Metabolic syndrome in cushing’s syndrome patients: Does gender matter?

Ceccato F, Terzolo M, Gatto F, Cannavò S, Bianchi A, Isidori AM, Colao A, Ferone D, Aimaretti G, Pecori Giraldi F, Arnaldi G, Scaroni C (2025) Who and how to screen for cushing’s syndrome: the position statement of the Italian society of endocrinology. J Endocrinol Invest. https://doi.org/10.1007/s40618-025-02758-3

Article  PubMed  PubMed Central  Google Scholar 

Suntornlohanakul O, Ronchi CL, Arlt W, Prete A (2025) Sexual dimorphism in benign adrenocortical tumours. Eur J Endocrinol. https://doi.org/10.1093/ejendo/lvaf088

Article  PubMed  PubMed Central  Google Scholar 

Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA et al (2022) Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study. Lancet Diabetes Endocrinol. https://doi.org/10.1016/S2213-8587(22)00100-0

Article  PubMed  PubMed Central  Google Scholar 

Geer EB, Islam J, Buettner C (2014) Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism. Endocrinol Metab Clin North Am. https://doi.org/10.1016/j.ecl.2013.10.005

Article  PubMed  PubMed Central  Google Scholar 

Ferraù F, Korbonits M (2018) Metabolic syndrome in cushing’s syndrome patients. Front Horm Res. https://doi.org/10.1159/000486002

Article  PubMed  Google Scholar 

Ceccato F, Bavaresco A, Ragazzi E, Barbot M, Boscaro M, Basso D, Scaroni C, Antonelli G (2025) Clinical and biochemical data for the diagnosis of endogenous hypercortisolism: the cushingomic approach. J Clin Endocrinol Metab. https://doi.org/10.1210/clinem/dgae517

Article  PubMed  Google Scholar 

Braun LT, Vogel F, Zopp S, Marchant Seiter T, Rubinstein G, Berr CM, Künzel H, Beuschlein F, Reincke M (2022) Whom should we screen for Cushing syndrome? The endocrine society practice guideline recommendations 2008 revisited. J Clin Endocrinol Metab. https://doi.org/10.1210/clinem/dgac379

Article  PubMed  PubMed Central  Google Scholar 

Geer EB, Shen W, Gallagher D, Punyanitya M, Looker HC, Post KD, Freda PU (2010) MRI assessment of lean and adipose tissue distribution in female patients with cushing’s disease. Clin Endocrinol (Oxf). https://doi.org/10.1111/j.1365-2265.2010.03829.x

Article  PubMed  PubMed Central  Google Scholar 

Libuit LG, Karageorgiadis AS, Sinaii N, Nguyen May NM, Keil MF, Lodish MB, Stratakis CA (2015) A gender-dependent analysis of cushing’s disease in childhood: pre- and postoperative follow-up. Clin Endocrinol (Oxf). https://doi.org/10.1111/cen.12644

Article  PubMed  PubMed Central  Google Scholar 

Zilio M, Barbot M, Ceccato F, Camozzi V, Bilora F, Casonato A, Frigo AC, Albiger N, Daidone V, Mazzai L, Mantero F, Scaroni C (2014) Diagnosis and complications of cushing’s disease: gender-related differences. Clin Endocrinol (Oxf). https://doi.org/10.1111/cen.12299

Article  PubMed  Google Scholar 

Huan C, Qu Y, Ren Z (2014) Gender differences in presentation and outcome of patients with cushing’s disease in Han Chinese. Biomed Mater Eng. https://doi.org/10.3233/BME-141168

Article  PubMed  Google Scholar 

Pecori Giraldi F, Moro M, Cavagnini F, Study Group on the Hypothalamo-Pituitary-Adrenal Axis of the Italian Society of Endocrinology (2003) Gender-related differences in the presentation and course of Cushing’s disease. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2002-021518

Article  PubMed  Google Scholar 

Liu X, Zhu X, Zeng M, Zhuang Y, Zhou Y, Zhang Z, Yang Y, Wang Y, Ye H, Li Y (2015) Gender-specific differences in clinical profile and biochemical parameters in patients with cushing’s disease: a single center experience. Int J Endocrinol. https://doi.org/10.1155/2015/949620

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Mei X, Jian F, Ma Q, Chen X, Bian L, Sun Q (2014) Gender and magnetic resonance imaging classification-related differences in clinical and biochemical characteristics of cushing’s disease: a single-centre study. Chin Med J (Engl) 127(22):3948–3956

Article  PubMed  Google Scholar 

Geer EB, Shen W, Strohmayer E, Post KD, Freda PU (2012) Body composition and cardiovascular risk markers after remission of Cushing’s disease: a prospective study using whole-body MRI. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2011-3123

