Thiocolchicoside Niosomal Gel: Design-Driven Optimization for Superior Skin Permeation

Gervasi M, Sisti D, Benelli P, Fernández-Peña E, Calcabrini C, Rocchi MBL, et al. The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness. Med (Baltim). 2017;96:e7659.

CAS  Google Scholar 

Reuter S, Gupta SC, Phromnoi K, Aggarwal BB. Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through Inhibition of inflammatory pathways: a new use for an old drug. Br J Pharmacol. 2012;165:2127–39.

PubMed  PubMed Central  CAS  Google Scholar 

Kumar S, Rani S, Siwach R, Verma P. To compare the efficacy and safety of fixed dose combination of thiocolchicoside and aceclofenac versus chlorzoxazone, aceclofenac and Paracetamol in patients with acute lower backache associated with muscle spasm. Int J Appl Basic Med Res. 2014;4:101.

PubMed  PubMed Central  Google Scholar 

Artusi M, Santi P, Colombo P, Junginger H. Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies. Int J Pharm. 2003;250:203–13.

PubMed  CAS  Google Scholar 

Khan BA, Naz F, Alqahtani A, Khalid Khan M. A nanocomposite competent to overcome solubility and permeation issues of capsaicin and thiocolchicoside simultaneously in gout management: fabrication of nanocubosomes. Saudi Pharm J. 2024;32:102050.

PubMed  PubMed Central  CAS  Google Scholar 

Kumar D, Ali J, Baboota S. Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies. Drug Deliv. 2016;23:591–600.

PubMed  CAS  Google Scholar 

El-Ridy MS, Yehia SA, Mohsen AM, El-Awdan SA, Darwish AB. Formulation of Niosomal gel for enhanced transdermal lornoxicam delivery: In-Vitro and In-Vivo evaluation. Curr Drug Deliv. 2018;15:122–33.

PubMed  CAS  Google Scholar 

Akbari J, Saeedi M, Morteza-Semnani K, Hashemi SMH, Babaei A, Eghbali M, et al. Innovative topical Niosomal gel formulation containing diclofenac sodium (niofenac). J Drug Target. 2022;30:108–17.

PubMed  Google Scholar 

Aguzzi C, Rossi S, Bagnasco M, Lanata L, Sandri G, Bona F, et al. Penetration and distribution of thiocolchicoside through human skin: comparison between a commercial foam (Miotens®) and a drug solution. AAPS PharmSciTech. 2008;9:1185–90.

PubMed  PubMed Central  CAS  Google Scholar 

Moammeri A, Chegeni MM, Sahrayi H, Ghafelehbashi R, Memarzadeh F, Mansouri A, et al. Current advances in niosomes applications for drug delivery and cancer treatment. Mater Today Bio. 2023;23:100837.

PubMed  PubMed Central  CAS  Google Scholar 

Manconi M, Sinico C, Valenti D, Lai F, Fadda AM. Niosomes as carriers for tretinoin. Int J Pharm. 2006;311:11–9.

PubMed  CAS  Google Scholar 

Abdelkader H, Alani AWG, Alany RG. Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations. Drug Deliv. 2014;21:87–100.

PubMed  CAS  Google Scholar 

Chen S, Hanning S, Falconer J, Locke M, Wen J. Recent advances in non-ionic surfactant vesicles (niosomes): fabrication, characterization, pharmaceutical and cosmetic applications. Eur J Pharm Biopharm. 2019;144:18–39.

PubMed  Google Scholar 

Baillie AJ, Florence AT, Hume LR, Muirhead GT, Rogerson A. The Preparation and properties of niosomes—non-ionic surfactant vesicles. J Pharm Pharmacol. 2011;37:863–8.

Google Scholar 

Azmin MN, Florence AT, Handjani-Vila RM, Stuart JFB, Vanlerberghe G, Whittaker JS. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J Pharm Pharmacol. 2011;37:237–42.

Google Scholar 

Kumbhar D, Wavikar P, Vavia P. Niosomal gel of lornoxicam for topical delivery: in vitro assessment and pharmacodynamic activity. AAPS PharmSciTech. 2013;14:1072–82.

PubMed  PubMed Central  CAS  Google Scholar 

Mali N, Darandale S, Vavia P. Niosomes as a vesicular carrier for topical administration of minoxidil: formulation and in vitro assessment. Drug Deliv Transl Res. 2013;3:587–92.

PubMed  CAS  Google Scholar 

Shevalkar G, Borse L. Self-microemulsifying drug delivery system (SMEDDS) for oral delivery of zafirlukast: design, formulation, and Pharmacokinetic evaluation. J Drug Deliv Sci Technol. 2024;101:106298.

CAS  Google Scholar 

Alsaidan OA, Zafar A, Al-Ruwaili RH, Yasir M, Alzarea SI, Alsaidan AA, et al. Niosomes gel of apigenin to improve the topical delivery: development, optimization, ex vivo permeation, antioxidant study, and in vivo evaluation. Artif Cells Nanomed Biotechnol. 2023;51:604–17.

PubMed  CAS  Google Scholar 

Shevalkar G, Pawar M, Vavia P. Nanostructured lipid carriers (NLCs) of lumefantrine with enhanced permeation. J Pharm Innov. 2022;17:1221–34.

