Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM et al (2018) Diffuse amyloid-β plaques, neurofibrillary tangles, and the impact of APOE in elderly persons’ brains lacking neuritic amyloid plaques. J Alzheimers Dis 64:1307–1324. https://doi.org/10.3233/JAD-180514
Article CAS PubMed PubMed Central Google Scholar
Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E et al (2017) Hippocampal alpha-synuclein in dementia with Lewy bodies contributes to memory impairment and is consistent with spread of pathology. J Neurosci 37:1675–1684. https://doi.org/10.1523/JNEUROSCI.3047-16.2016
Article CAS PubMed PubMed Central Google Scholar
Agrawal S, Yu L, Barnes LL, Bennett DA, Boyle PA, Schneider JA (2025) Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies. Acta Neuropathol 150:8. https://doi.org/10.1007/s00401-025-02916-0
Article PubMed PubMed Central Google Scholar
Aksman LM, Oxtoby NP, Scelsi MA, Wijeratne PA, Young AL, Alves IL et al (2023) A data-driven study of Alzheimer’s disease related amyloid and tau pathology progression. Brain 146:4935–4948. https://doi.org/10.1093/brain/awad232
Article PubMed PubMed Central Google Scholar
Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H et al (2008) Staging of neurofibrillary pathology in Alzheimer’s disease: a study of the BrainNet Europe Consortium. Brain Pathol 18:484–496. https://doi.org/10.1111/j.1750-3639.2008.00147.x
Article PubMed PubMed Central Google Scholar
Alafuzoff I, Libard S (2024) Ageing-related neurodegeneration and cognitive decline. Int J Mol Sci. https://doi.org/10.3390/ijms25074065
Article PubMed PubMed Central Google Scholar
Alexander GM, Farris S, Pirone JR, Zheng C, Colgin LL, Dudek SM (2016) Social and novel contexts modify hippocampal CA2 representations of space. Nat Commun 7:10300. https://doi.org/10.1038/ncomms10300
Article CAS PubMed PubMed Central Google Scholar
Almeida FC, Marx GA, Rohde SK, Gonzales MM, Maldonado-Diaz C, Hiya S et al (2025) Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies. Alzheimers Dement 21:e70575. https://doi.org/10.1002/alz.70575
Article CAS PubMed PubMed Central Google Scholar
Almeida FC, Santos A, Jesus T, Coelho A, Quintas-Neves M, Gauthreaux K et al (2025) Lewy body co-pathology in Alzheimer’s disease and primary age-related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns. Alzheimers Dement 21:e14191. https://doi.org/10.1002/alz.14191
Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR (1995) An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde.” Clin Anat 8:429–431. https://doi.org/10.1002/ca.980080612
Article CAS PubMed Google Scholar
Armstrong RA, Cairns NJ (2013) Spatial patterns of the tau pathology in progressive supranuclear palsy. Neurol Sci 34:337–344. https://doi.org/10.1007/s10072-012-1006-0
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42:631–639. https://doi.org/10.1212/wnl.42.3.631
Article CAS PubMed Google Scholar
Bancher C, Egensperger R, Kosel S, Jellinger K, Graeber MB (1997) Low prevalence of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant form of senile dementia. Acta Neuropathol 94:403–409. https://doi.org/10.1007/s004010050726
Article CAS PubMed Google Scholar
Bancher C, Jellinger KA (1994) Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects. Acta Neuropathol 88:565–570. https://doi.org/10.1007/BF00296494
Article CAS PubMed Google Scholar
Beach TG, Malek-Ahmadi M (2021) Alzheimer’s disease neuropathological comorbidities are common in the younger-old. J Alzheimers Dis 79:389–400. https://doi.org/10.3233/JAD-201213
Article CAS PubMed PubMed Central Google Scholar
Bell WR, An Y, Kageyama Y, English C, Rudow GL, Pletnikova O et al (2019) Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer’s disease. Alzheimers Dement 15:8–16. https://doi.org/10.1016/j.jalz.2018.07.215
Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW (2013) Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer’s disease. Neurobiol Aging 34:1653–1661. https://doi.org/10.1016/j.neurobiolaging.2012.11.024
Article CAS PubMed Google Scholar
Besser LM, Crary JF, Mock C, Kukull WA (2017) Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy. Neurology 89:1707–1715. https://doi.org/10.1212/WNL.0000000000004521
Article PubMed PubMed Central Google Scholar
Besser LM, Mock C, Teylan MA, Hassenstab J, Kukull WA, Crary JF (2019) Differences in cognitive impairment in primary age-related tauopathy versus Alzheimer disease. J Neuropathol Exp Neurol 78:219–228. https://doi.org/10.1093/jnen/nly132
Article CAS PubMed PubMed Central Google Scholar
Besson FL, La Joie R, Doeuvre L, Gaubert M, Mezenge F, Egret S et al (2015) Cognitive and brain profiles associated with current neuroimaging biomarkers of preclinical Alzheimer’s disease. J Neurosci 35:10402–10411. https://doi.org/10.1523/JNEUROSCI.0150-15.2015
Article CAS PubMed PubMed Central Google Scholar
Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD et al (2021) The second NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. J Neuropathol Exp Neurol 80:210–219. https://doi.org/10.1093/jnen/nlab001
Article CAS PubMed PubMed Central Google Scholar
Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J, Davis KL et al (1995) Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer’s disease. Arch Neurol 52:81–88. https://doi.org/10.1001/archneur.1995.00540250089017
Article CAS PubMed Google Scholar
Bouras C, Hof PR, Morrison JH (1993) Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett 153:131–135. https://doi.org/10.1016/0304-3940(93)90305-5
Article CAS PubMed Google Scholar
Boyle PA, Yu L, Nag S, Leurgans S, Wilson RS, Bennett DA et al (2015) Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology 85:1930–1936. https://doi.org/10.1212/WNL.0000000000002175
Article CAS PubMed PubMed Central Google Scholar
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259. https://doi.org/10.1007/BF00308809
Article CAS PubMed Google Scholar
Braak H, Del Tredici K (2014) Are cases with tau pathology occurring in the absence of Abeta deposits part of the AD-related pathological process? Acta Neuropathol 128:767–772. https://doi.org/10.1007/s00401-014-1356-1
Braak H, Del Tredici K (2015) N
Comments (0)