Englund M (2023) Osteoarthritis, part of life or a curable disease? A bird’s-eye view. J Intern Med 293:681–693
Abdel-Aziz MA, Ahmed HMS, El-Nekeety AA, Abdel-Wahhab MA (2021) Osteoarthritis complications and the recent therapeutic approaches. Inflammopharmacology 29:1653–1667
Loughlin J (2022) Translating osteoarthritis genetics research: challenging times ahead. Trends Mol Med 28:176–182
Brophy RH, Fillingham YA (2022) AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition. J Am Acad Orthop Surg, 30:e721–e729
Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I (2018) Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol 71–72:40–50
PubMed PubMed Central Google Scholar
Rezuş E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezuş C (2021) From pathogenesis to therapy in knee osteoarthritis: bench-to-bedside. Int J Mol Sci 22(5):2697
PubMed PubMed Central Google Scholar
Goldenberg DL, Egan MS, Cohen AS (1982) Inflammatory synovitis in degenerative joint disease. J Rheumatol 9:204–209
Liu F, Lu Y, Wang X, Sun S, Pan H, Wang M, Wang Z, Zhang W, Ma S, Sun G, Chu Q, Wang S, Qu J, Liu GH (2023) Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling. Protein Cell 15(6):441–459
Nanus DE, Badoume A, Wijesinghe SN, Halsey AM, Hurley P, Ahmed Z, Botchu R, Davis ET, Lindsay MA, Jones SW (2021) Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets. EBioMedicine 72:103618
PubMed PubMed Central Google Scholar
Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D, Bai X (2018) Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis 77:1524–1534
Locati M, Curtale G, Mantovani A (2020) Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol 15:123–147
Lambert C, Zappia J, Sanchez C, Florin A, Dubuc JE, Henrotin Y (2020) The damage-associated molecular patterns (DAMPs) as potential targets to treat osteoarthritis: perspectives from a review of the literature. Front Med (Lausanne) 7:607186
Semenistaja S, Skuja S, Kadisa A, Groma V (2023) Healthy and osteoarthritis-affected joints facing the cellular crosstalk. Int J Mol Sci 24(4):4120
CAS PubMed PubMed Central Google Scholar
Yoshida S, Nishitani K, Yoshitomi H, Kuriyama S, Nakamura S, Fujii T, Saito M, Kobori Y, Murakami A, Murata K, Ito H, Ueno H, Matsuda S (2023) Knee alignment correction by high tibial osteotomy reduces symptoms and synovial inflammation in knee osteoarthritis accompanied by macrophage phenotypic change from M1 to M2. Arthritis Rheumatol 75:950–960
Xie JW, Wang Y, Xiao K, Xu H, Luo ZY, Li L, Pei FX, Kraus VB, Huang ZY (2021) Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization. Osteoarthritis Cartilage 29:1048–1059
Sun Z, Liu K, Liang C, Wen L, Wu J, Liu X, Li X (2024) Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies. Phytother Res 38:3660–3694
Zhao L, Jin L, Yang B (2023) Diosmetin alleviates S. aureus-induced mastitis by inhibiting SIRT1/GPX4 mediated ferroptosis. Life Sci 331:122060
Choi J, Lee DH, Park SY, Seol JW (2019) Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer. Biomed Pharmacother 117:109091
Guo G, Dong J (2022) Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway. Bioengineered 13:11072–11081
CAS PubMed PubMed Central Google Scholar
Ding H, Ding H, Mu P, Lu X, Xu Z (2023) Diosmetin inhibits subchondral bone loss and indirectly protects cartilage in a surgically-induced osteoarthritis mouse model. Chem Biol Interact 370:110311
Zhao S, Liu Y, Wang J, Wen Y, Wu B, Yang D, Wang G, Xiu G, Ling B, Du D, Xu J (2023) ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A. Int Immunopharmacol 120:110390
Shi Y, Hu X, Cheng J, Zhang X, Zhao F, Shi W, Ren B, Yu H, Yang P, Li Z, Liu Q, Liu Z, Duan X, Fu X, Zhang J, Wang J, Ao Y (2019) A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nat Commun 10:1914
PubMed PubMed Central Google Scholar
Qiu M, Cheng L, Xu J, Jin M, Yuan W, Ge Q, Zou K, Chen J, Huang Y, Li J, Zhu L, Xu B, Zhang C, Jin H, Wang P (2024) Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis. Life Sci 343:122536
Glasson SS, Chambers MG, Van Den Berg WB, Little CB (2010) The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 18(Suppl 3):S17–S23
Su W, Zheng X, Zhou H, Yang S, Zhu X (2023) Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro. Mol Immunol 159:46–57
Chen B, Wang L, Xie D, Wang Y (2024) Exploration and breakthrough in the mode of chondrocyte death - a potential new mechanism for osteoarthritis. Biomed Pharmacother 170:115990
Shumnalieva R, Kotov G, Ermencheva P, Monov S (2023) Pathogenic mechanisms and therapeutic approaches in obesity-related knee osteoarthritis. Biomedicines 12(1):9
PubMed PubMed Central Google Scholar
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H (2021) Engeletin protects against TNF-α-induced apoptosis and reactive oxygen species generation in chondrocytes and alleviates osteoarthritis in vivo. J Inflamm Res 14:745–760
PubMed PubMed Central Google Scholar
Li C, Ouyang Z, Huang Y, Lin S, Li S, Xu J, Liu T, Wu J, Guo P, Chen Z, Wu H, Ding Y (2023) NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages. Arthritis Res Ther 25:249
CAS PubMed PubMed Central Google Scholar
Lee H, Sung J, Kim Y, Jeong HS, Lee J (2020) Inhibitory effect of diosmetin on inflammation and lipolysis in coculture of adipocytes and macrophages. J Food Biochem 44:e13261
Chen Y, Wang Y, Liu M, Zhou B, Yang G (2020) Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways. Phytother Res 34:1310–1319
Salminen A (2023) The role of immunosuppressive myofibroblasts in the aging process and age-related diseases. J Mol Med (Berl) 101:1169–1189
Rim YA, Ju JH (2020) The role of fibrosis in osteoarthritis progression. Life (Basel) 11(1):3
Scanzello CR, Goldring SR (2012) The role of synovitis in osteoarthritis pathogenesis. Bone 51:249–257
CAS PubMed PubMed Central Google Scholar
Zhang Y, Ji Q (2023) Macrophage polarization in osteoarthritis progression: a promising therapeutic target. Front Cell Dev Biol 11:1269724
PubMed PubMed Central Google Scholar
Li H, Yuan Y, Zhang L, Xu C, Xu H, Chen Z (2023) Reprogramming macrophage polarization, depleting ros by astaxanthin and thioketal-containing polymers delivering rapamycin for osteoarthritis treatment. Adv Sci (Weinh), e2305363
Pang L, Jin H, Lu Z, Xie F, Shen H, Li X, Zhang X, Jiang X, Wu L, Zhang M, Zhang T, Zhai Y, Zhang Y, Guan H, Su J, Li M, Gao J (2023) Treatment with mesenchymal stem cell-derived nanovesicle-containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and macrophage polarization. Adv Healthc Mater 12:e2300315
Ji X, Du W, Che W, Wang L, Zhao L (2023) Apigenin inhibits the progression of osteoarthritis by mediating macrophage polarization. Molecules 28(7):2915
CAS PubMed PubMed Central Google Scholar
Shen X, Qin J, Wei Z, Liu F (2023) Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis. Biomed Pharmacother 167:115488
Comments (0)