Body composition changes across a spectrum of hypothyroidism severity - a systematic review and meta-analysis

Mullur R, Liu Y-Y, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014. https://doi.org/10.1152/physrev.00030.2013.

Article  PubMed  PubMed Central  Google Scholar 

Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD. The molecular biology of thyroid hormone action. Ann N Y Acad Sci. 1995. https://doi.org/10.1111/j.1749-6632.1995.tb24843.x.

Article  PubMed  Google Scholar 

Rosenbaum M, Hirsch J, Murphy E, Leibel RL. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Am J Clin Nutr. 2000. https://doi.org/10.1093/ajcn/71.6.1421.

Article  PubMed  Google Scholar 

Chaker L, Bianco AC, Jonklaas J, Peeters RP. (2017). Hypothyroidism. Lancet (London, England). https://doi.org/10.1016/S0140-6736(17)30703-1

Gaitonde DY, Rowley KD, Sweeney LB. Hypothyroidism: an update. Am Fam Physician; 2012.

Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab. 2003. https://doi.org/10.1210/jc.2003-030398.

Article  PubMed  Google Scholar 

Johansen K, Hansen JM, Skovsted L. The Preferential role of Triiodothyronine in the regulation of basal metabolic rate in Hyper- and hypothyroidism. Acta Med Scand. 1978. https://doi.org/10.1111/j.0954-6820.1978.tb08454.x.

Article  PubMed  Google Scholar 

McAninch EA, Bianco AC. Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci. 2014. https://doi.org/10.1111/nyas.12374.

Article  PubMed  PubMed Central  Google Scholar 

Walton KW, Scott PJ, Dykes PW, Davies JW. (1965). The significance of alterations in serum lipids in thyroid dysfunction. II. Alterations of the metabolism and turnover of 131-I-low-density lipoproteins in hypothyroidism and thyrotoxicosis. Clinical science.

Pearce SHS, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, Wemeau J-L. 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J. 2013. https://doi.org/10.1159/000356507.

Article  PubMed  PubMed Central  Google Scholar 

Cai Y, Ren Y, Shi J. Blood pressure levels in patients with subclinical thyroid dysfunction: a meta-analysis of cross-sectional data. Hypertens Res. 2011. https://doi.org/10.1038/hr.2011.91.

Article  PubMed  Google Scholar 

Ding X, Zhao Y, Zhu C-Y, Wu L-P, Wang Y, Peng Z-Y, Shi B-Y. The association between subclinical hypothyroidism and metabolic syndrome: an update meta-analysis of observational studies. Endocr J. 2021. https://doi.org/10.1507/endocrj.EJ20-0796.

Article  PubMed  Google Scholar 

Maratou, E., Hadjidakis, D. J., Kollias, A., Tsegka, K., Peppa, M., Alevizaki, M.,… Dimitriadis, G. (2009). Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. European journal of endocrinology. https://doi.org/10.1530/EJE-08-0797.

Rodondi, N., den Elzen, W. P. J., Bauer, D. C., Cappola, A. R., Razvi, S., Walsh,J. P.,… Thyroid Studies Collaboration, for the. (2010). Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality. JAMA. https://doi.org/10.1001/jama.2010.1361.

Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, Jørgensen T. Small differences in thyroid function May be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab. 2005. https://doi.org/10.1210/jc.2004-2225.

Article  PubMed  Google Scholar 

Ríos-Prego M, Anibarro L, Sánchez-Sobrino P. Relationship between thyroid dysfunction and body weight: a not so evident paradigm. Int J Gen Med. 2019;12:299–304. https://doi.org/10.2147/IJGM.S206983.

Article  PubMed  PubMed Central  Google Scholar 

Karmisholt J, Andersen S, Laurberg P. Weight loss after therapy of hypothyroidism is mainly caused by excretion of excess body water associated with myxoedema. The J Clin Endocrinology Metabolism. 2011;96(1):E99–103. https://doi.org/10.1210/jc.2010-1521.

Article  CAS  Google Scholar 

Dahl M, Ohrt JD, Fonvig CE, Kloppenborg JT, Pedersen O, Hansen T, Holm JC. Subclinical hypothyroidism in Danish lean and obese children and adolescents. J Clin Res Pediatr Endocrinol. 2017;9(1):8–16. https://doi.org/10.4274/jcrpe.3319.

Article  PubMed  PubMed Central  Google Scholar 

van Hulsteijn LT, Pasquali R, Casanueva F, Haluzik M, Ledoux S, Monteiro MP, Dekkers OM. Prevalence of endocrine disorders in obese patients: systematic review and meta-analysis. Eur J Endocrinol. 2020;182(1):11–21. https://doi.org/10.1530/EJE-19-0666.

Article  CAS  PubMed  Google Scholar 

Garin MC, Arnold AM, Lee JS, Tracy RP, Cappola AR. Subclinical hypothyroidism, weight change, and body composition in the elderly: the cardiovascular health study. J Clin Endocrinol Metab. 2014;99(4):1220–6. https://doi.org/10.1210/jc.2013-3591.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moon, M. K., Lee, Y. J., Choi, S. H., Lim, S., Yang, E. J., Lim, J.-Y.,… Park, Y.J. (2010). Subclinical hypothyroidism has little influences on muscle mass or strength in elderly people. Journal of Korean Medical Science, 25(8), 1176–1181. https://doi.org/10.3346/jkms.2010.25.8.1176.

