Effectiveness and Tolerability of Trimetazidine 80 mg Once Daily in Patients with Chronic Coronary Syndrome in Brazil: The V-GOOD Observational Study

Ambrosio G, Collins P, Dechend R, Lopez-Sendon J, Manolis AJ, Camm AJ. StaBle Angina: PeRceptIon of NeeDs, Quality of Life and ManaGemEnt of Patients (BRIDGE Study)—a multinational European physician survey. Angiology. 2019;70(5):397–406.

Article  PubMed  Google Scholar 

Beltrame JF, Weekes AJ, Morgan C, Tavella R, Spertus JA. The prevalence of weekly angina among patients with chronic stable angina in primary care practices: the Coronary Artery Disease in General Practice (CADENCE) study. Arch Intern Med. 2009;169(16):1491–9.

Article  PubMed  Google Scholar 

Geovanini GR, Gowdak LHW, Pereira AC, Danzi-Soares NJ, Dourado LOC, Poppi NT, et al. OSA and depression are common and independently associated with refractory angina in patients with coronary artery disease. Chest. 2014;146(1):73–80.

Article  CAS  PubMed  Google Scholar 

Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023;148(9):e9–119.

Article  PubMed  Google Scholar 

Crea F, Bairey Merz CN, Beltrame JF, Berry C, Camici PG, Kaski JC, et al. Mechanisms and diagnostic evaluation of persistent or recurrent angina following percutaneous coronary revascularization. Eur Heart J. 2019;40(29):2455–62.

Article  PubMed  Google Scholar 

Al-Lamee R, Thompson D, Dehbi HM, Sen S, Tang K, Davies J, et al. Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. Lancet. 2018;391(10115):31–40.

Article  PubMed  Google Scholar 

Boden WE, Kaski JC, Al-Lamee R, Weintraub WS. What constitutes an appropriate empirical trial of antianginal therapy in patients with stable angina before referral for revascularisation? Lancet. 2022;399(10325):691–4.

Article  PubMed  Google Scholar 

Marzilli M, Vinereanu D, Lopaschuk G, Chen Y, Dalal JJ, Danchin N, et al. Trimetazidine in cardiovascular medicine. Int J Cardiol. 2019;15(293):39–44.

Article  Google Scholar 

Lopatin YM, Rosano GM, Fragasso G, Lopaschuk GD, Seferovic PM, Gowdak LH, et al. Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure. Int J Cardiol. 2016;15(203):909–15.

Article  Google Scholar 

Peng S, Zhao M, Wan J, Fang Q, Fang D, Li K. The efficacy of trimetazidine on stable angina pectoris: a meta-analysis of randomized clinical trials. Int J Cardiol. 2014;177(3):780–5.

Article  PubMed  Google Scholar 

Chazov EI, Lepakchin VK, Zharova EA, Fitilev SB, Levin AM, Rumiantzeva EG, et al. Trimetazidine in angina combination therapy—the TACT study: trimetazidine versus conventional treatment in patients with stable angina pectoris in a randomized, placebo-controlled, multicenter study. Am J Ther. 2005;12(1):35–42.

Szwed H, Sadowski Z, Elikowski W, Koronkiewicz A, Mamcarz A, Orszulak W, et al. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Eur Heart J. 2001;22(24):2267–74.

Article  CAS  PubMed  Google Scholar 

Detry JM, Sellier P, Pennaforte S, Cokkinos D, Dargie H, Mathes P. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Br J Clin Pharmacol. 1994;37(3):279–88.

Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, et al. 2024 ESC guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415–537.

Article  CAS  PubMed  Google Scholar 

Cesar LA, Ferreira JF, Armaganijan D, Gowdak LH, Mansur AP, Bodanese LC, et al. Guideline for stable coronary artery disease. Arq Bras Cardiol. 2014;103(2 Suppl 2):1–56.

CAS  PubMed  Google Scholar 

Sorbets E, Fox KM, Elbez Y, Danchin N, Dorian P, Ferrari R, et al. Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry. Eur Heart J. 2020;41(3):347–56.

Article  PubMed  Google Scholar 

Frishman WH. Importance of medication adherence in cardiovascular disease and the value of once-daily treatment regimens. Cardiol Rev. 2007;15(5):257–63.

Pozdnyakov YM, On Behalf of the Study Investigators. Clinical acceptability of trimetazidine modified-release 80 mg once daily versus trimetazidine modified-release 35 mg twice daily in stable angina pectoris. Cardiol Ther. 2018;7(1):61–70.

