Armstrong DG, Tan T-W, Boulton AJM, Bus SA. Diabet Foot Ulcers Jama. 2023;330(1):62–75.

CAS  Google Scholar 

Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736–43.

PubMed  Google Scholar 

Bakker K, Apelqvist J, Lipsky BA, Van Netten JJ. The 2015 IWGDF guidance documents on prevention and management of foot problems in diabetes: development of an evidence-based global consensus. Diabetes Metab Res Rev. 2016;32(Suppl 1):2–6.

PubMed  Google Scholar 

Donegan RJ, Schmidt BM, Blume PA. An overview of factors maximizing successful split-thickness skin grafting in diabetic wounds. Diabet Foot Ankle. 2014;5(1).

Holl J, Kowalewski C, Zimek Z, Fiedor P, Kaminski A, Oldak T, et al. Chronic diabetic wounds and their treatment with skin substitutes. Cells. 2021;10(3):655.

CAS  PubMed  PubMed Central  Google Scholar 

Reiss MJ, Han YP, Garcia E, Goldberg M, Yu H, Garner WL. Matrix metalloproteinase-9 delays wound healing in a murine wound model. Surgery. 2010;147(2):295–302.

PubMed  Google Scholar 

Theocharidis G, Thomas BE, Sarkar D, Mumme HL, Pilcher WJR, Dwivedi B, et al. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13(1):181.

CAS  PubMed  PubMed Central  Google Scholar 

Ojeh N, Pastar I, Tomic-Canic M, Stojadinovic O. Stem cells in skin regeneration, wound healing, and their clinical applications. Int J Mol Sci. 2015;16(10):25476–501.

CAS  PubMed  PubMed Central  Google Scholar 

Morgun EI, Vorotelyak EA. Epidermal stem cells in hair follicle cycling and skin regeneration: A view from the perspective of inflammation. Front Cell Dev Biology. 2020;8:581697.

Google Scholar 

den Dekker A, Davis FM, Kunkel SL, Gallagher KA. Targeting epigenetic mechanisms in diabetic wound healing. Transl Res. 2019;204:39–50.

Google Scholar 

Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44(3):450–62.

CAS  PubMed  PubMed Central  Google Scholar 

Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. Science. 2017;356(6342):1026–30. 54– 12.

CAS  PubMed  Google Scholar 

Gonzalez AC, Costa TF, Andrade ZA, Medrado AR. Wound healing-A literature review. Bras Dermatol. 2016;91(5):614–20.

Google Scholar 

Tracy LE, Minasian RA, Caterson EJ. Extracellular matrix and dermal fibroblast function in the healing wound. Adv Wound Care (New Rochelle). 2016;5(3):119–36.

PubMed  Google Scholar 

Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014;15(12):786–801.

CAS  PubMed  PubMed Central  Google Scholar 

Fremder M, Kim SW, Khamaysi A, Shimshilashvili L, Eini-Rider H, Park IS, et al. A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state. Cell Rep. 2021;36(6):109521.

CAS  PubMed  Google Scholar 

Li X, Xie L, Qu X, Zhao B, Fu W, Wu B, et al. GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses. FASEB J. 2020;34(10):13091–105.

CAS  PubMed  Google Scholar 

Li D, Zhang L, He Y, Zhou T, Cheng X, Huang W, et al. Novel histone post-translational modifications in diabetes and complications of diabetes: the underlying mechanisms and implications. Biomed Pharmacother. 2022;156:113984.

CAS  PubMed  Google Scholar 

Chen H, Jin C, Xie L, Wu J. Succinate as a signaling molecule in the mediation of liver diseases. Biochim Et Biophys Acta (BBA)-Molecular Basis Disease. 2024;1870(2):166935.

CAS  Google Scholar 

Mills E, O’Neill LAJ. Succinate: a metabolic signal in inflammation. Trends Cell Biol. 2014;24(5):313–20.

CAS  PubMed  Google Scholar 

Littlewood-Evans A, Sarret S, Apfel V, Loesle P, Dawson J, Zhang J, et al. GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. J Exp Med. 2016;213(9):1655–62.

CAS  PubMed  PubMed Central  Google Scholar 

Trauelsen M, Hiron TK, Lin D, Petersen JE, Breton B, Husted AS, et al. Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling. Cell Rep. 2021;35(11):109246.

