Paediatric Cushing’s disease: epidemiology, pathogenesis, clinical management and outcome. Rev Endocr Metab Disord 22(4):817–35

Article  PubMed  PubMed Central  Google Scholar 

Concepcion-Zavaleta MJ, Armas CD, Quiroz-Aldave JE, Garcia-Villasante EJ, Gariza-Solano AC, Durand-Vasquez MDC et al (2023) Cushing disease in pediatrics: an update. Ann Pediatr Endocrinol Metab 28(2):87–97

Article  PubMed  PubMed Central  Google Scholar 

Salcedo-Sifuentes JE, Shih R, Heaney AP, Bergsneider M, Wang MB, Donangelo I et al (2025) Cushing disease clinical phenotype and tumor behavior vary with age: diagnostic and perioperative implications. J Clin Endocrinol Metab 110(9):2595–604

Article  CAS  PubMed 

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