Glezer MG, Vygodin VA, Investigators ODA. Anti-anginal effectiveness and tolerability of trimetazidine modified release 80 mg once daily in stable angina patients in real-world practice. Adv Ther. 2018;35(9):1368–77.

Lopatin Y, Petrova P, Investigators MV. Effectiveness and tolerability of trimetazidine 80 mg once daily in patients with stable angina uncontrolled with bisoprolol-based therapy: the Modus Vivendi observational study. Cardiol Ther. 2022;11(1):93–111.

de Oliveira GMM, Brant LCC, Polanczyk CA, Malta DC, Biolo A, Nascimento BR, et al. Cardiovascular statistics—Brazil 2021 [in Portuguese]. Arq Bras Cardiol. 2022;118(1):115–373.

Article  PubMed  PubMed Central  Google Scholar 

Suarez-Kurtz G, Pena SD, Struchiner CJ, Hutz MH. Pharmacogenomic diversity among Brazilians: influence of ancestry, self-reported color, and geographical origin. Front Pharmacol. 2012;3:191.

Article  PubMed  PubMed Central  Google Scholar 

Girerd X, Radauceanu A, Achard JM, Fourcade J, Tournier B, Brillet G, et al. Evaluation of patient compliance among hypertensive patients treated by specialists [in French]. Arch Mal Coeur Vaiss. 2001;94(8):839–42.

CAS  PubMed  Google Scholar 

Muntner P, Shimbo D, Carey RM, Charleston JB, Gaillard T, Misra S, et al. Measurement of blood pressure in humans: a scientific statement from the American Heart Association. Hypertension. 2019;73(5):e35–66.

Article  CAS  PubMed  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–9.

Article  Google Scholar 

Ajabnoor A, Mukhtar A. Effect of trimetazidine on the functional capacity of ischemic heart disease patients not suitable for revascularization: meta-analysis of randomized controlled trials. PLoS ONE. 2022;17(2): e0263932.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danchin N, Marzilli M, Parkhomenko A, Ribeiro JP. Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analysis. Cardiology. 2011;120(2):59–72.

Article  CAS  PubMed  Google Scholar 

Mesnier J, Ducrocq G, Danchin N, Ferrari R, Ford I, Tardif JC, et al. International observational analysis of evolution and outcomes of chronic stable angina: the multinational CLARIFY study. Circulation. 2021;144(7):512–23.

Article  PubMed  PubMed Central  Google Scholar 

Hansen B, Holtzman JN, Juszczynski C, Khan N, Kaur G, Varma B, et al. Ischemia with No Obstructive Arteries (INOCA): a review of the prevalence, diagnosis and management. Curr Probl Cardiol. 2023;48(1): 101420.

Article  PubMed  Google Scholar 

Boden WE, Marzilli M, Crea F, Mancini GBJ, Weintraub WS, Taqueti VR, et al. Evolving management paradigm for stable ischemic heart disease patients: JACC Review Topic of the Week. J Am Coll Cardiol. 2023;81(5):505–14.

Article  PubMed  PubMed Central  Google Scholar 

Marzilli M, Merz CN, Boden WE, Bonow RO, Capozza PG, Chilian WM, et al. Obstructive coronary atherosclerosis and ischemic heart disease: an elusive link! J Am Coll Cardiol. 2012;60(11):951–6.

Article  PubMed  Google Scholar 

Ferrari R, Camici PG, Crea F, Danchin N, Fox K, Maggioni AP, et al. Expert consensus document: a “diamond” approach to personalized treatment of angina. Nat Rev Cardiol. 2018;15(2):120–32.

Article  PubMed  Google Scholar 

Laboratórios Servier do Brasil Ltda. Summary of product characteristics—Vastarel. 2023. https://servier.com.br/wp-content/uploads/2023/11/23.11.07_Vastarel-caps-LP_Bula-do-profissional.pdf. Cited 1 July 2024.

Weeda ER, Coleman CI, McHorney CA, Crivera C, Schein JR, Sobieraj DM. Impact of once- or twice-daily dosing frequency on adherence to chronic cardiovascular disease medications: a meta-regression analysis. Int J Cardiol. 2016;1(216):104–9.

Article  Google Scholar 

Fragasso G, Piatti Md PM, Monti L, Palloshi A, Setola E, Puccetti P, et al. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am Heart J. 2003;146(5):E18.

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif