Clark A, Tate B, Urban B, Schroeder R, Gennuso S, Ahmadzadeh S, McGregor D, Girma B, Shekoohi S, Kaye AD. Bupropion-mediated effects on depression, attention deficit hyperactivity disorder, and smoking cessation. Health Psychol Res. 2023;1(11):81043. https://doi.org/10.52965/001c.81043.

Article  Google Scholar 

Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S. A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor. Primary Care Companion J Clin Psychiatry. 2004;6(4):159–66. https://doi.org/10.4088/pcc.v06n0403.

Article  PubMed  PubMed Central  Google Scholar 

Connarn JN, Zhang X, Babiskin A, Sun D. Metabolism of bupropion by carbonyl reductases in liver and intestine. Drug Metab Dispos. 2015Jul;43(7):1019–27. https://doi.org/10.1124/dmd.115.063107.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sager JE, Price LS, Isoherranen N. Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro. Drug Metab Dispos. 2016Oct;44(10):1709–19. https://doi.org/10.1124/dmd.116.072363.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kanu SS, Ojha A, Ramajayam R, Bhargava S, Bhavna,. An updated review on translabial mucosa: a significant area to design and deliver a drug. J Pharm Sci Res. 2020;12(11):1425–30.

CAS  Google Scholar 

Varshosaz J, Zaki MR, Minaiyan M, Banoozadeh J. Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design. Biomed Res Int. 2015;1: 571816. https://doi.org/10.1155/2015/571816.

Article  CAS  Google Scholar 

Swarnalatha N, Vidyavathi M, Rani JS. Design, characterization, and optimization of solid lipid nanoparticles of bupropion by using a 23 factorial design. Pharm Chem J. 2023;57:590–602. https://doi.org/10.1007/s11094-023-02924-y.

Article  CAS  Google Scholar 

Harini K, Alomar SY, Vajagathali M, Manohar Das S, Thirumalai A, Giri Goswami K, Giri Goswami A. Niosomal bupropion. Exploring therapeutic frontiers through behavioral profiling. Pharmaceuticals (Basel). 2024;17(3):366. https://doi.org/10.3390/ph17030366.

Article  PubMed  CAS  Google Scholar 

Muralidhar P, Bhargav E, Srinath B. Formulation and optimization of bupropion HCL microsponges by 23 factorial design. Int J Pharm Sci Res. 2017;8(3):1134–44. https://doi.org/10.13040/IJPSR.0975-8232.8(3).1134-44.

Article  Google Scholar 

Madhav NS, Yadav AP. A novel translabial platform utilizing bioexcipients from Litchi chinensis for the delivery of rosiglitazone maleate. Acta Pharmaceutica Sinica B. 2013;3(6):408–15. https://doi.org/10.1016/j.apsb.2013.10.004.

Article  Google Scholar 

Dede R, Kasabe A, Bhosale A, Gupta H, Bhalerao A, Chorage T. Formulation and Evaluation of Medicated Lipstick Using Pioglitazone. Int J Pharm Res Applic. 2021;6(5):693–6. https://doi.org/10.35629/7781-0605693696.

Article  Google Scholar 

Madhav N, Yadav A. Development and evaluation of novel repaglinide biostrips for translabial delivery. Int Res J Pharm. 2013;4(5):198–202. https://doi.org/10.7897/2230-8407.04540.

Article  CAS  Google Scholar 

Tiwari G, Tiwari R, Kaur A. Pharmaceutical Considerations of Translabial Formulations for Treatment of Parkinson’s Disease: A Concept of Drug Delivery for Unconscious Patients. Curr Drug Deliv. 2023;20(8):163–75. https://doi.org/10.2174/1567201819666220516161413.

Article  CAS  Google Scholar 

Shaker DS, Ishak RA, Ghoneim A, Elhuoni MA. Nanoemulsion: A review on mechanisms for the transdermal delivery of hydrophobic and hydrophilic drugs. Sci Pharm. 2019;87(3):17. https://doi.org/10.3390/scipharm87030017.

Article  CAS  Google Scholar 

Acharya SD, Tamane PK, Khante SN, Pokharkar VB. QbD-based optimization of curcumin nanoemulsion: DoE and cytotoxicity studies. Indian J Pharm Educ Res. 2020;54(2):329–36. https://doi.org/10.5530/ijper.54.2.38.

Article  CAS  Google Scholar 

Savale SK. Quality by design (QbD) approach used in development of pharmaceutical formulations. Asian J Biomater Res. 2017;3(6):11–24.

Google Scholar 

Cunha S, Costa CP, Moreira JN, Lobo JM, Silva AC. Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review. Nanomedicine. 2020Aug;1(28): 102206. https://doi.org/10.1016/j.nano.2020.102206.