Article  PubMed  PubMed Central  Google Scholar 

Rockall AG, Sohaib SA, Evans D, Kaltsas G, Isidori AM, Monson JP, Besser GM, Grossman AB, Reznek RH (2003) Computed tomography assessment of fat distribution in male and female patients with cushing’s syndrome. Eur J Endocrinol. https://doi.org/10.1530/eje.0.1490561

Article  PubMed  Google Scholar 

Valassi E, Santos A, Yaneva M, Tóth M, Strasburger CJ, Chanson P, Wass JA, Chabre O, Pfeifer M, Feelders RA, Tsagarakis S, Trainer PJ, Franz H, Zopf K, Zacharieva S, Lamberts SW, Tabarin A, Webb SM, ERCUSYN Study Group (2011) The European registry on Cushing’s syndrome: 2-year experience. Baseline demographic and clinical characteristics. Eur J Endocrinol. https://doi.org/10.1530/EJE-11-0272

Article  PubMed  Google Scholar 

Giordano C, Guarnotta V, Pivonello R, Amato MC, Simeoli C, Ciresi A, Cozzolino A, Colao A (2013) Is diabetes in cushing’s syndrome only a consequence of hypercortisolism? Eur J Endocrinol. https://doi.org/10.1530/EJE-13-0754

Article  PubMed  Google Scholar 

Mancini T, Kola B, Mantero F, Boscaro M, Arnaldi G (2004) High cardiovascular risk in patients with Cushing’s syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol (Oxf). https://doi.org/10.1111/j.1365-2265.2004.02168.x

Article  PubMed  Google Scholar 

Padilla C, Stratakis CA, Tatsi C (2024) The phenotype of the pediatric patient with Cushing syndrome but without obesity. Eur J Endocrinol. https://doi.org/10.1093/ejendo/lvae114

Article  PubMed  PubMed Central  Google Scholar 

Broersen LHA, van Haalen FM, Kienitz T, Biermasz NR, Strasburger CJ, Dekkers OM, Pereira AM (2019) Sex differences in presentation but not in outcome for ACTH-Dependent cushing’s syndrome. Front Endocrinol (Lausanne). https://doi.org/10.3389/fendo.2019.00580

Article  PubMed  PubMed Central  Google Scholar 

Vicennati V, Garelli S, Rinaldi E, Di Dalmazi G, Pagotto U, Pasquali R (2014) Cross-talk between adipose tissue and the HPA axis in obesity and overt hypercortisolemic States. Horm Mol Biol Clin Investig. https://doi.org/10.1515/hmbci-2013-0068

Article  PubMed  Google Scholar 

Garrapa GG, Pantanetti P, Arnaldi G, Mantero F, Faloia E (2001) Body composition and metabolic features in women with adrenal incidentaloma or cushing’s syndrome. J Clin Endocrinol Metab. https://doi.org/10.1210/jcem.86.11.8059

Article  PubMed  Google Scholar 

Pirlich M, Biering H, Gerl H, Ventz M, Schmidt B, Ertl S, Lochs H (2002) Loss of body cell mass in cushing’s syndrome: effect of treatment. J Clin Endocrinol Metab. https://doi.org/10.1210/jcem.87.3.8321

Article  PubMed  Google Scholar 

Ragnarsson O, Glad CA, Bergthorsdottir R, Almqvist EG, Ekerstad E, Widell H, Wängberg B, Johannsson G (2015) Body composition and bone mineral density in women with cushing’s syndrome in remission and the association with common genetic variants influencing glucocorticoid sensitivity. Eur J Endocrinol. https://doi.org/10.1530/EJE-14-0747

Article  PubMed  Google Scholar 

Barahona MJ, Sucunza N, Resmini E, Fernández-Real JM, Ricart W, Moreno-Navarrete JM, Puig T, Farrerons J, Webb SM (2009) Persistent body fat mass and inflammatory marker increases after long-term cure of cushing’s syndrome. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2009-0766

Article  PubMed  Google Scholar 

Wagenmakers M, Roerink S, Gil L, Plantinga T, Smit J, Netea-Maier R, Hermus A (2015) Persistent centripetal fat distribution and metabolic abnormalities in patients in long-term remission of cushing’s syndrome. Clin Endocrinol (Oxf). https://doi.org/10.1111/cen.12639

Article  PubMed  Google Scholar 

Elbers JM, Asscheman H, Seidell JC, Frölich M, Meinders AE, Gooren LJ (1997) Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab. https://doi.org/10.1210/jcem.82.10.4284

Article  PubMed  Google Scholar 

Van Harmelen V, Reynisdottir S, Eriksson P, Thörne A, Hoffstedt J, Lönnqvist F, Arner P (1998) Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes. https://doi.org/10.2337/diabetes.47.6.913

Article  PubMed 

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