Aydogdu A, Karakas EY, Erkus E, Altıparmak İH, Savık E, Ulas T, Sabuncu T. Epicardial fat thickness and oxidative stress parameters in patients with subclinical hypothyroidism. Archives Med Science: AMS. 2017;13(2):383–9. https://doi.org/10.5114/aoms.2017.65479.

Article  CAS  PubMed Central  Google Scholar 

Sayin I, Erkan AF, Ekici B, Kutuk U, Corakci A, Tore HF. Thickening of the epicardial adipose tissue can be alleviated by thyroid hormone replacement therapy in patients with subclinical hypothyroidism. Kardiologia Polska. 2016;74(12):1492–8. https://doi.org/10.5603/KP.a2016.0053.

Article  PubMed  Google Scholar 

Stroup, D. F., Berlin, J. A., Morton, S. C., Olkin, I., Williamson, G. D., Rennie,D.,… Thacker, S. B. (2000). Meta-analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE)group. JAMA. https://doi.org/10.1001/jama.283.15.2008.

Moola S, Munn Z, Sears K, Sfetcu R, Currie M, Lisy K, Mu P. Conducting systematic reviews of association (etiology): the Joanna Briggs institute’s approach. Int J Evid Based Healthc. 2015. https://doi.org/10.1097/XEB.0000000000000064.

Article  PubMed  Google Scholar 

Wells, G. A., Wells, G., Shea, B., Shea, B., O’Connel, D., Peterson, J.,… Petersen.Judith, A. (2014). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Retrieved from https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

LeFevre ML. Screening for thyroid dysfunction: U.S. Preventive services task force recommendation statement. Ann Intern Med. 2015. https://doi.org/10.7326/M15-0483.

Article  PubMed  Google Scholar 

Xing D, Liu D, Li R, Zhou Q, Xu J. Factors influencing the reference interval of thyroid-stimulating hormone in healthy adults: A systematic review and meta-analysis. Clin Endocrinol. 2021;95(3):378–89. https://doi.org/10.1111/cen.14454.

Article  Google Scholar 

Calissendorff J, Falhammar H. To treat or not to treat subclinical hypothyroidism, what is the evidence?? Med (Kaunas Lithuania). 2020;56(1):40. https://doi.org/10.3390/medicina56010040.

Article  Google Scholar 

Cohen J. F tests on means in the analysis of variance and covariance. Elsevier. 1977. https://doi.org/10.1016/B978-0-12-179060-8.50013-X.

Article  Google Scholar 

Hedges LV. Distribution theory for glass’s estimator of effect size and related estimators. J Educational Stat. 1981. https://doi.org/10.2307/1164588.

Article  Google Scholar 

Gupta G, Itagappa M, Kumar P, Sharma R, Sharma P. (2015). A correlation between thyroid stimulating hormone and body mass index in women with subclinical hypothyroidism. Asian J Pharm Clin Res.

Gupta G, Gupta S, Gupta R. Hypercholesterolemia associated with subclinical hypothyroidism in NCR population. Indian J Public Health Research Development. 2016. https://doi.org/10.5958/0976-5506.2016.00083.8.

Article  Google Scholar 

Jha UC. (2021). To compare the thyroid profile, hs-CRP, and lipid profile in newly diagnosed hypothyroid adults to controls, as well as to compare the above parameters in subclinical and clinical hypothyroid instances. Eur J Mol Clin Med.

Khan, M. M., Yadav, P., Arowolo, S., Saidu, A., Olaniyi, S. A., Kaur, P.,… Alam,R. (2024). Association of Non-High-Density Lipoprotein Cholesterol With Cardiometabolic Risk Factors in Patients With Hypothyroidism. Cureus. https://doi.org/10.7759/cureus.64531.

Kini A, Hegde A, Jaseem T, Rao S, Pawar NM. Comparison of insulin sensitivity in subclinical and overt hypothyroidism. J Assoc Phys India. 2024. https://doi.org/10.59556/japi.72.0511.

Article  Google Scholar 

Kumar R, Rastogi P, Chetiwal R. Assessment of clinical and biochemical cardiac risk factors in patients with subclinical hypothyroidism: A Cross-sectional study. J Clin Diagn Res. 2024. https://doi.org/10.7860/JCDR/2024/67345.18893.

Article  Google Scholar 

Kumar R, Madhav R. (2020). A Case-control study to assess thyroid profile, hs-CRP and lipid profile in newly detected hypothyroid adults at tertiary care hospital. European Journal of Molecular & Clinical Medicine (EJMCM). Retrieved from https://ejmcm.com/uploads/paper/5f01efe617d5acea65a86acd08a8b351.pdf

Pangulari R, S, A., William E. (2013). Prevalence of metabolic syndrome and its components in women with subclinical hypothyroidism. Asian J Pharm Clin Res.

Patel AM, Khan S, Inam AMH, Alam R, Khan MM. Determination of serum zinc and phosphorus levels in patients with hypothyroidism. Biol Trace Elem Res. 2024. https://doi.org/10.1007/s12011-023-03905-8.

Article  PubMed  Google Scholar 

Roy A, Banerjee J, Mukhopapadhyay B, Bhar D. Assessment of cardiac autonomic neuropathy in subclinical hypothyroidism using Short-term heart rate variability: A Cross-sectional study. J Clin Diagn Res. 2024. https://doi.org/10.7860/JCDR/2024/72985.19985.

Article  Google Scholar 

Singh M, Narayan J, Thakur R, Bhattacharya S, Sonkar SK, Ali W. Association of stress and primary hypothyroidism. J Family Med Prim Care. 2024. https://doi.org/10.4103/jfmpc.jfmpc_845_23.

Article 

Comments (0)

No login
gif