Article  CAS  Google Scholar 

Waghule T, Dabholkar N, Gorantla S, Rapalli VK, Saha RN, Singhvi G. Quality by design (QbD) in the formulation and optimization of liquid crystalline nanoparticles (LCNPs): A risk-based industrial approach. Biomed Pharmacother. 2021Sep;1(141): 111940. https://doi.org/10.1016/j.biopha.2021.111940.

Article  CAS  Google Scholar 

Zen N.I.M., Gani S.S.A., Shamsudin R., Masoumi H.R.F., The use of D-optimal mixture design in optimizing development of Okara tablet formulation as a dietary supplement. Sci World J. 2015:684319. https://doi.org/10.1155/2015/684319.

Benowitz NL. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol. 2009;49(1):57–71. https://doi.org/10.1146/annurev.pharmtox.48.113006.094742.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nagano T, Katsurada M, Yasuda Y, Kobayashi K, Nishimura Y. Current pharmacologic treatments for smoking cessation and new agents undergoing clinical trials. Ther Adv Respir Dis. 2019;13:1753466619875925. https://doi.org/10.1177/1753466619875925.

Article  PubMed  PubMed Central  Google Scholar 

Lou D, Chang X, Li W, Zhao Q, Wang Y, Zhou Z. Paraquat affects the homeostasis of the dopaminergic system in PC12 cells. Pestic Biochem Physiol. 2012;103(2):81–6. https://doi.org/10.1016/j.pestbp.2012.04.001.

Article  CAS  Google Scholar 

Namini MS, Beheshtizadeh N, Ebrahimi-Barough S, Ai J. Human endometrial stem cell-derived small extracellular vesicles enhance neurite outgrowth and peripheral nerve regeneration through activating the PI3K/AKT signaling pathway. J Transl Med. 2025;23(1):6. https://doi.org/10.1186/s12967-024-06048-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Meerloo JV, Kaspers GJL, Cloos J. Cell sensitivity assays: the MTT assay. Methods Mol Biol. 2011;731:237–45. https://doi.org/10.1007/978-1-61779-080-5_20.

Article  PubMed  CAS  Google Scholar 

Fotakis G, Timbrell JA. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT, and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett. 2006Jan 5;160(2):171–7. https://doi.org/10.1016/j.toxlet.2005.07.001.

Article  PubMed  CAS  Google Scholar 

Ahmad U, Akhtar J, Singh SP, Badruddeen, Ahmad FJ, Siddiqui S, Wahaj U. Silymarin Nanoemulsion against Human Hepatocellular Carcinoma: Development and Optimization. Artif Cells Nanomed Biotechnol. 2018;46(2):231–41. https://doi.org/10.1080/21691401.2017.1324465.

Article  PubMed  CAS  Google Scholar 

Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, Talegaonkar S. Nanoemulsion components screening and selection: a technical note. AAPS Pharm SciTech. 2009;10(1):69–76. https://doi.org/10.1208/s12249-008-9178-x.

Article  CAS  Google Scholar 

Dhawan S, Nanda S. Implementation of the Quality by Design (QbD) concept for the development of emulsion-based nano-tailored gel for improved anti-photoaging potential of silymarin. J Drug Deliv Sci Technol. 2023Mar;1(81): 104201. https://doi.org/10.1016/j.jddst.2023.104201.

Article  CAS  Google Scholar 

Akhtar J, Siddiqui HH, Fareed S, Khalid BM, Aqil M. Nanoemulsion: for improved oral delivery of repaglinide. Drug Deliv. 2016;23(6):2026–34. https://doi.org/10.3109/10717544.2015.1077290.

Article  PubMed  CAS  Google Scholar 

ICH, International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, Pharmaceutical Development Q8 (R2), ICH Harmon. Tripart. Guidel, 2009. https://www.ema.europa.eu/en/ich-q8-r2-pharmaceutical-development-scientific-guideline

Thakur K, Mahajan A, Sharma G, Singh B, Raza K, Chhibber S, Katare OP. Implementation of the Quality by Design (QbD) approach in the development of silver sulfadiazine-loaded egg oil organogel: an improved dermatokinetic profile and therapeutic efficacy in burn wounds. Int J Pharm. 2020;576: 118977. https://doi.org/10.1016/j.ijpharm.2019.118977.

Article  PubMed  CAS  Google Scholar 

Shakeel F, Ramadan W. Transdermal delivery of anticancer drug caffeine from water-in-oil nanoemulsions. Colloids Surf B Biointerfaces. 2010;75(1):356–62. https://doi.org/10.1016/j.colsurfb.2009.09.010.