Pituitary adenomas: biology, nomenclature and clinical classification

Ho KKY, Fleseriu M, Wass J, van der Lely A, Barkan A, Giustina A, et al. A tale of pituitary adenomas: to NET or not to NET : Pituitary Society position statement. Pituitary. 2019;22(6):569–73.

Article  PubMed  Google Scholar 

Melmed S, Kaiser UB, Lopes MB, Bertherat J, Syro LV, Raverot G, et al. Clinical biology of the pituitary adenoma. Endocr Rev. 2022;43(6):1003–37.

Article  PubMed  PubMed Central  Google Scholar 

Asa SL, Mete O, Perry A, Osamura RY. Overview of the 2022 WHO Classification of Pituitary Tumors. Endocr Pathol. 2022;33(1):6–26.

Article  CAS  PubMed  Google Scholar 

Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, et al. Pituitary neoplasm nomenclature workshop: does adenoma stand the test of time? J Endocr Soc. 2021;5(3):bvaa205.

Ho KKY, Kaiser UB, Chanson P, Gadelha M, Wass J, Nieman L, et al. Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification. Nat Rev Endocrinol. 2023;19(11):671–8.

Article  PubMed  Google Scholar 

Ho KKY, Fleseriu M, Wass J, Katznelson L, Raverot G, Little AS, et al. A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis. Lancet Diabetes Endocrinol. 2024;12(3):209–14.

Article  PubMed  Google Scholar 

Molitch ME. Nonfunctioning pituitary tumors. Handb Clin Neurol. 2014;124:167–84.

Article  PubMed  Google Scholar 

Gruppetta M, Mercieca C, Vassallo J. Prevalence and incidence of pituitary adenomas: a population based study in Malta. Pituitary. 2013;16(4):545–53.

Article  PubMed  Google Scholar 

Chong BW, Kucharczyk W, Singer W, George S. Pituitary gland MR: a comparative study of healthy volunteers and patients with microadenomas. AJNR Am J Neuroradiol. 1994;15(4):675–9.

CAS  PubMed  PubMed Central  Google Scholar 

Raappana A, Koivukangas J, Ebeling T, Pirila T. Incidence of pituitary adenomas in Northern Finland in 1992–2007. J Clin Endocrinol Metab. 2010;95(9):4268–75.

Article  CAS  PubMed  Google Scholar 

Tjornstrand A, Gunnarsson K, Evert M, Holmberg E, Ragnarsson O, Rosen T, et al. The incidence rate of pituitary adenomas in western Sweden for the period 2001–2011. Eur J Endocrinol. 2014;171(4):519–26.

Article  PubMed  Google Scholar 

Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA, Beckers A. High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege Belgium. J Clin Endocrinol Metab. 2006;91(12):4769–75.

Article  CAS  PubMed  Google Scholar 

Fontana E, Gaillard R. Epidemiology of pituitary adenoma: results of the first Swiss study. Rev Med Suisse. 2009;5(223):2172–4.

CAS  PubMed  Google Scholar 

Fernandez A, Karavitaki N, Wass JA. Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK). Clin Endocrinol (Oxf). 2010;72(3):377–82.

Article  PubMed  Google Scholar 

Agustsson TT, Baldvinsdottir T, Jonasson JG, Olafsdottir E, Steinthorsdottir V, Sigurdsson G, et al. The epidemiology of pituitary adenomas in Iceland, 1955–2012: a nationwide population-based study. Eur J Endocrinol. 2015;173(5):655–64.

Article  CAS  PubMed  Google Scholar 

Ho KKY, Fleseriu M, Wass J, van der Lely A, Barkan A, Giustina A, et al. The tale in evolution: clarity, consistency and consultation, not contradiction and confusion. Pituitary. 2020;23(4):476–7.

Article  PubMed  Google Scholar 

Dekkers OM, Karavitaki N, Pereira AM. The epidemiology of aggressive pituitary tumors (and its challenges). Rev Endocr Metab Disord. 2020;21(2):209–12.

Article  PubMed  PubMed Central  Google Scholar 

Saeger W, Ludecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S. Pathohistological classification of pituitary tumors: 10 years of experience with the German pituitary tumor registry. Eur J Endocrinol. 2007;156(2):203–16.

