Triebel H, Castrop H (2024) The Renin angiotensin aldosterone system. Pflugers Arch 476:705–713. https://doi.org/10.1007/s00424-024-02908-1
Article CAS PubMed PubMed Central Google Scholar
Paul M, Poyan Mehr A, Kreutz R (2006) Physiology of local renin-angiotensin systems. Physiol Rev 86:747–803. https://doi.org/10.1152/physrev.00036.2005
Article CAS PubMed Google Scholar
Zhao J, Yang H, Chen B, Zhang R (2019) The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases. Int Immunopharmacol 72:258–263. https://doi.org/10.1016/j.intimp.2019.04.023
Article CAS PubMed Google Scholar
Chaves Moreira FR, de Oliveira TA, Ramos NE, Duarte Abreu MA, Simoes E, Silva AC (2021) The role of Renin angiotensin system in the pathophysiology of rheumatoid arthritis. Mol Biol Rep 48:6619–6629. https://doi.org/10.1007/s11033-021-06672-8
Paz Ocaranza M, Riquelme JA, García L, Jalil JE, Chiong M et al (2020) Counter-regulatory renin-angiotensin system in cardiovascular disease. Nat Rev Cardiol 17:116–129. https://doi.org/10.1038/s41569-019-0244-8
Bader M, Steckelings UM, Alenina N, Santos RAS, Ferrario CM (2024) Alternative renin-angiotensin system. Hypertension 81:964–976. https://doi.org/10.1161/HYPERTENSIONAHA.123.21364
Article CAS PubMed PubMed Central Google Scholar
Habib YH, Khattab M, Gowayed MA (2025) The renin–angiotensin system (RAS) and arthritic diseases: therapeutic potential for RAS inhibitors. Inflammopharmacology 33:5037–5047. https://doi.org/10.1007/s10787-025-01890-z
Article CAS PubMed Google Scholar
Qian Y, Zhang B, Nian F (2025) The association between rheumatoid arthritis and left ventricular diastolic dysfunction: pathogenesis, predictors and managements. Clin Exp Rheumatol 43:135–144. https://doi.org/10.55563/clinexprheumatol/kmmkj7
Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD (2011) Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 31:1409–1417. https://doi.org/10.1007/s00296-011-1999-3
Almutlaq M, Alamro AA, Alroqi F, Barhoumi T (2021) Classical and counter-regulatory renin–angiotensin system: potential key roles in COVID-19 pathophysiology. CJC Open 3:1060–1074. https://doi.org/10.1016/j.cjco.2021.04.004
Article PubMed PubMed Central Google Scholar
Kanugula AK, Kaur J, Batra J, Ankireddypalli AR, Velagapudi R (2023) Renin-angiotensin system: updated Understanding and role in physiological and pathophysiological States. Cureus 15:e40725. https://doi.org/10.7759/cureus.40725
Article PubMed PubMed Central Google Scholar
Pejler G, Rönnberg E, Waern I, Wernersson S (2010) Mast cell proteases: multifaceted regulators of inflammatory disease. Blood 115:4981–4990. https://doi.org/10.1182/blood-2010-01-257287
Article CAS PubMed Google Scholar
Nigrovic PA, Lee DM (2005) Mast cells in inflammatory arthritis. Arthritis Res Ther 7:1–11. https://doi.org/10.1186/ar1446
Article CAS PubMed Google Scholar
Loucks A, Maerz T, Hankenson K, Moeser A, Colbath A (2023) The multifaceted role of mast cells in joint inflammation and arthritis. Osteoarthritis Cartilage 31:567–575. https://doi.org/10.1016/j.joca.2023.01.005
Article CAS PubMed Google Scholar
Chang Y, Wei W (2015) Angiotensin II in inflammation, immunity and rheumatoid arthritis. Clin Exp Immunol 179:137–145. https://doi.org/10.1111/cei.12467
Article CAS PubMed PubMed Central Google Scholar
Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T et al (2002) Pivotal role of the Renin/prorenin receptor in angiotensin II production and cellular responses to Renin. J Clin Invest 109:1417–1427. https://doi.org/10.1172/jci14276
Article CAS PubMed PubMed Central Google Scholar
Wang B, Jie H, Wang S, Dong B, Zou Y (2023) The role of (pro)renin receptor and its soluble form in cardiovascular diseases. Front Cardiovasc Med 10:1086603. https://doi.org/10.3389/fcvm.2023.1086603
Article CAS PubMed PubMed Central Google Scholar
Haque R, Iuvone PM, He L, Choi KSC, Ngo A et al (2017) The MicroRNA-21 signaling pathway is involved in prorenin receptor (PRR)-induced VEGF expression in ARPE-19 cells under a hyperglycemic condition. Mol Vis 23:251–262 PMID:28465657
CAS PubMed PubMed Central Google Scholar
Domenig O, Manzel A, Grobe N, Königshausen E, Kaltenecker CC et al (2016) Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney. Sci Rep 6:33678. https://doi.org/10.1038/srep33678
Article CAS PubMed PubMed Central Google Scholar
Matucci-Cerinic M, Lombardi A, Leoncini G, Pignone A, Sacerdoti L et al (1993) Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation? Rheumatol Int 13:1–4. https://doi.org/10.1007/BF00290326
Article CAS PubMed Google Scholar
Lautner RQ, Villela DC, Fraga-Silva RA, Silva N, Verano-Braga T et al (2013) Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. Circ Res 112:1104–1111. https://doi.org/10.1161/circresaha.113.301077
Article CAS PubMed Google Scholar
Rukavina Mikusic NL, Silva MG, Erra Díaz FA, Pineda AM, Ferragut F et al (2024) Alamandine, a protective component of the renin-angiotensin system, reduces cellular proliferation and interleukin-6 secretion in human macrophages through MasR–MrgDR heteromerization. Biochem Pharmacol 229:116480. https://doi.org/10.1016/j.bcp.2024.116480
Article CAS PubMed Google Scholar
de Carvalho Santuchi M, Dutra MF, Vago JP, Lima KM, Galvão I et al (2019) Angiotensin-(1–7) and alamandine promote anti-inflammatory response in macrophages in vitro and in vivo. Mediators Inflamm 2019:2401081. https://doi.org/10.1155/2019/2401081
Wang Y, Del Borgo M, Lee HW, Baraldi D, Hirmiz B et al (2017) Anti-fibrotic potential of AT(2) receptor agonists. Front Pharmacol 8:564. https://doi.org/10.3389/fphar.2017.00564
Article CAS PubMed PubMed Central Google Scholar
Abadir PM, Foster DB, Crow M, Cooke CA, Rucker JJ et al (2011) Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A 108:14849–14854. https://doi.org/10.1073/pnas.1101507108
Article PubMed PubMed Central Google Scholar
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am J Physiol Heart Circ Physiol 281:H2337–H2365. https://doi.org/10.1152/ajpheart.2001.281.6.H2337
Article CAS PubMed Google Scholar
Çobankara V, Öztürk MA, Kiraz S, Ertenli I, Haznedaroglu I et al (2005) Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis. Rheumatol Int 25:285–291. https://doi.org/10.1007/s00296-004-0564-8
Article CAS PubMed Google Scholar
Wu Y, Li M, Zeng J, Feng Z, Yang J et al (2020) Differential expression of renin-angiotensin system-related components in patients with rheumatoid arthritis and osteoarthritis. Am J Med Sci 359:17–26. https://doi.org/10.1016/j.amjms.2019.10.014
Comments (0)