Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982;218:585–7. https://doi.org/10.1126/science.6812220.

Article  CAS  PubMed  Google Scholar 

Rivier J, Spiess J, Thorner M, Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature. 1982;300:276–8. https://doi.org/10.1038/300276a0.

Article  CAS  PubMed  Google Scholar 

Bloch B, Gaillard RC, Brazeau P, Lin HD, Ling N. Topographical and ontogenetic study of the neurons producing growth hormone-releasing factor in human hypothalamus. Regul Pept. 1984;8:21–31. https://doi.org/10.1016/0167-0115(84)90025-9.

Article  CAS  PubMed  Google Scholar 

Frohman LA, Kineman RD. Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis. TEM. 2002;13:299–303. https://doi.org/10.1016/S1043-2760(02)00613-6.

Article  CAS  PubMed  Google Scholar 

Müller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev. 1999;79:511–607. https://doi.org/10.1152/physrev.1999.79.2.511.

Article  PubMed  Google Scholar 

Mayo KE, Godfrey PA, Suhr ST, Kulik DJ, Rahal JO. Growth hormone-releasing hormone: synthesis and signaling. Recent Prog Horm Res. 1995;50:35–73. https://doi.org/10.1016/b978-0-12-571150-0.50007-x.

Article  CAS  PubMed  Google Scholar 

Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010;9:4110–6. https://doi.org/10.4161/cc.9.20.13787.

Article  CAS  PubMed  Google Scholar 

Murray PG, Higham CE, Clayton PE. 60 years of neuroendocrinology: The hypothalamo-GH axis: the past 60 years. J Endocrinol. 2015;226:T123-140. https://doi.org/10.1530/JOE-15-0120.

Article  CAS  PubMed  Google Scholar 

Kiaris H, Chatzistamou I, Schally AV, Halmos G, Varga JL, Koutselini H, Kalofoutis A. Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor. Proc Natl Acad Sci USA. 2003;100:9512–7. https://doi.org/10.1073/pnas.1533185100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christodoulou C, Schally AV, Chatzistamou I, Kondi-Pafiti A, Lamnissou K, Kouloheri S, Kalofoutis A, Kiaris H. Expression of growth hormone-releasing hormone (GHRH) and splice variant of GHRH receptors in normal mouse tissues. Regul Pept. 2006;136:105–8. https://doi.org/10.1016/j.regpep.2006.05.001.

Article  CAS  PubMed  Google Scholar 

Kiaris H, Schally AV, Kalofoutis A. Extrapituitary effects of the growth hormone-releasing hormone. Vitam Horm. 2005;70:1–24. https://doi.org/10.1016/S0083-6729(05)70001-7.

Article  CAS  PubMed  Google Scholar 

Matsubara S, Sato M, Mizobuchi M, Niimi M, Takahara J. Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues. Endocrinology. 1995;136:4147–50. https://doi.org/10.1210/en.136.9.4147.

Article  CAS  PubMed  Google Scholar 

Berry SA, Srivastava CH, Rubin LR, Phipps WR, Pescovitz OH. Growth hormone-releasing hormone-like messenger ribonucleic acid and immunoreactive peptide are present in human testis and placenta. J Clin Endocrinol Metab. 1992;75:281–4. https://doi.org/10.1210/jcem.75.1.1619020.

Article  CAS  PubMed  Google Scholar 

Granata R. Peripheral activities of growth hormone-releasing hormone. J Endocrinol Invest. 2016;39:721–7. https://doi.org/10.1007/s40618-016-0440-x.

Article  CAS  PubMed  Google Scholar 

Szabo Z, Juhasz E, Schally AV, Dezso B, Huga S, Hernadi Z, Halmos G, Kiss C. Expression of growth hormone-releasing hormone and its receptor splice variants in primary human endometrial carcinomas: novel therapeutic approaches. Molecules. 2022;27:2671. https://doi.org/10.3390/molecules27092671.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shohreh R, Pardo CA, Guaraldi F, Schally AV, Salvatori R. GH, But Not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis. Endocrinology. 2011;152:3803–10. https://doi.org/10.1210/en.2011-1317.

Article  CAS  PubMed  Google Scholar 

Sun LY, Spong A, Swindell WR, Fang Y, Hill C, Huber JA, Boehm JD, Westbrook R, Salvatori R, Bartke A. Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. eLife. 2013;2:e01098. https://doi.org/10.7554/eLife.01098

Leone S, Shohreh R, Manippa F, Recinella L, Ferrante C, Orlando G, Salvatori R, Vacca M, Brunetti L. Behavioural phenotyping of male growth hormone-releasing hormone (GHRH) knockout mice. Growth Horm IGF Res. 2014;24:192–7. https://doi.org/10.1016/j.ghir.2014.06.004.

Article  CAS  PubMed  Google Scholar 

Leone S, Chiavaroli A, Shohreh R, Ferrante C, Ricciuti A, Manippa F, Recinella L, Di Nisio C, Orlando G, Salvatori R, Vacca M, Brunetti L. Increased locomotor and thermogenic activity in mice with targeted ablation of the GHRH gene. Growth Horm IGF Res. 2015;25:80–4. https://doi.org/10.1016/j.ghir.2014.12.007.

Article  CAS  PubMed  Google Scholar 

Leone S, Chiavaroli A, Recinella L, Di Valerio V, Veschi S, Gasparo I, Bitto A, Ferrante C, Orlando G, Salvatori R, Brunetti L. Growth hormone-releasing hormone (GHRH) deficiency promotes inflammation-associated carcinogenesis. Pharmacol Res. 2020;152:104614. https://doi.org/10.1016/j.phrs.2019.104614.

Article  CAS  PubMed  Google Scholar 

Leone S, Chiavaroli A, Recinella L, Orlando G, Ferrante C, Marconi GD, Gasparo I, Bitto A, Salvatori R, Brunetti L. Increased pain and inflammatory sensitivity in growth hormone-releasing hormone (GHRH) knockout mice. Prostag Oth Lipid Mediat. 2019;144:106362. https://doi.org/10.1016/j.prostaglandins.2019.106362.

Article  CAS  Google Scholar 

Recinella L, Chiavaroli A, Di Valerio V, Veschi S, Orlando G, Ferrante C, Gesmundo I, Granata R, Cai R, Sha W, Schally AV, Lattanzio R, Brunetti L, Leone S. Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice. Sci Rep. 2021;11:2530. https://doi.org/10.1038/s41598-021-81778-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Recinella L, Libero ML, Veschi S, Piro A, Marconi GD, Diomede F, Chiavaroli A, Orlando G, Ferrante C, Florio R, Lamolinara A, Cai R, Sha W, Schally AV, Salvatori R, Brunetti L, Leone S. Effects of GHRH Deficiency and GHRH antagonism on emotional disorders in mice. Cells. 2023;12:2615. https://doi.org/10.3390/cells12222615.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Granata R, Trovato L, Gallo MP, Destefanis S, Settanni F, Scarlatti F, Brero A, Ramella R, Volante M, Isgaard J, Levi R, Papotti M, Alloatti G, Ghigo E. Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia–reperfusion injury in rat heart. Cardiovasc Res. 2009;83:303–12. https://doi.org/10.1093/cvr/cvp090.

Article  CAS  PubMed  Google Scholar 

Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M. Actions and potential therapeutic applications of growth hormone-releasing hormone agonists. Endocrinology. 2019;160:1600–12. https://doi.org/10.1210/en.2019-00111.

Article  CAS  PubMed  Google Scholar 

Jaszberenyi M, Rick FG, Szalontay L, Block NL, Zarandi M, Cai R-Z, Schally AV. Beneficial effects of novel antagonists of GHRH in different models of Alzheimer’s disease. Aging (Albany NY). 2012;4:755–67. https://doi.org/10.18632/aging.100504.

Article  CAS  PubMed  Google Scholar 

Leone S, Recinella L, Chiavaroli A, Ferrante C, Orlando G, Vacca M, Salvatori R, Brunetti L. Behavioural phenotyping, learning and memory in young and aged growth hormone-releasing hormone-knockout mice. Endocr Connect. 2018;7:924–31. https://doi.org/10.1530/EC-18-0165.

Article  CAS  PubMed  PubMed Central