CAS  PubMed  Google Scholar 

Keiran N, Ceperuelo-Mallafré V, Calvo E, Hernández-Alvarez MI, Ejarque M, Núñez-Roa C, et al. SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Nat Immunol. 2019;20(5):581–92.

CAS  PubMed  Google Scholar 

Sangineto M, Ciarnelli M, Cassano T, Radesco A, Moola A, Bukke VN, et al. Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in alzheimer’s disease. Redox Biol. 2023;66:102846.

CAS  PubMed  PubMed Central  Google Scholar 

Guo Y, Xie C, Li X, Yang J, Yu T, Zhang R, et al. Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nat Commun. 2017;8(1):15621.

CAS  PubMed  PubMed Central  Google Scholar 

Ang LP-K, Do TP, Thein ZM, Reza HM, Tan XW, Yap C, et al. Ex vivo expansion of conjunctival and limbal epithelial cells using cord blood Serum–Supplemented culture medium. Invest Opthalmology Visual Sci. 2011;52(9):6138–47.

CAS  Google Scholar 

Sigurdsson V, Hilmarsdottir B, Sigmundsdottir H, Fridriksdottir AJ, Ringnér M, Villadsen R, et al. Endothelial induced EMT in breast epithelial cells with stem cell properties. PLoS ONE. 2011;6(9):e23833.

CAS  PubMed  PubMed Central  Google Scholar 

Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835–70.

CAS  PubMed  Google Scholar 

Chmielowiec J, Borowiak M, Morkel M, Stradal T, Munz B, Werner S, et al. c-Met is essential for wound healing in the skin. J Cell Biol. 2007;177(1):151–62.

CAS  PubMed  PubMed Central  Google Scholar 

Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, et al. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing. Cell Rep Med. 2023;4(8):101129.

CAS  PubMed  PubMed Central  Google Scholar 

Dam DHM, Wang X-Q, Sheu S, Vijay M, Shipp D, Miller L, et al. Ganglioside GM3 mediates Glucose-Induced suppression of IGF-1 Receptor–Rac1 activation to inhibit keratinocyte motility. J Invest Dermatology. 2017;137(2):440–8.

CAS  Google Scholar 

Zhang S, Ke Z, Yang C, Zhou P, Jiang H, Chen L, et al. High glucose causes distinct expression patterns of primary human skin cells by RNA sequencing. Front Endocrinol. 2021;12:603645.

Google Scholar 

Zhao J, Yang S, Shu B, Chen L, Yang R, Xu Y, et al. Transient high glucose causes persistent vascular dysfunction and delayed wound healing by the DNMT1-Mediated Ang-1/NF-κB pathway. J Invest Dermatology. 2021;141(6):1573–84.

CAS  Google Scholar 

Kao JK, Wang SC, Ho LW, Huang SW, Lee CH, Lee MS, et al. M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload. Ann Hematol. 2020;99(3):431–41.

CAS  PubMed  Google Scholar 

Liu S, Zhang H, Li Y, Zhang Y, Bian Y, Zeng Y, et al. S100A4 enhances protumor macrophage polarization by control of PPAR-gamma-dependent induction of fatty acid oxidation. J Immunother Cancer. 2021;9(6):e002548.

PubMed  PubMed Central  Google Scholar 

Paschalidi P, Gkouveris I, Soundia A, Kalfarentzos E, Vardas E, Georgaki M, et al. The role of M1 and M2 macrophage polarization in progression of medication-related osteonecrosis of the jaw. Clin Oral Investig. 2021;25(5):2845–57.

PubMed  Google Scholar 

Munoz-Rojas AR, Kelsey I, Pappalardo JL, Chen M, Miller-Jensen K. Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells. Nat Commun. 2021;12(1):301.

CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Pan H, Xie X, Zhang J, Wang Y, Yang G. Inhibiting succinate dehydrogenase by dimethyl Malonate alleviates brain damage in a rat model of cardiac arrest. Neuroscience. 2018;393:24–32.

CAS  PubMed  Google Scholar 

Hauck S, Zager P, Halfter N, Wandel E, Torregrossa M, Kakpenova A, et al. Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity. Bioact Mater. 2021;6(12):4342–59.

CAS  PubMed  PubMed Central  Google Scholar 

Subhan BS, Kwong J, Kuhn JF, Monas A, Sharma S, Rabbani PS. Amniotic fluid-derived multipotent stromal cell