Google Scholar 

Shevalkar G, Vavia P. Solidified nanostructured lipid carrier (S-NLC) for enhancing the oral bioavailability of Ezetimibe. J Drug Deliv Sci Technol. 2019;53:101211.

CAS  Google Scholar 

Chatur VM, Dhole SN, Kulkarni NS, Rudrapal M. Development and characterization of antifungal Niosomal gel of luliconazole: in vitro and ex vivo approaches. Chem Phys Impact. 2025;10:100801.

Google Scholar 

Wavikar P, Vavia P. Nanolipidgel for enhanced skin deposition and improved antifungal activity. AAPS PharmSciTech. 2013;14:222–33.

PubMed  CAS  Google Scholar 

Goyal G, Garg T, Malik B, Chauhan G, Rath G, Goyal AK. Development and characterization of Niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv. 2015;22:1027–42.

PubMed  CAS  Google Scholar 

Hegdekar NY, Priya S, Shetty SS, Jyothi D. Formulation and evaluation of Niosomal gel loaded with Asparagus racemosus extract for Anti-inflammatory activity. Indian J Pharm Educ Res. 2023;57:s63–74.

CAS  Google Scholar 

Pant A. Draize test. Dict Toxicol. 2024;314:5.

Google Scholar 

Shah A, Boldhane S, Pawar A, Bothiraja C. Advanced development of a non-ionic surfactant and cholesterol material based Niosomal gel formulation for the topical delivery of anti-acne drugs. Mater Adv. 2020;1:1763–74.

CAS  Google Scholar 

Mohanty D, Rani MJ, Haque MA, Bakshi V, Jahangir MA, Imam SS, et al. Preparation and evaluation of transdermal Naproxen niosomes: formulation optimization to preclinical anti-inflammatory assessment on murine model. J Liposome Res. 2020;30:377–87.

PubMed  CAS  Google Scholar 

Mohamed MI, Kassem MA, Khalil RM, Younis MM, Darwish AB, Salama A, et al. Enhancement of the Anti-inflammatory efficacy of betamethasone valerate via Niosomal encapsulation. Biointerface Res Appl Chem. 2021;11:14640–60.

CAS  Google Scholar 

Qumbar M, Ameeduzzafar, Imam SS, Ali J, Ahmad J, Ali A. Formulation and optimization of lacidipine loaded Niosomal gel for transdermal delivery: In-vitro characterization and in-vivo activity. Biomed Pharmacother. 2017;93:255–66.

PubMed  CAS  Google Scholar 

Mawazi SM, Ge Y, Widodo RT. Niosome Preparation techniques and Structure—An illustrated review. Pharmaceutics. 2025;17.

Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta Pharm Sin B. 2011;1:208–19.

Google Scholar 

Khoee S, Yaghoobian M. Niosomes: a novel approach in modern drug delivery systems. Nanostructures drug deliv. Elsevier Inc.; 2017.

Opatha SAT, Titapiwatanakun V, Chutoprapat R, Transfersomes. A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics. 2020;12:1–23.

Google Scholar 

Ghasemiyeh P, Mohammadi-Samani S. Potential of nanoparticles as permeation enhancers and targeted delivery options for skin: advantages and disadvantages. Drug Des Devel Ther. 2020;14:3271–89.

PubMed  PubMed Central  CAS  Google Scholar 

Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech. 2011;12:62–76.

PubMed  CAS  Google Scholar 

Rostamkalaei SS, Akbari J, Saeedi M, Morteza-Semnani K, Nokhodchi A. Topical gel of Metformin solid lipid nanoparticles: A hopeful promise as a dermal delivery system. Colloids Surf B Biointerfaces. 2019;175:150–7.

PubMed  CAS  Google Scholar 

Kiran T, Butt MS, Rafique S, Shabbir N, Khan DH, Yousaf Y et al. Green synthesis of Niosomal dual drug delivery systems for synergistic anticancer therapy. Colloids Surf Physicochem Eng Asp. 2025;136883.

Zolghadri S, Asad AG, Farzi F, Ghajarzadeh F, Habibi Z, Rahban M, et al. Span 60/cholesterol Niosomal formulation as a suitable vehicle for Gallic acid delivery with potent in vitro antibacterial, antimelanoma, and Anti-Tyrosinase activity. Pharmaceuticals. 2023;16:1680.

PubMed  PubMed Central  CAS  Google Scholar 

Jain N, Verma A, Jain N. Formulation and investigation of pilocarpine hydrochloride Niosomal gels for the treatment of glaucoma: intraocular pressure measurement in white albino rabbits. Drug Deliv. 2020;27:888–99.

PubMed  PubMed Central  CAS  Google Scholar 

Bhardwaj P, Tripathi P, Gupta R, Pandey S. Niosomes: A review on Niosomal research in the last decade. J Drug Deliv Sci Technol. 2020;56:101581.

CAS  Google Scholar 

Giuli MV, Hanieh PN, Forte J, Fabiano MG, Mancusi A, Natiello B, et al. pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer. Int J Pharm. 2024;649:123672.

PubMed  CAS  Google Scholar 

Annepogu H, Ahad HA, Nayakanti D. Determining the best poloxamer carrier for thiocolchicoside solid dispersions. Turkish J Pharm Sci. 2020;17:372–80.

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