Article  CAS  PubMed  Google Scholar 

Trouillas J, Roy P, Sturm N, Dantony E, Cortet-Rudelli C, Viennet G, et al. A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol. 2013;126(1):123–35.

Article  PubMed  Google Scholar 

Alshaikh OM, Asa SL, Mete O, Ezzat S. An institutional experience of tumor progression to pituitary carcinoma in a 15-Year cohort of 1055 consecutive pituitary neuroendocrine tumors. Endocr Pathol. 2019;30(2):118–27.

Article  PubMed  Google Scholar 

Pernicone PJ, Scheithauer BW, Sebo TJ, Kovacs KT, Horvath E, Young WF Jr, et al. Pituitary carcinoma: a clinicopathologic study of 15 cases. Cancer. 1997;79(4):804–12.

Article  CAS  PubMed  Google Scholar 

Taal BG, Visser O. Epidemiology of neuroendocrine tumours. Neuroendocrinology. 2004;80(Suppl 1):3–7.

Article  CAS  PubMed  Google Scholar 

Asa SL, Casar-Borota O, Chanson P, Delgrange E, Earls P, Ezzat S, et al. From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an international pituitary pathology club proposal. Endocr Relat Cancer. 2017;24(4):C5–8.

Article  CAS  PubMed  Google Scholar 

Jutel A. Classification, disease, and diagnosis. Perspect Biol Med. 2011;54(2):189–205.

Article  PubMed  Google Scholar 

Doust JA, Bell KJL, Glasziou PP. Potential consequences of changing disease classifications. JAMA. 2020;323(10):921–2.

Doust J, Vandvik PO, Qaseem A, Mustafa RA, Horvath AR, Frances A, et al. Guidance for modifying the definition of diseases: a checklist. JAMA Intern Med. 2017;177(7):1020–5.

Article  PubMed  Google Scholar 

Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3(10):1335–42.

Article  PubMed  PubMed Central  Google Scholar 

Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, et al. Overview of the 2022 WHO classification of neuroendocrine neoplasms. Endocr Pathol. 2022;33(1):115–54.

Article  CAS  PubMed  Google Scholar 

Dixon PR, Tomlinson G, Pasternak JD, Mete O, Bell CM, Sawka AM, et al. The role of disease label in patient perceptions and treatment decisions in the setting of low-risk malignant neoplasms. JAMA Oncol. 2019;5(6):817–23.

Article  PubMed  PubMed Central  Google Scholar 

Chadha NK, Repanos C. Patients’ understanding of words used to describe lumps: a cross-sectional study. J Laryngol Otol. 2006;120(2):125–8.

Article  PubMed  Google Scholar 

Van den Bruel A. The triumph of medicine: how overdiagnosis is turning healthy people into patients. Fam Pract. 2015;32(2):127–8.

Article  PubMed  Google Scholar 

Glasziou PP, Bell KJ, Barratt AL. Estimating the magnitude of cancer overdiagnosis in Australia. Med J Aust. 2020;213(4):189-e1.

Article  PubMed  Google Scholar 

Meagher T. From benign to malignant: the arrival of pituitary neuroendocrine tumors (PitNETs). J Insur Med. 2024;50:154–6.

Article  Google Scholar 

Brat D, Gill A, Wesseling P et al. Tumours of the sellar region. Central Nervous System Tumours WHO Classification of Tumours 6. 5 ed: International Agency for Research on Cancer; 2021.

Ho KKY, Melmed S. Letter to the Editor from Ho and Melmed: clinical practice and nomenclature of pituitary neoplasms: common sense must prevail. J Clin Endocrinol Metab. 2024.

Stewart PM. Clinical practice and nomenclature of pituitary neoplasms: common sense must prevail. J Clin Endocrinol Metab. 2024;109(5):e1408–9.

Article  PubMed  Google Scholar 

Medsger TA Jr, Bombardieri S, Czirjak L, Scorza R, Della Rossa A, Bencivelli W. Assessment of disease severity and prognosis. Clin Exp Rheumatol. 2003;21(3 Suppl 29):S42-6.

PubMed  Google Scholar 

Dekkers OM, Biermasz NR, Pereira AM, Romijn JA, Vandenbroucke JP. Mortality in acromegaly: a metaanalysis. J Clin Endocrinol Me

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