JAPAN NCAC (2019) Quality survey of health food tablets and capsules - they might look like pharmaceutical products, but actually not! https://www.kokusen.go.jp/e-hello/news/data/n-20190801_1.html

Goda Y (2022) Regulatory science of natural products. J Nat Med 76(4):732–747. https://doi.org/10.1007/s11418-022-01639-w

Article  PubMed  PubMed Central  Google Scholar 

Higano T, Okamoto H, Uetake A, Aketo T, Hakamatsuka T (2009) An analysis of anthocyanins and anthocyanidins in the bilberry health foods. Jpn J Food Chem Saf 16:60–65. https://doi.org/10.18891/jjfcs.16.2_60

Article  CAS  Google Scholar 

Kakigi Y, Hakamatsuka T, Icho T, Goda Y, Mochizuki N (2012) Comprehensive analysis of flavonols in Ginkgo biloba products by ultra-high-performance liquid chromatography coupled with ultra-violet detection and time-of-flight mass spectrometry. Biosci Biotechnol Biochem 76(5):1003–1007. https://doi.org/10.1271/bbb.110873

Article  CAS  PubMed  Google Scholar 

Kamakura H (2010) The source plants and the chemical composition of the passion flower products available as dietary supplements. Jpn J Food Chem Saf 17:198–206. https://doi.org/10.18891/jjfcs.17.3_198

Article  CAS  Google Scholar 

Maruyama T, Kawamura M, Kikura-Hanajiri R, Goda Y (2014) Botanical origin of dietary supplements labeled as “Kwao Keur”, a folk medicine from Thailand. J Nat Med 68(1):220–224. https://doi.org/10.1007/s11418-013-0779-7

Article  CAS  PubMed  Google Scholar 

Masada S, Takahashi Y, Goda Y, Hakamatsuka T (2016) Qualitative and quantitative evaluation of drug and health food products containing red vine leaf extracts on the Japanese market. Chem Pharm Bull 64(9):1275–1280. https://doi.org/10.1248/cpb.c16-00164

Article  CAS  Google Scholar 

Masada-Atsumi S, Kumeta Y, Takahashi Y, Hakamatsuka T, Goda Y (2014) Evaluation of the botanical origin of black cohosh products by genetic and chemical analyses. Biol Pharm Bull 37(3):454–460. https://doi.org/10.1248/bpb.b13-00844

Article  CAS  PubMed  Google Scholar 

Sogame M, Naraki Y, Sasaki T, Seki M, Yokota K, Masada S, Hakamatsuka T (2019) Quality assessment of medicinal product and dietary supplements containing Vitex agnus-castus by HPLC fingerprint and quantitative analyses. Chem Pharm Bull 67:527–533. https://doi.org/10.1248/cpb.c18-00725

Article  CAS  Google Scholar 

Sato-Masumoto N, Masada S, Takahashi S, Terasaki S, Yokota Y, Hakamatsuka T, Goda Y (2015) Disintegration test of health food products containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese market. Medicines 2(2):47–54. https://doi.org/10.3390/medicines2020047

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asgarshirazi M, Shariat M, Dalili H (2015) Comparison of the effects of pH-dependent peppermint oil and synbiotic lactol (bacillus coagulans + fructooligosaccharides) on childhood functional abdominal pain: a randomized placebo-controlled study. Iran Red Crescent Med J 17(4):e23844. https://doi.org/10.5812/ircmj.17(4)2015.23844

Article  PubMed  PubMed Central  Google Scholar 

Capanni M, Surrenti E, Biagini M, Milani S, Surrenti C, Galli A (2005) Efficacy of peppermint oil in the treatment of irritable bowel syndrome: a randomized, controlled trial. Gazz Med Ital Arch S 164(2):119–126

Google Scholar 

Cappello G, Spezzaferro M, Grossi L, Manzoli L, Marzio L (2007) Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 39(6):530–536. https://doi.org/10.1016/j.dld.2007.02.006

Article  CAS  PubMed  Google Scholar 

Kline RM, Kline JJ, Di Palma J, Barbero GJ (2001) Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 138(1):125–128. https://doi.org/10.1067/mpd.2001.109606

Article  CAS  PubMed  Google Scholar 

Liu JH, Chen GH, Yeh HZ, Huang CK, Poon SK (1997) Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 32(6):765–768. https://doi.org/10.1007/BF02936952

Article  CAS  PubMed  Google Scholar 

Merat S, Khalili S, Mostajabi P, Ghorbani A, Ansari R, Malekzadeh R (2010) The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig Dis Sci 55(5):1385–1390. https://doi.org/10.1007/s10620-009-0854-9

Article  CAS  PubMed  Google Scholar 

Committee on Herbal Medicinal Products (2020) Assessment report on Mentha x piperita L., folium and aetheroleum. Final-Revision 1. European Medicines Agency, Amsterdam

Committee on Herbal Medicinal Products (2020) European Union herbal monograph on Mentha x piperita L., aetheroleum. Final-Revision 1. European Medicines Agency, Amsterdam

Matsueda K, Fukudo S, Ogishima M, Naito Y, Nakamura S (2024) Efficacy and safety of peppermint oil for the treatment in Japanese patients with irritable bowel syndrome: a prospective, open-label, and single-arm study. Biopsychosoc Med 18(1):3. https://doi.org/10.1186/s13030-024-00302-y

Article  PubMed  PubMed Central  Google Scholar 

Lawrence BM (2006) Mint: the genus Mentha. CRC Press, Florida

Google Scholar 

Spencer JS, Dowd E, Faas W (1997) The genuineness of two mint essential oils. Perfum Flavorist 22:37–45

CAS  Google Scholar 

Minister of Health, Labour and Welfare (2021) Mentha Oil. In: Japanese Pharmacopoeia 18th edition. Ministry of Health, Labour and Welfare, Tokyo, pp 2072–2073

European Directorate for the Quality of Medicines & HealthCare (2019) Peppermint oil 0405. In: European Pharmacopoeia 9.7. EDQM Council of Europe, Strasbourg, pp 6552–6553

European Directorate for the Quality of Medicines & HealthCare (2017) Mint oil, partly dementholised 1838. In: European Pharmacopoeia 9.3. EDQM Council of Europe, Strasbourg, pp 1443–1444

Medicines and Healthcare products Regulatory Agency (2023) Peppermint Oil Gastro-resistant Capsules. In: British Pharmacopoeia, vol 4. 2023. The Stationery Office, Norwich, pp 423–424

Committee on Herbal Medicinal Products (2016) Public statement on the use of herbal medicinal products containing pulegone and menthofuran. Final. European Medicines Agency, Amsterdam

Yu S, Chen Y, Zhang L, Shan M, Tang Y, Ding A (2011) Quantitative comparative analysis of the bio-active and toxic constituents of leaves and spikes of Schizonepeta tenuifolia at different harvesting times. Int J Mol Sci 12(10):6635–6644. https://doi.org/10.3390/ijms12106635

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minister of Health, Labour and Welfare (2021) Disintegration Test. In: Japanese Pharmacopoeia 18th edition. Ministry of Health, Labour and Welfare, Tokyo, pp 169–170

European Directorate for the Quality of Medicines & HealthCare (2023) Disintegration of tablets and capsules (2.9.1.) 20901. In: European Pharmacopoeia 10.6. EDQM Council of Europe, Strasbourg, pp 5995–5997

Hawrył MA, Skalicka-Woźniak K, Świeboda R, Niemiec M, Stępak K, Waksmundzka-Hajnos M, Hawrył A, Szymczak G (2015) GC-MS fingerprints of mint essential oils. Open Chem. https://doi.org/10.1515/chem-2015-0148

Article  Google Scholar 

Committee on Herbal Medicinal products (2020) Assessment report on Thymus vulgaris L., Thymus zygis L., aetheroleum. Final-Revision 1. European Medicines Agency, Amsterdam

Committee on Herbal Medicinal products (2010) Assessment report on Rosmarinus officinalis L., aetheroleum and Rosmarinus officinalis L., folium. Final. European Medicines Agency, Amsterdam

Committee on Herbal Medicinal products (2010) Assessment report on Zingiber officinale Roscoe, rhizoma. Final. European Medicines Agency, Amsterdam

Committee on Herbal Medicinal products (2024) Assessment report on Foeniculum vulgare Miller subsp. vulgare var. vulgare, aetheroleum. Final-Revision 1. European Medicines Agency, Amsterdam

EFSA Feedap Panel, Bampidis V, Azimonti G, Bastos ML, Christensen H, Kouba M, Fašmon Durjava M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Galobart J, Manini P, Pizzo F, Dusemund B (2021) Scientific Opinion on the safety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl). EFSA J 19(4):e06548. https://doi.org/10.2903/j.efsa.2021.6548

Article  CAS  Google Scholar 

EFSA Feedap Panel, Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Schrenk D, Westendorf J, Manini P, Pizzo F, Dusemund B (2022) Scientific Opinion on the safety and efficacy of a feed additive consisting of an essential oil from Cinnamomum cassia (L) J Presl (cassia leaf oil) for use in all animal species (FEFANA asbl). EFSA J 20(10):e07600. https://doi.org/10.2903/j.efsa.2022.7600

Article  CAS  Google Scholar 

Committee on Herbal Medicinal Products (2015) Assessment report on Carum carvi L., fructus and Carum carvi L., aetheroleum. Final. European Medicines Agency, Amsterdam

EFSA Feedap Panel, Bampidis V, Azimonti G, de Lourdes BM, Christensen H, Kouba M, Kos Durjava M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa R, Woutersen R, Brantom P, Chesson A, Kolar B, Beelen PV, Westendorf J, Gregoretti L, Manini P, Dusemund B (2019) Scientific Opinion on the safety and efficacy of an essential oil from Elettaria cardamomum (L.) Maton when used as a sensory additive in feed for all animal species. EFSA J 17(6):e05721. https://doi.org/10.2903/j.efsa.2019.5721

Article  CAS  Google Scholar 

Goudjil MB, Zighmi S, Hamada D, Mahcene Z, Bencheikh SE, Ladjel S (2020) Biological activities of essential oils extracted from Thymus capitatus (Lamiaceae). S Afr J Bot 128:274–282. https://doi.org/10.1016/j.sajb.2019.11.020

Article  CAS  Google Scholar 

Zheljazkov VD, Cerven V, Cantrell CL, Ebelhar WM, Horgan T (2009) Effect of nitrogen, location, and harvesting stage on peppermint productivity, oil content, and oil composition. HortSci horts 44(5):1267–1270. https://doi.org/10.21273/hortsci.44.5.1267

Article  Google Scholar 

Akhtar MQ, Qamar N, Yadav P, Kulkarni P, Kumar A, Shasany AK (2017) Comparative glandular trichome transcriptome-based gene characterization reveals reasons for differential (-)-menthol biosynthesis in Mentha species. Physiol Plantarum 160(2):128–141. https://doi.org/10.1111/ppl.12550

Article  CAS  Google Scholar 

Croteau RB, Davis EM, Ringer KL, Wildung MR (2005) (−)-Menthol biosynthesis and molecular genetics. Naturwissenschaften 92(12):562–577. https://doi.org/10.1007/s00114-005-0055-0

Article  CAS